Correlation between neutrophil-to-lymphocyte ratio and postoperative mortality in elderly patients with hip fracture: a meta-analysis

Correlation between neutrophil-to-lymphocyte ratio and postoperative mortality in elderly patients with hip fracture: a meta-analysis

Abstract Introduction The neutrophil-to-lymphocyte ratio (NLR) is a crucial prognosis predictor following several major operations. However, the association between NLR and the outcome after hip fracture surgery is unclear. In this meta-analysis, we investigated the correlation between NLR and posto...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Yu-Hang Chen, Ching-Hsin Chou, Hsin-Hsien Su, Yu-Ting Tsai, Ming-Hsiu Chiang, Yi-Jie Kuo, Yu-Pin Chen
Formato: article
Lenguaje:EN
Publicado: BMC 2021
Materias:
Hip fracture
Neutrophil-to-lymphocyte ratio
Mortality
Orthopedic surgery
RD701-811
Diseases of the musculoskeletal system
RC925-935
Acceso en línea:https://doaj.org/article/ee5013c064824406af8806a7107874c3
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:ee5013c064824406af8806a7107874c3
record_format dspace
spelling oai:doaj.org-article:ee5013c064824406af8806a7107874c32021-11-21T12:29:55ZCorrelation between neutrophil-to-lymphocyte ratio and postoperative mortality in elderly patients with hip fracture: a meta-analysis10.1186/s13018-021-02831-61749-799Xhttps://doaj.org/article/ee5013c064824406af8806a7107874c32021-11-01T00:00:00Zhttps://doi.org/10.1186/s13018-021-02831-6https://doaj.org/toc/1749-799XAbstract Introduction The neutrophil-to-lymphocyte ratio (NLR) is a crucial prognosis predictor following several major operations. However, the association between NLR and the outcome after hip fracture surgery is unclear. In this meta-analysis, we investigated the correlation between NLR and postoperative mortality in geriatric patients following hip surgery. Method PubMed, Embase, Cochrane library, and Google Scholar were searched for studies up to June 2021 reporting the correlation between NLR and postoperative mortality in elderly patients undergoing surgery for hip fracture. Data from studies reporting the mean of NLR and its 95% confidence interval (CI) were pooled. Both long-term (≥ 1 year) and short-term (≤ 30 days) mortality rates were included for analysis. Result Eight retrospective studies comprising a total of 1563 patients were included. Both preoperative and postoperative NLRs (mean difference [MD]: 2.75, 95% CI: 0.23–5.27; P = 0.03 and MD: 2.36, 95% CI: 0.51–4.21; P = 0.01, respectively) were significantly higher in the long-term mortality group than in the long-term survival group. However, no significant differences in NLR were noted between the short-term mortality and survival groups (MD: − 1.02, 95% CI: − 3.98 to 1.93; P = 0.5). Conclusion Higher preoperative and postoperative NLRs were correlated with a higher risk of long-term mortality following surgery for hip fracture in the geriatric population, suggesting the prognostic value of NLR for long-term survival. Further studies with well-controlled confounders are warranted to clarify the predictive value of NLR in clinical practice in geriatric patients with hip fracture.Yu-Hang ChenChing-Hsin ChouHsin-Hsien SuYu-Ting TsaiMing-Hsiu ChiangYi-Jie KuoYu-Pin ChenBMCarticleHip fractureNeutrophil-to-lymphocyte ratioMortalityOrthopedic surgeryRD701-811Diseases of the musculoskeletal systemRC925-935ENJournal of Orthopaedic Surgery and Research, Vol 16, Iss 1, Pp 1-9 (2021)
institution DOAJ
collection DOAJ
language EN
topic Hip fracture
Neutrophil-to-lymphocyte ratio
Mortality
Orthopedic surgery
RD701-811
Diseases of the musculoskeletal system
RC925-935
spellingShingle Hip fracture
Neutrophil-to-lymphocyte ratio
Mortality
Orthopedic surgery
RD701-811
Diseases of the musculoskeletal system
RC925-935
Yu-Hang Chen
Ching-Hsin Chou
Hsin-Hsien Su
Yu-Ting Tsai
Ming-Hsiu Chiang
Yi-Jie Kuo
Yu-Pin Chen
