Munc18-1 is crucial to overcome the inhibition of synaptic vesicle fusion by αSNAP

Munc18-1 and Munc13-1 are key for the exquisite regulation of neurotransmitter release. Here biophysical experiments show how αSNAP inhibits liposome fusion mediated by the neuronal SNAREs and how Munc18-1 overcomes this inhibition, ensuring that release depends on Munc18-1 and Munc13-1.

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Detalles Bibliográficos
Autores principales:	Karolina P. Stepien, Eric A. Prinslow, Josep Rizo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ee3eb8e8c9514aa6aec1f6119b3e36cb
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spelling	oai:doaj.org-article:ee3eb8e8c9514aa6aec1f6119b3e36cb2021-12-02T15:35:15ZMunc18-1 is crucial to overcome the inhibition of synaptic vesicle fusion by αSNAP10.1038/s41467-019-12188-42041-1723https://doaj.org/article/ee3eb8e8c9514aa6aec1f6119b3e36cb2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12188-4https://doaj.org/toc/2041-1723Munc18-1 and Munc13-1 are key for the exquisite regulation of neurotransmitter release. Here biophysical experiments show how αSNAP inhibits liposome fusion mediated by the neuronal SNAREs and how Munc18-1 overcomes this inhibition, ensuring that release depends on Munc18-1 and Munc13-1.Karolina P. StepienEric A. PrinslowJosep RizoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Karolina P. Stepien Eric A. Prinslow Josep Rizo Munc18-1 is crucial to overcome the inhibition of synaptic vesicle fusion by αSNAP
description	Munc18-1 and Munc13-1 are key for the exquisite regulation of neurotransmitter release. Here biophysical experiments show how αSNAP inhibits liposome fusion mediated by the neuronal SNAREs and how Munc18-1 overcomes this inhibition, ensuring that release depends on Munc18-1 and Munc13-1.
format	article
author	Karolina P. Stepien Eric A. Prinslow Josep Rizo
author_facet	Karolina P. Stepien Eric A. Prinslow Josep Rizo
author_sort	Karolina P. Stepien
title	Munc18-1 is crucial to overcome the inhibition of synaptic vesicle fusion by αSNAP
title_short	Munc18-1 is crucial to overcome the inhibition of synaptic vesicle fusion by αSNAP
title_full	Munc18-1 is crucial to overcome the inhibition of synaptic vesicle fusion by αSNAP
title_fullStr	Munc18-1 is crucial to overcome the inhibition of synaptic vesicle fusion by αSNAP
title_full_unstemmed	Munc18-1 is crucial to overcome the inhibition of synaptic vesicle fusion by αSNAP
title_sort	munc18-1 is crucial to overcome the inhibition of synaptic vesicle fusion by αsnap
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ee3eb8e8c9514aa6aec1f6119b3e36cb
work_keys_str_mv	AT karolinapstepien munc181iscrucialtoovercometheinhibitionofsynapticvesiclefusionbyasnap AT ericaprinslow munc181iscrucialtoovercometheinhibitionofsynapticvesiclefusionbyasnap AT joseprizo munc181iscrucialtoovercometheinhibitionofsynapticvesiclefusionbyasnap
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Munc18-1 is crucial to overcome the inhibition of synaptic vesicle fusion by αSNAP

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