Effects of Wine and Tyrosol on the Lipid Metabolic Profile of Subjects at Risk of Cardiovascular Disease: Potential Cardioprotective Role of Ceramides

Ceramides are a class of sphingolipids which have recently been shown to be better cardiovascular disease (CVD) risk predictors than traditional CVD risk biomarkers. Tyrosol (TYR) is a dietary phenolic compound known to possess cardioprotective effects per se or through its in vivo active metabolite...

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Autores principales:	Jose Rodríguez-Morató, Anna Boronat, Gabriele Serreli, Laura Enríquez, Alex Gomez-Gomez, Oscar J. Pozo, Montserrat Fitó, Rafael de la Torre
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cardiovascular disease ceramides ethanol randomized clinical trial tyrosol white wine Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/ee5522373c454fc7b1a07080a30de47d
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spelling	oai:doaj.org-article:ee5522373c454fc7b1a07080a30de47d2021-11-25T16:25:57ZEffects of Wine and Tyrosol on the Lipid Metabolic Profile of Subjects at Risk of Cardiovascular Disease: Potential Cardioprotective Role of Ceramides10.3390/antiox101116792076-3921https://doaj.org/article/ee5522373c454fc7b1a07080a30de47d2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1679https://doaj.org/toc/2076-3921Ceramides are a class of sphingolipids which have recently been shown to be better cardiovascular disease (CVD) risk predictors than traditional CVD risk biomarkers. Tyrosol (TYR) is a dietary phenolic compound known to possess cardioprotective effects per se or through its in vivo active metabolite hydroxytyrosol. The purpose of this study was to evaluate the effects of the co-administration of white wine (WW) and TYR on circulating levels of ceramides and other lipids in humans at high CVD risk. Volunteers underwent a randomized controlled crossover clinical trial (4-week duration per intervention) with three different interventions: control, WW, and WW enriched with a capsule of TYR (WW + TYR). Endothelial function cardiovascular biomarkers and plasma lipidomic profile were assessed before and after each intervention. It was found that the WW + TYR intervention resulted in lower levels of three ceramide ratios, associated with an improvement of endothelial function (Cer C16:0/Cer C24:0, Cer C18:0/Cer C24:0, and Cer C24:1/Cer C24:0), when compared to the control intervention. Moreover, WW + TYR was able to minimize the alterations in plasma diacylglycerols concentrations observed following WW. Overall, the results obtained show that the antioxidant TYR administered with WW exerts beneficial effects at the cardiovascular level, in part by modulating blood lipid profile.Jose Rodríguez-MoratóAnna BoronatGabriele SerreliLaura EnríquezAlex Gomez-GomezOscar J. PozoMontserrat FitóRafael de la TorreMDPI AGarticlecardiovascular diseaseceramidesethanolrandomized clinical trialtyrosolwhite wineTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1679, p 1679 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardiovascular disease ceramides ethanol randomized clinical trial tyrosol white wine Therapeutics. Pharmacology RM1-950
spellingShingle	cardiovascular disease ceramides ethanol randomized clinical trial tyrosol white wine Therapeutics. Pharmacology RM1-950 Jose Rodríguez-Morató Anna Boronat Gabriele Serreli Laura Enríquez Alex Gomez-Gomez Oscar J. Pozo Montserrat Fitó Rafael de la Torre Effects of Wine and Tyrosol on the Lipid Metabolic Profile of Subjects at Risk of Cardiovascular Disease: Potential Cardioprotective Role of Ceramides
description	Ceramides are a class of sphingolipids which have recently been shown to be better cardiovascular disease (CVD) risk predictors than traditional CVD risk biomarkers. Tyrosol (TYR) is a dietary phenolic compound known to possess cardioprotective effects per se or through its in vivo active metabolite hydroxytyrosol. The purpose of this study was to evaluate the effects of the co-administration of white wine (WW) and TYR on circulating levels of ceramides and other lipids in humans at high CVD risk. Volunteers underwent a randomized controlled crossover clinical trial (4-week duration per intervention) with three different interventions: control, WW, and WW enriched with a capsule of TYR (WW + TYR). Endothelial function cardiovascular biomarkers and plasma lipidomic profile were assessed before and after each intervention. It was found that the WW + TYR intervention resulted in lower levels of three ceramide ratios, associated with an improvement of endothelial function (Cer C16:0/Cer C24:0, Cer C18:0/Cer C24:0, and Cer C24:1/Cer C24:0), when compared to the control intervention. Moreover, WW + TYR was able to minimize the alterations in plasma diacylglycerols concentrations observed following WW. Overall, the results obtained show that the antioxidant TYR administered with WW exerts beneficial effects at the cardiovascular level, in part by modulating blood lipid profile.
format	article
author	Jose Rodríguez-Morató Anna Boronat Gabriele Serreli Laura Enríquez Alex Gomez-Gomez Oscar J. Pozo Montserrat Fitó Rafael de la Torre
author_facet	Jose Rodríguez-Morató Anna Boronat Gabriele Serreli Laura Enríquez Alex Gomez-Gomez Oscar J. Pozo Montserrat Fitó Rafael de la Torre
author_sort	Jose Rodríguez-Morató
title	Effects of Wine and Tyrosol on the Lipid Metabolic Profile of Subjects at Risk of Cardiovascular Disease: Potential Cardioprotective Role of Ceramides
title_short	Effects of Wine and Tyrosol on the Lipid Metabolic Profile of Subjects at Risk of Cardiovascular Disease: Potential Cardioprotective Role of Ceramides
title_full	Effects of Wine and Tyrosol on the Lipid Metabolic Profile of Subjects at Risk of Cardiovascular Disease: Potential Cardioprotective Role of Ceramides
title_fullStr	Effects of Wine and Tyrosol on the Lipid Metabolic Profile of Subjects at Risk of Cardiovascular Disease: Potential Cardioprotective Role of Ceramides
title_full_unstemmed	Effects of Wine and Tyrosol on the Lipid Metabolic Profile of Subjects at Risk of Cardiovascular Disease: Potential Cardioprotective Role of Ceramides
title_sort	effects of wine and tyrosol on the lipid metabolic profile of subjects at risk of cardiovascular disease: potential cardioprotective role of ceramides
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ee5522373c454fc7b1a07080a30de47d
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Effects of Wine and Tyrosol on the Lipid Metabolic Profile of Subjects at Risk of Cardiovascular Disease: Potential Cardioprotective Role of Ceramides

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