The fluid membrane determines mechanics of erythrocyte extracellular vesicles and is softened in hereditary spherocytosis

Red blood cell disorders are often accompanied by increased release of extracellular vesicles (EVs), but their structural and mechanical properties are not fully understood. Here, the authors show that red blood cell EVs show liposome-like mechanical features and are softened in blood disorder patie...

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Autores principales:	Daan Vorselen, Susan M. van Dommelen, Raya Sorkin, Melissa C. Piontek, Jürgen Schiller, Sander T. Döpp, Sander A. A. Kooijmans, Brigitte A. van Oirschot, Birgitta A. Versluijs, Marc B. Bierings, Richard van Wijk, Raymond M. Schiffelers, Gijs J. L. Wuite, Wouter H. Roos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ee3d649d089e45a59a0d4b1fccb687f2
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spelling	oai:doaj.org-article:ee3d649d089e45a59a0d4b1fccb687f22021-12-02T14:39:25ZThe fluid membrane determines mechanics of erythrocyte extracellular vesicles and is softened in hereditary spherocytosis10.1038/s41467-018-07445-x2041-1723https://doaj.org/article/ee3d649d089e45a59a0d4b1fccb687f22018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07445-xhttps://doaj.org/toc/2041-1723Red blood cell disorders are often accompanied by increased release of extracellular vesicles (EVs), but their structural and mechanical properties are not fully understood. Here, the authors show that red blood cell EVs show liposome-like mechanical features and are softened in blood disorder patients.Daan VorselenSusan M. van DommelenRaya SorkinMelissa C. PiontekJürgen SchillerSander T. DöppSander A. A. KooijmansBrigitte A. van OirschotBirgitta A. VersluijsMarc B. BieringsRichard van WijkRaymond M. SchiffelersGijs J. L. WuiteWouter H. RoosNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daan Vorselen Susan M. van Dommelen Raya Sorkin Melissa C. Piontek Jürgen Schiller Sander T. Döpp Sander A. A. Kooijmans Brigitte A. van Oirschot Birgitta A. Versluijs Marc B. Bierings Richard van Wijk Raymond M. Schiffelers Gijs J. L. Wuite Wouter H. Roos The fluid membrane determines mechanics of erythrocyte extracellular vesicles and is softened in hereditary spherocytosis
description	Red blood cell disorders are often accompanied by increased release of extracellular vesicles (EVs), but their structural and mechanical properties are not fully understood. Here, the authors show that red blood cell EVs show liposome-like mechanical features and are softened in blood disorder patients.
format	article
author	Daan Vorselen Susan M. van Dommelen Raya Sorkin Melissa C. Piontek Jürgen Schiller Sander T. Döpp Sander A. A. Kooijmans Brigitte A. van Oirschot Birgitta A. Versluijs Marc B. Bierings Richard van Wijk Raymond M. Schiffelers Gijs J. L. Wuite Wouter H. Roos
author_facet	Daan Vorselen Susan M. van Dommelen Raya Sorkin Melissa C. Piontek Jürgen Schiller Sander T. Döpp Sander A. A. Kooijmans Brigitte A. van Oirschot Birgitta A. Versluijs Marc B. Bierings Richard van Wijk Raymond M. Schiffelers Gijs J. L. Wuite Wouter H. Roos
author_sort	Daan Vorselen
title	The fluid membrane determines mechanics of erythrocyte extracellular vesicles and is softened in hereditary spherocytosis
title_short	The fluid membrane determines mechanics of erythrocyte extracellular vesicles and is softened in hereditary spherocytosis
title_full	The fluid membrane determines mechanics of erythrocyte extracellular vesicles and is softened in hereditary spherocytosis
title_fullStr	The fluid membrane determines mechanics of erythrocyte extracellular vesicles and is softened in hereditary spherocytosis
title_full_unstemmed	The fluid membrane determines mechanics of erythrocyte extracellular vesicles and is softened in hereditary spherocytosis
title_sort	fluid membrane determines mechanics of erythrocyte extracellular vesicles and is softened in hereditary spherocytosis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ee3d649d089e45a59a0d4b1fccb687f2
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The fluid membrane determines mechanics of erythrocyte extracellular vesicles and is softened in hereditary spherocytosis

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