Pulsatile inputs achieve tunable attenuation of gene expression variability and graded multi-gene regulation

Natural transcription factors are often regulated in a pulsatile fashion unlike many synthetic systems. Here the authors show that dynamic pulsatile signals reduce cell-to-cell gene expression variability in an optogenetic construct.

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Detalles Bibliográficos
Autores principales:	Dirk Benzinger, Mustafa Khammash
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ee3b2292e31c4f589980cf5e69d19370
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spelling	oai:doaj.org-article:ee3b2292e31c4f589980cf5e69d193702021-12-02T14:41:15ZPulsatile inputs achieve tunable attenuation of gene expression variability and graded multi-gene regulation10.1038/s41467-018-05882-22041-1723https://doaj.org/article/ee3b2292e31c4f589980cf5e69d193702018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05882-2https://doaj.org/toc/2041-1723Natural transcription factors are often regulated in a pulsatile fashion unlike many synthetic systems. Here the authors show that dynamic pulsatile signals reduce cell-to-cell gene expression variability in an optogenetic construct.Dirk BenzingerMustafa KhammashNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dirk Benzinger Mustafa Khammash Pulsatile inputs achieve tunable attenuation of gene expression variability and graded multi-gene regulation
description	Natural transcription factors are often regulated in a pulsatile fashion unlike many synthetic systems. Here the authors show that dynamic pulsatile signals reduce cell-to-cell gene expression variability in an optogenetic construct.
format	article
author	Dirk Benzinger Mustafa Khammash
author_facet	Dirk Benzinger Mustafa Khammash
author_sort	Dirk Benzinger
title	Pulsatile inputs achieve tunable attenuation of gene expression variability and graded multi-gene regulation
title_short	Pulsatile inputs achieve tunable attenuation of gene expression variability and graded multi-gene regulation
title_full	Pulsatile inputs achieve tunable attenuation of gene expression variability and graded multi-gene regulation
title_fullStr	Pulsatile inputs achieve tunable attenuation of gene expression variability and graded multi-gene regulation
title_full_unstemmed	Pulsatile inputs achieve tunable attenuation of gene expression variability and graded multi-gene regulation
title_sort	pulsatile inputs achieve tunable attenuation of gene expression variability and graded multi-gene regulation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ee3b2292e31c4f589980cf5e69d19370
work_keys_str_mv	AT dirkbenzinger pulsatileinputsachievetunableattenuationofgeneexpressionvariabilityandgradedmultigeneregulation AT mustafakhammash pulsatileinputsachievetunableattenuationofgeneexpressionvariabilityandgradedmultigeneregulation
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Pulsatile inputs achieve tunable attenuation of gene expression variability and graded multi-gene regulation

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