Potential Regenerative Capacity of physiological serum, L-arginine and IGF-1 on Skeletal Muscle

In post-mitotic tissues such as skeletal muscles, there are no significant cell replacements throughout life; the cells sustain local damage through its pool of specified stem cells. Muscle satellite cells are mononuclear cells that remain in a quiescent state till be activated; when they proliferat...

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Autor principal:	Naglaa Mohammed Alkalamawy
Formato:	article
Lenguaje:	EN
Publicado:	South Valley University 2018
Materias:	Myogenic stem cell IGF-1 Serum l-arginine Skeletal muscle regeneration Agriculture S Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/ee41611ea82c4334b051d2c8e87c8cf9
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spelling	oai:doaj.org-article:ee41611ea82c4334b051d2c8e87c8cf92021-12-02T00:44:46ZPotential Regenerative Capacity of physiological serum, L-arginine and IGF-1 on Skeletal Muscle2535-18262535-1877https://doaj.org/article/ee41611ea82c4334b051d2c8e87c8cf92018-07-01T00:00:00Zhttps://portal.svu.edu.eg/svu-src/index.php/ijvs/article/view/5https://doaj.org/toc/2535-1826https://doaj.org/toc/2535-1877In post-mitotic tissues such as skeletal muscles, there are no significant cell replacements throughout life; the cells sustain local damage through its pool of specified stem cells. Muscle satellite cells are mononuclear cells that remain in a quiescent state till be activated; when they proliferate and fuse with muscle fibers to donate myonuclei, a process necessary for post-embryonic growth, hypertrophy and tissue repair in this post-mitotic tissue. Modern trends in using (autologous) biological agents in the initiation of the regenerative process encourage us to evaluate the efficacy of some of these agents. In this study muscle damage was induced by cardiotoxin; followed by administration of biological agents; autologous physiological serum, L-arginine, and IGF-1 as a stimulating factor of myogenic satellite cells to initiate the myogenic regenerative process. Our study refers to variable degrees of efficacy in stimulation of myogenic stem cells differentiation and the outcome of the regenerative process. Although the physiological serum had marked ability to stimulate MSC high number of newly formed myotubules are split. L-arginine despite had delayed regenerating time, but more organization of newly formed myotubules was retained. IGF-1 had a rapid effect but associated with a considerable number of newly formed split myotubules. We could conclude that for perfect regenerative myogenic tissue not main just formation muscle fibers, but these fibers must be organized and functional. Healthy functional regenerative process need synchronization of several agents should be considered.Naglaa Mohammed AlkalamawySouth Valley UniversityarticleMyogenic stem cellIGF-1Seruml-arginineSkeletal muscle regenerationAgricultureSVeterinary medicineSF600-1100ENSVU-International Journal of Veterinary Sciences, Vol 1, Iss 1, Pp 90-101 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Myogenic stem cell IGF-1 Serum l-arginine Skeletal muscle regeneration Agriculture S Veterinary medicine SF600-1100
spellingShingle	Myogenic stem cell IGF-1 Serum l-arginine Skeletal muscle regeneration Agriculture S Veterinary medicine SF600-1100 Naglaa Mohammed Alkalamawy Potential Regenerative Capacity of physiological serum, L-arginine and IGF-1 on Skeletal Muscle
description	In post-mitotic tissues such as skeletal muscles, there are no significant cell replacements throughout life; the cells sustain local damage through its pool of specified stem cells. Muscle satellite cells are mononuclear cells that remain in a quiescent state till be activated; when they proliferate and fuse with muscle fibers to donate myonuclei, a process necessary for post-embryonic growth, hypertrophy and tissue repair in this post-mitotic tissue. Modern trends in using (autologous) biological agents in the initiation of the regenerative process encourage us to evaluate the efficacy of some of these agents. In this study muscle damage was induced by cardiotoxin; followed by administration of biological agents; autologous physiological serum, L-arginine, and IGF-1 as a stimulating factor of myogenic satellite cells to initiate the myogenic regenerative process. Our study refers to variable degrees of efficacy in stimulation of myogenic stem cells differentiation and the outcome of the regenerative process. Although the physiological serum had marked ability to stimulate MSC high number of newly formed myotubules are split. L-arginine despite had delayed regenerating time, but more organization of newly formed myotubules was retained. IGF-1 had a rapid effect but associated with a considerable number of newly formed split myotubules. We could conclude that for perfect regenerative myogenic tissue not main just formation muscle fibers, but these fibers must be organized and functional. Healthy functional regenerative process need synchronization of several agents should be considered.
format	article
author	Naglaa Mohammed Alkalamawy
author_facet	Naglaa Mohammed Alkalamawy
author_sort	Naglaa Mohammed Alkalamawy
title	Potential Regenerative Capacity of physiological serum, L-arginine and IGF-1 on Skeletal Muscle
title_short	Potential Regenerative Capacity of physiological serum, L-arginine and IGF-1 on Skeletal Muscle
title_full	Potential Regenerative Capacity of physiological serum, L-arginine and IGF-1 on Skeletal Muscle
title_fullStr	Potential Regenerative Capacity of physiological serum, L-arginine and IGF-1 on Skeletal Muscle
title_full_unstemmed	Potential Regenerative Capacity of physiological serum, L-arginine and IGF-1 on Skeletal Muscle
title_sort	potential regenerative capacity of physiological serum, l-arginine and igf-1 on skeletal muscle
publisher	South Valley University
publishDate	2018
url	https://doaj.org/article/ee41611ea82c4334b051d2c8e87c8cf9
work_keys_str_mv	AT naglaamohammedalkalamawy potentialregenerativecapacityofphysiologicalserumlarginineandigf1onskeletalmuscle
_version_	1718403531806867456

Potential Regenerative Capacity of physiological serum, L-arginine and IGF-1 on Skeletal Muscle

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