Necro-inflammatory activity grading in chronic viral hepatitis with three-dimensional multifrequency MR elastography

Abstract The purpose of this study was to assess the diagnostic value of multifrequency MR elastography for grading necro-inflammation in the liver. Fifty participants with chronic hepatitis B or C were recruited for this institutional review board-approved study. Their liver was examined with multi...

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Autores principales:	Philippe Garteiser, Gwenaël Pagé, Gaspard d’Assignies, Helena S. Leitao, Valérie Vilgrain, Ralph Sinkus, Bernard E. Van Beers
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ee4172fb9aaf4dd5ab6bb0f96bd82325
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spelling	oai:doaj.org-article:ee4172fb9aaf4dd5ab6bb0f96bd823252021-12-02T17:37:29ZNecro-inflammatory activity grading in chronic viral hepatitis with three-dimensional multifrequency MR elastography10.1038/s41598-021-98726-x2045-2322https://doaj.org/article/ee4172fb9aaf4dd5ab6bb0f96bd823252021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98726-xhttps://doaj.org/toc/2045-2322Abstract The purpose of this study was to assess the diagnostic value of multifrequency MR elastography for grading necro-inflammation in the liver. Fifty participants with chronic hepatitis B or C were recruited for this institutional review board-approved study. Their liver was examined with multifrequency MR elastography. The storage, shear and loss moduli, and the damping ratio were measured at 56 Hz. The multifrequency wave dispersion coefficient of the shear modulus was calculated. The measurements were compared to reference markers of necro-inflammation and fibrosis with Spearman correlations and multiple regression analysis. Diagnostic accuracy was assessed. At multiple regression analysis, necro-inflammation was the only determinant of the multifrequency dispersion coefficient, whereas fibrosis was the only determinant of the storage, loss and shear moduli. The multifrequency dispersion coefficient had the largest AUC for necro-inflammatory activity A ≥ 2 [0.84 (0.71–0.93) vs. storage modulus AUC: 0.65 (0.50–0.79), p = 0.03], whereas the storage modulus had the largest AUC for fibrosis F ≥ 2 [AUC (95% confidence intervals) 0.91 (0.79–0.98)] and cirrhosis F4 [0.97 (0.88–1.00)]. The measurement of the multifrequency dispersion coefficient at three-dimensional MR elastography has the potential to grade liver necro-inflammation in patients with chronic vial hepatitis.Philippe GarteiserGwenaël PagéGaspard d’AssigniesHelena S. LeitaoValérie VilgrainRalph SinkusBernard E. Van BeersNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Philippe Garteiser Gwenaël Pagé Gaspard d’Assignies Helena S. Leitao Valérie Vilgrain Ralph Sinkus Bernard E. Van Beers Necro-inflammatory activity grading in chronic viral hepatitis with three-dimensional multifrequency MR elastography
description	Abstract The purpose of this study was to assess the diagnostic value of multifrequency MR elastography for grading necro-inflammation in the liver. Fifty participants with chronic hepatitis B or C were recruited for this institutional review board-approved study. Their liver was examined with multifrequency MR elastography. The storage, shear and loss moduli, and the damping ratio were measured at 56 Hz. The multifrequency wave dispersion coefficient of the shear modulus was calculated. The measurements were compared to reference markers of necro-inflammation and fibrosis with Spearman correlations and multiple regression analysis. Diagnostic accuracy was assessed. At multiple regression analysis, necro-inflammation was the only determinant of the multifrequency dispersion coefficient, whereas fibrosis was the only determinant of the storage, loss and shear moduli. The multifrequency dispersion coefficient had the largest AUC for necro-inflammatory activity A ≥ 2 [0.84 (0.71–0.93) vs. storage modulus AUC: 0.65 (0.50–0.79), p = 0.03], whereas the storage modulus had the largest AUC for fibrosis F ≥ 2 [AUC (95% confidence intervals) 0.91 (0.79–0.98)] and cirrhosis F4 [0.97 (0.88–1.00)]. The measurement of the multifrequency dispersion coefficient at three-dimensional MR elastography has the potential to grade liver necro-inflammation in patients with chronic vial hepatitis.
format	article
author	Philippe Garteiser Gwenaël Pagé Gaspard d’Assignies Helena S. Leitao Valérie Vilgrain Ralph Sinkus Bernard E. Van Beers
author_facet	Philippe Garteiser Gwenaël Pagé Gaspard d’Assignies Helena S. Leitao Valérie Vilgrain Ralph Sinkus Bernard E. Van Beers
author_sort	Philippe Garteiser
title	Necro-inflammatory activity grading in chronic viral hepatitis with three-dimensional multifrequency MR elastography
title_short	Necro-inflammatory activity grading in chronic viral hepatitis with three-dimensional multifrequency MR elastography
title_full	Necro-inflammatory activity grading in chronic viral hepatitis with three-dimensional multifrequency MR elastography
title_fullStr	Necro-inflammatory activity grading in chronic viral hepatitis with three-dimensional multifrequency MR elastography
title_full_unstemmed	Necro-inflammatory activity grading in chronic viral hepatitis with three-dimensional multifrequency MR elastography
title_sort	necro-inflammatory activity grading in chronic viral hepatitis with three-dimensional multifrequency mr elastography
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ee4172fb9aaf4dd5ab6bb0f96bd82325
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Necro-inflammatory activity grading in chronic viral hepatitis with three-dimensional multifrequency MR elastography

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