RELATION BETWEEN REGULATORY T CELLS, CA-125 LEVEL AND TUMOR MASS IN OVARIAN CANCER PATIENTS
The relationship between various subpopulations of regulatory T-cells (Treg) and serum level of CA-125 and dynamics of Treg following surgery in ovarian cancer (OC) patients have been investigated. The typical for OC peripheral blood Treg changes (the enchantment of CD4+FoxP3+ и CD8+FoxP3+ T-cells a...
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2014
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oai:doaj.org-article:ee4f25e7fee0475e935f4f2374dddcec2021-11-18T08:03:38ZRELATION BETWEEN REGULATORY T CELLS, CA-125 LEVEL AND TUMOR MASS IN OVARIAN CANCER PATIENTS1563-06252313-741X10.15789/1563-0625-2010-4-5-311-318https://doaj.org/article/ee4f25e7fee0475e935f4f2374dddcec2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/134https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe relationship between various subpopulations of regulatory T-cells (Treg) and serum level of CA-125 and dynamics of Treg following surgery in ovarian cancer (OC) patients have been investigated. The typical for OC peripheral blood Treg changes (the enchantment of CD4+FoxP3+ и CD8+FoxP3+ T-cells and decrease of CD4+CD25+/CD4+CD25high Т-cells due to their migration to ascites) have been revealed only in patients with elevated CA-125 level and were not registered in patient's group with normal level of this antigen. CA-125 serum level was directly correlated to absolute count of CD4+CD25high Т-cells and was in reverse relation to CD8+FoxP3+ T-cells. Surgical removal of a tumor was accompanied by remarkable reduction of CA-125 level in all cases. However Treg changes were observed only in patients with optimal cytoreductive surgery and were evidenced by CD4+CD25+/CD4+CD25high Т-cell normalization, whereas the number of these cells in peripheral blood of patients with residual tumors after surgery remained decreased. At that percentage of CD4+FoxP3+ и CD8+FoxP3+ Т-cells 2 weeks after surgery was unchanged and their increased number was associated with persisted decrease of T-cell proliferation in response to anti-CD3 stimulation.E. R. ChernykhE. V. KurganovaM. A. TikhonovaE. G. LaskavayaV. A. LebedevaA. A. OstaninSPb RAACIarticletregfoxp3+са-125ovarian tumor massImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 4-5, Pp 311-318 (2014) |
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DOAJ |
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| topic |
treg foxp3+ са-125 ovarian tumor mass Immunologic diseases. Allergy RC581-607 |
| spellingShingle |
treg foxp3+ са-125 ovarian tumor mass Immunologic diseases. Allergy RC581-607 E. R. Chernykh E. V. Kurganova M. A. Tikhonova E. G. Laskavaya V. A. Lebedeva A. A. Ostanin RELATION BETWEEN REGULATORY T CELLS, CA-125 LEVEL AND TUMOR MASS IN OVARIAN CANCER PATIENTS |
| description |
The relationship between various subpopulations of regulatory T-cells (Treg) and serum level of CA-125 and dynamics of Treg following surgery in ovarian cancer (OC) patients have been investigated. The typical for OC peripheral blood Treg changes (the enchantment of CD4+FoxP3+ и CD8+FoxP3+ T-cells and decrease of CD4+CD25+/CD4+CD25high Т-cells due to their migration to ascites) have been revealed only in patients with elevated CA-125 level and were not registered in patient's group with normal level of this antigen. CA-125 serum level was directly correlated to absolute count of CD4+CD25high Т-cells and was in reverse relation to CD8+FoxP3+ T-cells. Surgical removal of a tumor was accompanied by remarkable reduction of CA-125 level in all cases. However Treg changes were observed only in patients with optimal cytoreductive surgery and were evidenced by CD4+CD25+/CD4+CD25high Т-cell normalization, whereas the number of these cells in peripheral blood of patients with residual tumors after surgery remained decreased. At that percentage of CD4+FoxP3+ и CD8+FoxP3+ Т-cells 2 weeks after surgery was unchanged and their increased number was associated with persisted decrease of T-cell proliferation in response to anti-CD3 stimulation. |
| format |
article |
| author |
E. R. Chernykh E. V. Kurganova M. A. Tikhonova E. G. Laskavaya V. A. Lebedeva A. A. Ostanin |
| author_facet |
E. R. Chernykh E. V. Kurganova M. A. Tikhonova E. G. Laskavaya V. A. Lebedeva A. A. Ostanin |
| author_sort |
E. R. Chernykh |
| title |
RELATION BETWEEN REGULATORY T CELLS, CA-125 LEVEL AND TUMOR MASS IN OVARIAN CANCER PATIENTS |
| title_short |
RELATION BETWEEN REGULATORY T CELLS, CA-125 LEVEL AND TUMOR MASS IN OVARIAN CANCER PATIENTS |
| title_full |
RELATION BETWEEN REGULATORY T CELLS, CA-125 LEVEL AND TUMOR MASS IN OVARIAN CANCER PATIENTS |
| title_fullStr |
RELATION BETWEEN REGULATORY T CELLS, CA-125 LEVEL AND TUMOR MASS IN OVARIAN CANCER PATIENTS |
| title_full_unstemmed |
RELATION BETWEEN REGULATORY T CELLS, CA-125 LEVEL AND TUMOR MASS IN OVARIAN CANCER PATIENTS |
| title_sort |
relation between regulatory t cells, ca-125 level and tumor mass in ovarian cancer patients |
| publisher |
SPb RAACI |
| publishDate |
2014 |
| url |
https://doaj.org/article/ee4f25e7fee0475e935f4f2374dddcec |
| work_keys_str_mv |
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| _version_ |
1718422578690785280 |