Correlation between neutrophil-to-lymphocyte ratio and postoperative mortality in elderly patients with hip fracture: a meta-analysis
description Abstract Introduction The neutrophil-to-lymphocyte ratio (NLR) is a crucial prognosis predictor following several major operations. However, the association between NLR and the outcome after hip fracture surgery is unclear. In this meta-analysis, we investigated the correlation between NLR and postoperative mortality in geriatric patients following hip surgery. Method PubMed, Embase, Cochrane library, and Google Scholar were searched for studies up to June 2021 reporting the correlation between NLR and postoperative mortality in elderly patients undergoing surgery for hip fracture. Data from studies reporting the mean of NLR and its 95% confidence interval (CI) were pooled. Both long-term (≥ 1 year) and short-term (≤ 30 days) mortality rates were included for analysis. Result Eight retrospective studies comprising a total of 1563 patients were included. Both preoperative and postoperative NLRs (mean difference [MD]: 2.75, 95% CI: 0.23–5.27; P = 0.03 and MD: 2.36, 95% CI: 0.51–4.21; P = 0.01, respectively) were significantly higher in the long-term mortality group than in the long-term survival group. However, no significant differences in NLR were noted between the short-term mortality and survival groups (MD: − 1.02, 95% CI: − 3.98 to 1.93; P = 0.5). Conclusion Higher preoperative and postoperative NLRs were correlated with a higher risk of long-term mortality following surgery for hip fracture in the geriatric population, suggesting the prognostic value of NLR for long-term survival. Further studies with well-controlled confounders are warranted to clarify the predictive value of NLR in clinical practice in geriatric patients with hip fracture.
format article
author Yu-Hang Chen
Ching-Hsin Chou
Hsin-Hsien Su
Yu-Ting Tsai
Ming-Hsiu Chiang
Yi-Jie Kuo
Yu-Pin Chen
author_facet Yu-Hang Chen
Ching-Hsin Chou
Hsin-Hsien Su
Yu-Ting Tsai
Ming-Hsiu Chiang
Yi-Jie Kuo
Yu-Pin Chen
author_sort Yu-Hang Chen
title Correlation between neutrophil-to-lymphocyte ratio and postoperative mortality in elderly patients with hip fracture: a meta-analysis
title_short Correlation between neutrophil-to-lymphocyte ratio and postoperative mortality in elderly patients with hip fracture: a meta-analysis
title_full Correlation between neutrophil-to-lymphocyte ratio and postoperative mortality in elderly patients with hip fracture: a meta-analysis
title_fullStr Correlation between neutrophil-to-lymphocyte ratio and postoperative mortality in elderly patients with hip fracture: a meta-analysis
title_full_unstemmed Correlation between neutrophil-to-lymphocyte ratio and postoperative mortality in elderly patients with hip fracture: a meta-analysis
title_sort correlation between neutrophil-to-lymphocyte ratio and postoperative mortality in elderly patients with hip fracture: a meta-analysis
publisher BMC
publishDate 2021
url https://doaj.org/article/ee5013c064824406af8806a7107874c3
work_keys_str_mv AT yuhangchen correlationbetweenneutrophiltolymphocyteratioandpostoperativemortalityinelderlypatientswithhipfractureametaanalysis
AT chinghsinchou correlationbetweenneutrophiltolymphocyteratioandpostoperativemortalityinelderlypatientswithhipfractureametaanalysis
AT hsinhsiensu correlationbetweenneutrophiltolymphocyteratioandpostoperativemortalityinelderlypatientswithhipfractureametaanalysis
AT yutingtsai correlationbetweenneutrophiltolymphocyteratioandpostoperativemortalityinelderlypatientswithhipfractureametaanalysis
AT minghsiuchiang correlationbetweenneutrophiltolymphocyteratioandpostoperativemortalityinelderlypatientswithhipfractureametaanalysis
AT yijiekuo correlationbetweenneutrophiltolymphocyteratioandpostoperativemortalityinelderlypatientswithhipfractureametaanalysis
AT yupinchen correlationbetweenneutrophiltolymphocyteratioandpostoperativemortalityinelderlypatientswithhipfractureametaanalysis
_version_ 1718418980456103936

Ejemplares similares