PHENOTYPIC CHARACTERIZATION AND INTRACELLULAR CYTOKINES OF MEMORY T-CELLS IN MULTIPLE SCLEROSIS PATIENTS AFTER T-CELL VACCINATION

Multiple sclerosis (RS) patients were treated with a vaccine consisted of autological mielin-reactive T-cells. Effector memory CD8+ CD45RO+CD62L- T-cells as well as central memory CD4+ CD45RO+CD62L+ and CD8+ CD45RO+CD62L+ T-cells were significantly increased in MS patients as compared with levels in...

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Autores principales:	I. P. Ivanova, I. V. Savkin, G. V. Seledtsova, A. A. Shishkov, V. I. Seledtsov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2012
Materias:	memory t-cells multiple sclerosis Science Q
Acceso en línea:	https://doaj.org/article/ee411714e31946c3b9cab6b8a0bde114
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id	oai:doaj.org-article:ee411714e31946c3b9cab6b8a0bde114
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spelling	oai:doaj.org-article:ee411714e31946c3b9cab6b8a0bde1142021-11-23T06:14:19ZPHENOTYPIC CHARACTERIZATION AND INTRACELLULAR CYTOKINES OF MEMORY T-CELLS IN MULTIPLE SCLEROSIS PATIENTS AFTER T-CELL VACCINATION2541-94202587-9596https://doaj.org/article/ee411714e31946c3b9cab6b8a0bde1142012-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/890https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Multiple sclerosis (RS) patients were treated with a vaccine consisted of autological mielin-reactive T-cells. Effector memory CD8+ CD45RO+CD62L- T-cells as well as central memory CD4+ CD45RO+CD62L+ and CD8+ CD45RO+CD62L+ T-cells were significantly increased in MS patients as compared with levels in healthy individuals. T-cells vaccination had no effect on the T-cells memory subpopulation composition. However, vaccine-treated RS patients had significant (by 2 fold) reduction of relative quantity of CD4+IFNγ+IL-4— and CD8+IFNγ+IL-4— memory T-cells, as well as suppression by 6 fold of CD4+ memory cells number, which produce both kinds of cytokines.I. P. IvanovaI. V. SavkinG. V. SeledtsovaA. A. ShishkovV. I. SeledtsovScientific Сentre for Family Health and Human Reproduction Problemsarticlememory t-cellsmultiple sclerosisScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3(2), Pp 79-82 (2012)
institution	DOAJ
collection	DOAJ
language	RU
topic	memory t-cells multiple sclerosis Science Q
spellingShingle	memory t-cells multiple sclerosis Science Q I. P. Ivanova I. V. Savkin G. V. Seledtsova A. A. Shishkov V. I. Seledtsov PHENOTYPIC CHARACTERIZATION AND INTRACELLULAR CYTOKINES OF MEMORY T-CELLS IN MULTIPLE SCLEROSIS PATIENTS AFTER T-CELL VACCINATION
description	Multiple sclerosis (RS) patients were treated with a vaccine consisted of autological mielin-reactive T-cells. Effector memory CD8+ CD45RO+CD62L- T-cells as well as central memory CD4+ CD45RO+CD62L+ and CD8+ CD45RO+CD62L+ T-cells were significantly increased in MS patients as compared with levels in healthy individuals. T-cells vaccination had no effect on the T-cells memory subpopulation composition. However, vaccine-treated RS patients had significant (by 2 fold) reduction of relative quantity of CD4+IFNγ+IL-4— and CD8+IFNγ+IL-4— memory T-cells, as well as suppression by 6 fold of CD4+ memory cells number, which produce both kinds of cytokines.
format	article
author	I. P. Ivanova I. V. Savkin G. V. Seledtsova A. A. Shishkov V. I. Seledtsov
author_facet	I. P. Ivanova I. V. Savkin G. V. Seledtsova A. A. Shishkov V. I. Seledtsov
author_sort	I. P. Ivanova
title	PHENOTYPIC CHARACTERIZATION AND INTRACELLULAR CYTOKINES OF MEMORY T-CELLS IN MULTIPLE SCLEROSIS PATIENTS AFTER T-CELL VACCINATION
title_short	PHENOTYPIC CHARACTERIZATION AND INTRACELLULAR CYTOKINES OF MEMORY T-CELLS IN MULTIPLE SCLEROSIS PATIENTS AFTER T-CELL VACCINATION
title_full	PHENOTYPIC CHARACTERIZATION AND INTRACELLULAR CYTOKINES OF MEMORY T-CELLS IN MULTIPLE SCLEROSIS PATIENTS AFTER T-CELL VACCINATION
title_fullStr	PHENOTYPIC CHARACTERIZATION AND INTRACELLULAR CYTOKINES OF MEMORY T-CELLS IN MULTIPLE SCLEROSIS PATIENTS AFTER T-CELL VACCINATION
title_full_unstemmed	PHENOTYPIC CHARACTERIZATION AND INTRACELLULAR CYTOKINES OF MEMORY T-CELLS IN MULTIPLE SCLEROSIS PATIENTS AFTER T-CELL VACCINATION
title_sort	phenotypic characterization and intracellular cytokines of memory t-cells in multiple sclerosis patients after t-cell vaccination
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2012
url	https://doaj.org/article/ee411714e31946c3b9cab6b8a0bde114
work_keys_str_mv	AT ipivanova phenotypiccharacterizationandintracellularcytokinesofmemorytcellsinmultiplesclerosispatientsaftertcellvaccination AT ivsavkin phenotypiccharacterizationandintracellularcytokinesofmemorytcellsinmultiplesclerosispatientsaftertcellvaccination AT gvseledtsova phenotypiccharacterizationandintracellularcytokinesofmemorytcellsinmultiplesclerosispatientsaftertcellvaccination AT aashishkov phenotypiccharacterizationandintracellularcytokinesofmemorytcellsinmultiplesclerosispatientsaftertcellvaccination AT viseledtsov phenotypiccharacterizationandintracellularcytokinesofmemorytcellsinmultiplesclerosispatientsaftertcellvaccination
_version_	1718417291009327104

PHENOTYPIC CHARACTERIZATION AND INTRACELLULAR CYTOKINES OF MEMORY T-CELLS IN MULTIPLE SCLEROSIS PATIENTS AFTER T-CELL VACCINATION

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