Single-cell analyses of Crohn’s disease tissues reveal intestinal intraepithelial T cells heterogeneity and altered subset distributions

Crohn’s disease results from transmural inflammation in the gut, but analyses of local immune populations are still lacking. Here, the authors show, by combining multiple single-cell approaches, that intraepithelial and lamina propria T cells are heterogenous, show unique phenotypes, and exhibit alt...

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Autores principales:	Natalia Jaeger, Ramya Gamini, Marina Cella, Jorge L. Schettini, Mattia Bugatti, Shanrong Zhao, Charles V. Rosadini, Ekaterina Esaulova, Blanda Di Luccia, Baylee Kinnett, William Vermi, Maxim N. Artyomov, Thomas A. Wynn, Ramnik J. Xavier, Scott A. Jelinsky, Marco Colonna
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ee35def1314c47afa68c82658ec56e94
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spelling	oai:doaj.org-article:ee35def1314c47afa68c82658ec56e942021-12-02T17:04:30ZSingle-cell analyses of Crohn’s disease tissues reveal intestinal intraepithelial T cells heterogeneity and altered subset distributions10.1038/s41467-021-22164-62041-1723https://doaj.org/article/ee35def1314c47afa68c82658ec56e942021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22164-6https://doaj.org/toc/2041-1723Crohn’s disease results from transmural inflammation in the gut, but analyses of local immune populations are still lacking. Here, the authors show, by combining multiple single-cell approaches, that intraepithelial and lamina propria T cells are heterogenous, show unique phenotypes, and exhibit altered subsets upon inflammation.Natalia JaegerRamya GaminiMarina CellaJorge L. SchettiniMattia BugattiShanrong ZhaoCharles V. RosadiniEkaterina EsaulovaBlanda Di LucciaBaylee KinnettWilliam VermiMaxim N. ArtyomovThomas A. WynnRamnik J. XavierScott A. JelinskyMarco ColonnaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Natalia Jaeger Ramya Gamini Marina Cella Jorge L. Schettini Mattia Bugatti Shanrong Zhao Charles V. Rosadini Ekaterina Esaulova Blanda Di Luccia Baylee Kinnett William Vermi Maxim N. Artyomov Thomas A. Wynn Ramnik J. Xavier Scott A. Jelinsky Marco Colonna Single-cell analyses of Crohn’s disease tissues reveal intestinal intraepithelial T cells heterogeneity and altered subset distributions
description	Crohn’s disease results from transmural inflammation in the gut, but analyses of local immune populations are still lacking. Here, the authors show, by combining multiple single-cell approaches, that intraepithelial and lamina propria T cells are heterogenous, show unique phenotypes, and exhibit altered subsets upon inflammation.
format	article
author	Natalia Jaeger Ramya Gamini Marina Cella Jorge L. Schettini Mattia Bugatti Shanrong Zhao Charles V. Rosadini Ekaterina Esaulova Blanda Di Luccia Baylee Kinnett William Vermi Maxim N. Artyomov Thomas A. Wynn Ramnik J. Xavier Scott A. Jelinsky Marco Colonna
author_facet	Natalia Jaeger Ramya Gamini Marina Cella Jorge L. Schettini Mattia Bugatti Shanrong Zhao Charles V. Rosadini Ekaterina Esaulova Blanda Di Luccia Baylee Kinnett William Vermi Maxim N. Artyomov Thomas A. Wynn Ramnik J. Xavier Scott A. Jelinsky Marco Colonna
author_sort	Natalia Jaeger
title	Single-cell analyses of Crohn’s disease tissues reveal intestinal intraepithelial T cells heterogeneity and altered subset distributions
title_short	Single-cell analyses of Crohn’s disease tissues reveal intestinal intraepithelial T cells heterogeneity and altered subset distributions
title_full	Single-cell analyses of Crohn’s disease tissues reveal intestinal intraepithelial T cells heterogeneity and altered subset distributions
title_fullStr	Single-cell analyses of Crohn’s disease tissues reveal intestinal intraepithelial T cells heterogeneity and altered subset distributions
title_full_unstemmed	Single-cell analyses of Crohn’s disease tissues reveal intestinal intraepithelial T cells heterogeneity and altered subset distributions
title_sort	single-cell analyses of crohn’s disease tissues reveal intestinal intraepithelial t cells heterogeneity and altered subset distributions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ee35def1314c47afa68c82658ec56e94
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Single-cell analyses of Crohn’s disease tissues reveal intestinal intraepithelial T cells heterogeneity and altered subset distributions

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