Evaluation of ventricular systolic function by speckle tracking technique in patients with biliary atresia before and after liver transplantation

Abstract To evaluate the ventricular function of patients with biliary atresia (BA) before and after liver transplantation using two-dimensional speckle tracking. Observational, analytical study with healthy control group, volunteers. We recruited patients from 0 to 18 years old who were candidates...

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Autores principales:	Márcio Miranda Brito, Helena Thie Miyatani, Paulo Renato de Alencar Pereira, Ana Cristina Aoun Tannuri, Uenis Tannuri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ee472ce14d9f44e28062b2ebf4b15a89
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spelling	oai:doaj.org-article:ee472ce14d9f44e28062b2ebf4b15a892021-12-02T14:58:46ZEvaluation of ventricular systolic function by speckle tracking technique in patients with biliary atresia before and after liver transplantation10.1038/s41598-021-97096-82045-2322https://doaj.org/article/ee472ce14d9f44e28062b2ebf4b15a892021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97096-8https://doaj.org/toc/2045-2322Abstract To evaluate the ventricular function of patients with biliary atresia (BA) before and after liver transplantation using two-dimensional speckle tracking. Observational, analytical study with healthy control group, volunteers. We recruited patients from 0 to 18 years old who were candidates for liver transplantation and patients after six months of liver transplantation performed for BA from January 1997 to August 2015 at Children’s Institute of São Paulo University Medical School. The patients were submitted to a complete conventional echocardiographic study. After that, the images were captured for global longitudinal strain (GLS). A blood sample was collected for brain natriuretic peptide (BNP) level. Ejection fraction obtained by Simpson’s method was significantly higher in the hepatic pre-transplantation group (p < 0.001), as well as left atrial size (p < 0.001) and left ventricle size (p = 0.039). The left ventricular mass index was significantly higher in pre-transplantation group (p < 0.001). The left atrium volume (p = 0.008) and the left ventricular mass index (p t = 0.035) were higher in the post-transplant group. It was observed that the lower the BNP, the lower/more negative the GLS in the post-transplant group (p = 0.038 and r = 0.427). Significant reduction in the overall longitudinal strain of the left ventricle was detected before (p = 0.01) and after liver transplantation (p = 0.019). A subclinical left ventricular systolic dysfunction was evidenced by two-dimensional speckle tracking technique before and after liver transplantation, even when compared to normal values of the last pediatric meta-analysis.Márcio Miranda BritoHelena Thie MiyataniPaulo Renato de Alencar PereiraAna Cristina Aoun TannuriUenis TannuriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Márcio Miranda Brito Helena Thie Miyatani Paulo Renato de Alencar Pereira Ana Cristina Aoun Tannuri Uenis Tannuri Evaluation of ventricular systolic function by speckle tracking technique in patients with biliary atresia before and after liver transplantation
description	Abstract To evaluate the ventricular function of patients with biliary atresia (BA) before and after liver transplantation using two-dimensional speckle tracking. Observational, analytical study with healthy control group, volunteers. We recruited patients from 0 to 18 years old who were candidates for liver transplantation and patients after six months of liver transplantation performed for BA from January 1997 to August 2015 at Children’s Institute of São Paulo University Medical School. The patients were submitted to a complete conventional echocardiographic study. After that, the images were captured for global longitudinal strain (GLS). A blood sample was collected for brain natriuretic peptide (BNP) level. Ejection fraction obtained by Simpson’s method was significantly higher in the hepatic pre-transplantation group (p < 0.001), as well as left atrial size (p < 0.001) and left ventricle size (p = 0.039). The left ventricular mass index was significantly higher in pre-transplantation group (p < 0.001). The left atrium volume (p = 0.008) and the left ventricular mass index (p t = 0.035) were higher in the post-transplant group. It was observed that the lower the BNP, the lower/more negative the GLS in the post-transplant group (p = 0.038 and r = 0.427). Significant reduction in the overall longitudinal strain of the left ventricle was detected before (p = 0.01) and after liver transplantation (p = 0.019). A subclinical left ventricular systolic dysfunction was evidenced by two-dimensional speckle tracking technique before and after liver transplantation, even when compared to normal values of the last pediatric meta-analysis.
format	article
author	Márcio Miranda Brito Helena Thie Miyatani Paulo Renato de Alencar Pereira Ana Cristina Aoun Tannuri Uenis Tannuri
author_facet	Márcio Miranda Brito Helena Thie Miyatani Paulo Renato de Alencar Pereira Ana Cristina Aoun Tannuri Uenis Tannuri
author_sort	Márcio Miranda Brito
title	Evaluation of ventricular systolic function by speckle tracking technique in patients with biliary atresia before and after liver transplantation
title_short	Evaluation of ventricular systolic function by speckle tracking technique in patients with biliary atresia before and after liver transplantation
title_full	Evaluation of ventricular systolic function by speckle tracking technique in patients with biliary atresia before and after liver transplantation
title_fullStr	Evaluation of ventricular systolic function by speckle tracking technique in patients with biliary atresia before and after liver transplantation
title_full_unstemmed	Evaluation of ventricular systolic function by speckle tracking technique in patients with biliary atresia before and after liver transplantation
title_sort	evaluation of ventricular systolic function by speckle tracking technique in patients with biliary atresia before and after liver transplantation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ee472ce14d9f44e28062b2ebf4b15a89
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Evaluation of ventricular systolic function by speckle tracking technique in patients with biliary atresia before and after liver transplantation

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