Dichotomy of cellular inhibition by small-molecule inhibitors revealed by single-cell analysis

Many drugs are small molecule inhibitors of cell signalling. Through single cell analysis and mathematical modelling here the authors show that cell-to-cell variability diversifies inhibition response into digital and analogue, and that the two translate into distinct long-term functional responses.

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Autores principales:	Robert M. Vogel, Amir Erez, Grégoire Altan-Bonnet
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ee31dd9b59f14c6fb131538cdce61e18
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spelling	oai:doaj.org-article:ee31dd9b59f14c6fb131538cdce61e182021-12-02T15:34:10ZDichotomy of cellular inhibition by small-molecule inhibitors revealed by single-cell analysis10.1038/ncomms124282041-1723https://doaj.org/article/ee31dd9b59f14c6fb131538cdce61e182016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12428https://doaj.org/toc/2041-1723Many drugs are small molecule inhibitors of cell signalling. Through single cell analysis and mathematical modelling here the authors show that cell-to-cell variability diversifies inhibition response into digital and analogue, and that the two translate into distinct long-term functional responses.Robert M. VogelAmir ErezGrégoire Altan-BonnetNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Robert M. Vogel Amir Erez Grégoire Altan-Bonnet Dichotomy of cellular inhibition by small-molecule inhibitors revealed by single-cell analysis
description	Many drugs are small molecule inhibitors of cell signalling. Through single cell analysis and mathematical modelling here the authors show that cell-to-cell variability diversifies inhibition response into digital and analogue, and that the two translate into distinct long-term functional responses.
format	article
author	Robert M. Vogel Amir Erez Grégoire Altan-Bonnet
author_facet	Robert M. Vogel Amir Erez Grégoire Altan-Bonnet
author_sort	Robert M. Vogel
title	Dichotomy of cellular inhibition by small-molecule inhibitors revealed by single-cell analysis
title_short	Dichotomy of cellular inhibition by small-molecule inhibitors revealed by single-cell analysis
title_full	Dichotomy of cellular inhibition by small-molecule inhibitors revealed by single-cell analysis
title_fullStr	Dichotomy of cellular inhibition by small-molecule inhibitors revealed by single-cell analysis
title_full_unstemmed	Dichotomy of cellular inhibition by small-molecule inhibitors revealed by single-cell analysis
title_sort	dichotomy of cellular inhibition by small-molecule inhibitors revealed by single-cell analysis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/ee31dd9b59f14c6fb131538cdce61e18
work_keys_str_mv	AT robertmvogel dichotomyofcellularinhibitionbysmallmoleculeinhibitorsrevealedbysinglecellanalysis AT amirerez dichotomyofcellularinhibitionbysmallmoleculeinhibitorsrevealedbysinglecellanalysis AT gregoirealtanbonnet dichotomyofcellularinhibitionbysmallmoleculeinhibitorsrevealedbysinglecellanalysis
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Dichotomy of cellular inhibition by small-molecule inhibitors revealed by single-cell analysis

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