scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells

Relationships between DNA methylation and transcription, and methylation and DNA accessibility can be probed but interrogating all three in the same single cells has not been possible. Here, the authors report the first single-cell method for parallel chromatin accessibility, DNA methylation and tra...

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Autores principales:	Stephen J. Clark, Ricard Argelaguet, Chantriolnt-Andreas Kapourani, Thomas M. Stubbs, Heather J. Lee, Celia Alda-Catalinas, Felix Krueger, Guido Sanguinetti, Gavin Kelsey, John C. Marioni, Oliver Stegle, Wolf Reik
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ee5160af085446eb92ec31544e77c471
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spelling	oai:doaj.org-article:ee5160af085446eb92ec31544e77c4712021-12-02T14:40:08ZscNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells10.1038/s41467-018-03149-42041-1723https://doaj.org/article/ee5160af085446eb92ec31544e77c4712018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03149-4https://doaj.org/toc/2041-1723Relationships between DNA methylation and transcription, and methylation and DNA accessibility can be probed but interrogating all three in the same single cells has not been possible. Here, the authors report the first single-cell method for parallel chromatin accessibility, DNA methylation and transcriptome profiling.Stephen J. ClarkRicard ArgelaguetChantriolnt-Andreas KapouraniThomas M. StubbsHeather J. LeeCelia Alda-CatalinasFelix KruegerGuido SanguinettiGavin KelseyJohn C. MarioniOliver StegleWolf ReikNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stephen J. Clark Ricard Argelaguet Chantriolnt-Andreas Kapourani Thomas M. Stubbs Heather J. Lee Celia Alda-Catalinas Felix Krueger Guido Sanguinetti Gavin Kelsey John C. Marioni Oliver Stegle Wolf Reik scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells
description	Relationships between DNA methylation and transcription, and methylation and DNA accessibility can be probed but interrogating all three in the same single cells has not been possible. Here, the authors report the first single-cell method for parallel chromatin accessibility, DNA methylation and transcriptome profiling.
format	article
author	Stephen J. Clark Ricard Argelaguet Chantriolnt-Andreas Kapourani Thomas M. Stubbs Heather J. Lee Celia Alda-Catalinas Felix Krueger Guido Sanguinetti Gavin Kelsey John C. Marioni Oliver Stegle Wolf Reik
author_facet	Stephen J. Clark Ricard Argelaguet Chantriolnt-Andreas Kapourani Thomas M. Stubbs Heather J. Lee Celia Alda-Catalinas Felix Krueger Guido Sanguinetti Gavin Kelsey John C. Marioni Oliver Stegle Wolf Reik
author_sort	Stephen J. Clark
title	scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells
title_short	scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells
title_full	scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells
title_fullStr	scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells
title_full_unstemmed	scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells
title_sort	scnmt-seq enables joint profiling of chromatin accessibility dna methylation and transcription in single cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ee5160af085446eb92ec31544e77c471
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scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells

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