Decreased angiogenesis as a possible pathomechanism in cervical degenerative myelopathy

Abstract Endogenous immune mediated reactions of inflammation and angiogenesis are components of the spinal cord injury in patients with degenerative cervical myelopathy (DCM). The aim of this study was to identify alteration of certain mediators participating in angiogenetic and inflammatory reacti...

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Autores principales:	Christian Blume, M. F. Geiger, M. Müller, H. Clusmann, V. Mainz, J. Kalder, L. O. Brandenburg, C. A. Mueller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ee452f99afee4510a26d9d4d08927029
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spelling	oai:doaj.org-article:ee452f99afee4510a26d9d4d089270292021-12-02T14:16:17ZDecreased angiogenesis as a possible pathomechanism in cervical degenerative myelopathy10.1038/s41598-021-81766-82045-2322https://doaj.org/article/ee452f99afee4510a26d9d4d089270292021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81766-8https://doaj.org/toc/2045-2322Abstract Endogenous immune mediated reactions of inflammation and angiogenesis are components of the spinal cord injury in patients with degenerative cervical myelopathy (DCM). The aim of this study was to identify alteration of certain mediators participating in angiogenetic and inflammatory reactions in patients with DCM. A consecutive series of 42 patients with DCM and indication for surgical decompression were enrolled for the study. 28 DCM patients were included, as CSF samples were taken preoperatively. We enrolled 42 patients requiring surgery for a thoracic abdominal aortic aneurysm (TAAA) as neurologically healthy controls. In 38 TAAA patients, CSF samples were taken prior to surgery and thus included. We evaluated the neurological status of patients and controls prior to surgery including NDI and mJOA. Protein-concentrations of factors with a crucial role in inflammation and angiogenesis were measured in CSF via ELISA testing (pg/ml): Angiopoietin 2, VEGF-A and C, RANTES, IL 1 beta and IL 8. Additionally, evaluated the status of the blood-spinal cord barrier (BSCB) by Reibers´diagnostic in all participants. Groups evidently differed in their neurological status (mJOA: DCM 10.1 ± 3.3, TAAA 17.3 ± 1.2, p < .001; NDI: DCM 47.4 ± 19.7, TAAA 5.3 ± 8.6, p < .001). There were no particular differences in age and gender distribution. However, we detected statistically significant differences in concentrations of mediators between the groups: Angiopoietin 2 (DCM 267.1.4 ± 81.9, TAAA 408.6 ± 177.1, p < .001) and VEGF C (DCM 152.2 ± 96.1, TAAA 222.4 ± 140.3, p = .04). DCM patients presented a mild to moderate BSCB disruption, controls had no signs of impairment. In patients with DCM, we measured decreased concentrations of angiogenic mediators. These results correspond to findings of immune mediated secondary harm in acute spinal cord injury. Reduced angiogenic activity could be a relevant part of the pathogenesis of DCM and secondary harm to the spinal cord.Christian BlumeM. F. GeigerM. MüllerH. ClusmannV. MainzJ. KalderL. O. BrandenburgC. A. MuellerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christian Blume M. F. Geiger M. Müller H. Clusmann V. Mainz J. Kalder L. O. Brandenburg C. A. Mueller Decreased angiogenesis as a possible pathomechanism in cervical degenerative myelopathy
description	Abstract Endogenous immune mediated reactions of inflammation and angiogenesis are components of the spinal cord injury in patients with degenerative cervical myelopathy (DCM). The aim of this study was to identify alteration of certain mediators participating in angiogenetic and inflammatory reactions in patients with DCM. A consecutive series of 42 patients with DCM and indication for surgical decompression were enrolled for the study. 28 DCM patients were included, as CSF samples were taken preoperatively. We enrolled 42 patients requiring surgery for a thoracic abdominal aortic aneurysm (TAAA) as neurologically healthy controls. In 38 TAAA patients, CSF samples were taken prior to surgery and thus included. We evaluated the neurological status of patients and controls prior to surgery including NDI and mJOA. Protein-concentrations of factors with a crucial role in inflammation and angiogenesis were measured in CSF via ELISA testing (pg/ml): Angiopoietin 2, VEGF-A and C, RANTES, IL 1 beta and IL 8. Additionally, evaluated the status of the blood-spinal cord barrier (BSCB) by Reibers´diagnostic in all participants. Groups evidently differed in their neurological status (mJOA: DCM 10.1 ± 3.3, TAAA 17.3 ± 1.2, p < .001; NDI: DCM 47.4 ± 19.7, TAAA 5.3 ± 8.6, p < .001). There were no particular differences in age and gender distribution. However, we detected statistically significant differences in concentrations of mediators between the groups: Angiopoietin 2 (DCM 267.1.4 ± 81.9, TAAA 408.6 ± 177.1, p < .001) and VEGF C (DCM 152.2 ± 96.1, TAAA 222.4 ± 140.3, p = .04). DCM patients presented a mild to moderate BSCB disruption, controls had no signs of impairment. In patients with DCM, we measured decreased concentrations of angiogenic mediators. These results correspond to findings of immune mediated secondary harm in acute spinal cord injury. Reduced angiogenic activity could be a relevant part of the pathogenesis of DCM and secondary harm to the spinal cord.
format	article
author	Christian Blume M. F. Geiger M. Müller H. Clusmann V. Mainz J. Kalder L. O. Brandenburg C. A. Mueller
author_facet	Christian Blume M. F. Geiger M. Müller H. Clusmann V. Mainz J. Kalder L. O. Brandenburg C. A. Mueller
author_sort	Christian Blume
title	Decreased angiogenesis as a possible pathomechanism in cervical degenerative myelopathy
title_short	Decreased angiogenesis as a possible pathomechanism in cervical degenerative myelopathy
title_full	Decreased angiogenesis as a possible pathomechanism in cervical degenerative myelopathy
title_fullStr	Decreased angiogenesis as a possible pathomechanism in cervical degenerative myelopathy
title_full_unstemmed	Decreased angiogenesis as a possible pathomechanism in cervical degenerative myelopathy
title_sort	decreased angiogenesis as a possible pathomechanism in cervical degenerative myelopathy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ee452f99afee4510a26d9d4d08927029
work_keys_str_mv	AT christianblume decreasedangiogenesisasapossiblepathomechanismincervicaldegenerativemyelopathy AT mfgeiger decreasedangiogenesisasapossiblepathomechanismincervicaldegenerativemyelopathy AT mmuller decreasedangiogenesisasapossiblepathomechanismincervicaldegenerativemyelopathy AT hclusmann decreasedangiogenesisasapossiblepathomechanismincervicaldegenerativemyelopathy AT vmainz decreasedangiogenesisasapossiblepathomechanismincervicaldegenerativemyelopathy AT jkalder decreasedangiogenesisasapossiblepathomechanismincervicaldegenerativemyelopathy AT lobrandenburg decreasedangiogenesisasapossiblepathomechanismincervicaldegenerativemyelopathy AT camueller decreasedangiogenesisasapossiblepathomechanismincervicaldegenerativemyelopathy
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Decreased angiogenesis as a possible pathomechanism in cervical degenerative myelopathy

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