A large chromosomal inversion shapes gene expression in seaweed flies (Coelopa frigida)

Abstract Inversions often underlie complex adaptive traits, but the genic targets inside them are largely unknown. Gene expression profiling provides a powerful way to link inversions with their phenotypic consequences. We examined the effects of the Cf‐Inv(1) inversion in the seaweed fly Coelopa fr...

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Autores principales:	Emma L. Berdan, Claire Mérot, Henrik Pavia, Kerstin Johannesson, Maren Wellenreuther, Roger K. Butlin
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	Chromosomal evolution gene expression genetic architecture population genomics Evolution QH359-425
Acceso en línea:	https://doaj.org/article/ee3c7b6f8793465c97d3bc3251c26c6e
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spelling	oai:doaj.org-article:ee3c7b6f8793465c97d3bc3251c26c6e2021-12-05T14:03:53ZA large chromosomal inversion shapes gene expression in seaweed flies (Coelopa frigida)2056-374410.1002/evl3.260https://doaj.org/article/ee3c7b6f8793465c97d3bc3251c26c6e2021-12-01T00:00:00Zhttps://doi.org/10.1002/evl3.260https://doaj.org/toc/2056-3744Abstract Inversions often underlie complex adaptive traits, but the genic targets inside them are largely unknown. Gene expression profiling provides a powerful way to link inversions with their phenotypic consequences. We examined the effects of the Cf‐Inv(1) inversion in the seaweed fly Coelopa frigida on gene expression variation across sexes and life stages. Our analyses revealed that Cf‐Inv(1) shapes global expression patterns, most likely via linked variation, but the extent of this effect is variable, with much stronger effects in adults than larvae. Furthermore, within adults, both common as well as sex‐specific patterns were found. The vast majority of these differentially expressed genes mapped to Cf‐Inv(1). However, genes that were differentially expressed in a single context (i.e., in males, females, or larvae) were more likely to be located outside of Cf‐Inv(1). By combining our findings with genomic scans for environmentally associated SNPs, we were able to pinpoint candidate variants in the inversion that may underlie mechanistic pathways that determine phenotypes. Together the results of this study, combined with previous findings, support the notion that the polymorphic Cf‐Inv(1) inversion in this species is a major factor shaping both coding and regulatory variation resulting in highly complex adaptive effects.Emma L. BerdanClaire MérotHenrik PaviaKerstin JohannessonMaren WellenreutherRoger K. ButlinWileyarticleChromosomal evolutiongene expressiongenetic architecturepopulation genomicsEvolutionQH359-425ENEvolution Letters, Vol 5, Iss 6, Pp 607-624 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chromosomal evolution gene expression genetic architecture population genomics Evolution QH359-425
spellingShingle	Chromosomal evolution gene expression genetic architecture population genomics Evolution QH359-425 Emma L. Berdan Claire Mérot Henrik Pavia Kerstin Johannesson Maren Wellenreuther Roger K. Butlin A large chromosomal inversion shapes gene expression in seaweed flies (Coelopa frigida)
description	Abstract Inversions often underlie complex adaptive traits, but the genic targets inside them are largely unknown. Gene expression profiling provides a powerful way to link inversions with their phenotypic consequences. We examined the effects of the Cf‐Inv(1) inversion in the seaweed fly Coelopa frigida on gene expression variation across sexes and life stages. Our analyses revealed that Cf‐Inv(1) shapes global expression patterns, most likely via linked variation, but the extent of this effect is variable, with much stronger effects in adults than larvae. Furthermore, within adults, both common as well as sex‐specific patterns were found. The vast majority of these differentially expressed genes mapped to Cf‐Inv(1). However, genes that were differentially expressed in a single context (i.e., in males, females, or larvae) were more likely to be located outside of Cf‐Inv(1). By combining our findings with genomic scans for environmentally associated SNPs, we were able to pinpoint candidate variants in the inversion that may underlie mechanistic pathways that determine phenotypes. Together the results of this study, combined with previous findings, support the notion that the polymorphic Cf‐Inv(1) inversion in this species is a major factor shaping both coding and regulatory variation resulting in highly complex adaptive effects.
format	article
author	Emma L. Berdan Claire Mérot Henrik Pavia Kerstin Johannesson Maren Wellenreuther Roger K. Butlin
author_facet	Emma L. Berdan Claire Mérot Henrik Pavia Kerstin Johannesson Maren Wellenreuther Roger K. Butlin
author_sort	Emma L. Berdan
title	A large chromosomal inversion shapes gene expression in seaweed flies (Coelopa frigida)
title_short	A large chromosomal inversion shapes gene expression in seaweed flies (Coelopa frigida)
title_full	A large chromosomal inversion shapes gene expression in seaweed flies (Coelopa frigida)
title_fullStr	A large chromosomal inversion shapes gene expression in seaweed flies (Coelopa frigida)
title_full_unstemmed	A large chromosomal inversion shapes gene expression in seaweed flies (Coelopa frigida)
title_sort	large chromosomal inversion shapes gene expression in seaweed flies (coelopa frigida)
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/ee3c7b6f8793465c97d3bc3251c26c6e
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A large chromosomal inversion shapes gene expression in seaweed flies (Coelopa frigida)

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