Effect of Magnesium Sulfate on Epinephrine-Mediated Adverse Effects during Liposuction Procedures: A prospective Randomized controlled Study

Background: During liposuction procedures, injection of wetting solution containing epinephrine is performed. This may increase the risk of cardiovascular side effects in large volume cases. Magnesium sulfate has cardioprotective effects, and can prevent complications related to epinephrine. The ai...

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Autores principales:	Ahmed Sonbol, Sameh Ghareeb
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2021
Materias:	epinephrine magnesium sulfate liposuction arrhythmia norepinephrine Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ee4dfbd718cc4a87a0e72268b422625b
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spelling	oai:doaj.org-article:ee4dfbd718cc4a87a0e72268b422625b2021-12-02T17:16:01ZEffect of Magnesium Sulfate on Epinephrine-Mediated Adverse Effects during Liposuction Procedures: A prospective Randomized controlled Study2636-41742682-378010.21608/ijma.2021.57348.1259https://doaj.org/article/ee4dfbd718cc4a87a0e72268b422625b2021-04-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_158326_42ffc9e649ca77dfa34fb4b4e5ff641e.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: During liposuction procedures, injection of wetting solution containing epinephrine is performed. This may increase the risk of cardiovascular side effects in large volume cases. Magnesium sulfate has cardioprotective effects, and can prevent complications related to epinephrine. The aim of the work: To assess the effect of adding intravenous magnesium sulfate, during the administration of epinephrine containing wetting solution, on the incidence of epinephrine-mediated cardiovascular side effects during liposuction surgery. Patients and Methods: This was a prospective randomized study comprised a total of 94 cases into two equal groups. The epinephrine group included 47 cases that had epinephrine in their wetting solution, and epinephrine-Mg group included the remaining cases that had adrenaline in the wetting solution along with intra venous. administration of MgSO4. Heart rate, blood pressure, arrhythmia incidence, isoflurane, and morphine consumption were recorded. Results: No significant difference was noticed as regard basal and induction heart rate and mean arterial pressure [MAP]. However, the epinephrine-Mg group showed significantly lower readings on subsequent assessment. There was no significant difference among both groups regarding the incidence of arrhythmia; the epinephrine group had more cases with arrhythmia. Isoflurane consumption decreased significantly in the epinephrine-Mg group in comparison with the epinephrine group, while morphine consumption did not significantly differ between them. Conclusion: Based on our findings, intravenous administration of magnesium sulfate decreases heart rate, blood pressure, and inhalational anesthesia consumption during liposuction. However, it has no significant impact neither on the incidence of arrhythmia, nor morphine consumption.Ahmed SonbolSameh GhareebAl-Azhar University, Faculty of Medicine (Damietta)articleepinephrinemagnesium sulfateliposuctionarrhythmianorepinephrineMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 3, Iss 2, Pp 1390-1397 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	epinephrine magnesium sulfate liposuction arrhythmia norepinephrine Medicine (General) R5-920
spellingShingle	epinephrine magnesium sulfate liposuction arrhythmia norepinephrine Medicine (General) R5-920 Ahmed Sonbol Sameh Ghareeb Effect of Magnesium Sulfate on Epinephrine-Mediated Adverse Effects during Liposuction Procedures: A prospective Randomized controlled Study
description	Background: During liposuction procedures, injection of wetting solution containing epinephrine is performed. This may increase the risk of cardiovascular side effects in large volume cases. Magnesium sulfate has cardioprotective effects, and can prevent complications related to epinephrine. The aim of the work: To assess the effect of adding intravenous magnesium sulfate, during the administration of epinephrine containing wetting solution, on the incidence of epinephrine-mediated cardiovascular side effects during liposuction surgery. Patients and Methods: This was a prospective randomized study comprised a total of 94 cases into two equal groups. The epinephrine group included 47 cases that had epinephrine in their wetting solution, and epinephrine-Mg group included the remaining cases that had adrenaline in the wetting solution along with intra venous. administration of MgSO4. Heart rate, blood pressure, arrhythmia incidence, isoflurane, and morphine consumption were recorded. Results: No significant difference was noticed as regard basal and induction heart rate and mean arterial pressure [MAP]. However, the epinephrine-Mg group showed significantly lower readings on subsequent assessment. There was no significant difference among both groups regarding the incidence of arrhythmia; the epinephrine group had more cases with arrhythmia. Isoflurane consumption decreased significantly in the epinephrine-Mg group in comparison with the epinephrine group, while morphine consumption did not significantly differ between them. Conclusion: Based on our findings, intravenous administration of magnesium sulfate decreases heart rate, blood pressure, and inhalational anesthesia consumption during liposuction. However, it has no significant impact neither on the incidence of arrhythmia, nor morphine consumption.
format	article
author	Ahmed Sonbol Sameh Ghareeb
author_facet	Ahmed Sonbol Sameh Ghareeb
author_sort	Ahmed Sonbol
title	Effect of Magnesium Sulfate on Epinephrine-Mediated Adverse Effects during Liposuction Procedures: A prospective Randomized controlled Study
title_short	Effect of Magnesium Sulfate on Epinephrine-Mediated Adverse Effects during Liposuction Procedures: A prospective Randomized controlled Study
title_full	Effect of Magnesium Sulfate on Epinephrine-Mediated Adverse Effects during Liposuction Procedures: A prospective Randomized controlled Study
title_fullStr	Effect of Magnesium Sulfate on Epinephrine-Mediated Adverse Effects during Liposuction Procedures: A prospective Randomized controlled Study
title_full_unstemmed	Effect of Magnesium Sulfate on Epinephrine-Mediated Adverse Effects during Liposuction Procedures: A prospective Randomized controlled Study
title_sort	effect of magnesium sulfate on epinephrine-mediated adverse effects during liposuction procedures: a prospective randomized controlled study
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2021
url	https://doaj.org/article/ee4dfbd718cc4a87a0e72268b422625b
work_keys_str_mv	AT ahmedsonbol effectofmagnesiumsulfateonepinephrinemediatedadverseeffectsduringliposuctionproceduresaprospectiverandomizedcontrolledstudy AT samehghareeb effectofmagnesiumsulfateonepinephrinemediatedadverseeffectsduringliposuctionproceduresaprospectiverandomizedcontrolledstudy
_version_	1718381235694206976

Effect of Magnesium Sulfate on Epinephrine-Mediated Adverse Effects during Liposuction Procedures: A prospective Randomized controlled Study

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