PHENOTYPIC CHARACTERIZATION AND INTRACELLULAR CYTOKINES OF MEMORY T-CELLS IN MULTIPLE SCLEROSIS PATIENTS AFTER T-CELL VACCINATION
Multiple sclerosis (RS) patients were treated with a vaccine consisted of autological mielin-reactive T-cells. Effector memory CD8+ CD45RO+CD62L- T-cells as well as central memory CD4+ CD45RO+CD62L+ and CD8+ CD45RO+CD62L+ T-cells were significantly increased in MS patients as compared with levels in...
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| Autores principales: | , , , , |
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| Formato: | article |
| Lenguaje: | RU |
| Publicado: |
Scientific Сentre for Family Health and Human Reproduction Problems
2012
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/ee411714e31946c3b9cab6b8a0bde114 |
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| Sumario: | Multiple sclerosis (RS) patients were treated with a vaccine consisted of autological mielin-reactive T-cells. Effector memory CD8+ CD45RO+CD62L- T-cells as well as central memory CD4+ CD45RO+CD62L+ and CD8+ CD45RO+CD62L+ T-cells were significantly increased in MS patients as compared with levels in healthy individuals. T-cells vaccination had no effect on the T-cells memory subpopulation composition. However, vaccine-treated RS patients had significant (by 2 fold) reduction of relative quantity of CD4+IFNγ+IL-4— and CD8+IFNγ+IL-4— memory T-cells, as well as suppression by 6 fold of CD4+ memory cells number, which produce both kinds of cytokines. |
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