Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation

Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation

The underlying mechanisms by which Smad4 loss-of-function accelerates lung cancer metastasis is unclear. Here, the authors show PAK3 as a downstream effector of Smad4 promoting metastatic signalling and suggest Smad4-PAK3 regulation as a point of potential therapy in metastatic lung cancer.

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Autores principales: Xiaohong Tan, Lu Tong, Lin Li, Jinjin Xu, Shaofang Xie, Lei Ji, Junjiang Fu, Qingwu Liu, Shihui Shen, Yun Liu, Yanhui Xiao, Feiran Gao, Robb E. Moses, Nabeel Bardeesy, Yanxiao Wang, Jishuai Zhang, Longying Tang, Lei Li, Kwok-kin Wong, Dianwen Song, Xiao Yang, Jian Liu, Xiaotao Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/ee5586f99b7446ffa59de5f264ead74c
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spelling oai:doaj.org-article:ee5586f99b7446ffa59de5f264ead74c2021-12-02T18:50:56ZLoss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation10.1038/s41467-021-24898-92041-1723https://doaj.org/article/ee5586f99b7446ffa59de5f264ead74c2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24898-9https://doaj.org/toc/2041-1723The underlying mechanisms by which Smad4 loss-of-function accelerates lung cancer metastasis is unclear. Here, the authors show PAK3 as a downstream effector of Smad4 promoting metastatic signalling and suggest Smad4-PAK3 regulation as a point of potential therapy in metastatic lung cancer.Xiaohong TanLu TongLin LiJinjin XuShaofang XieLei JiJunjiang FuQingwu LiuShihui ShenYun LiuYanhui XiaoFeiran GaoRobb E. MosesNabeel BardeesyYanxiao WangJishuai ZhangLongying TangLei LiKwok-kin WongDianwen SongXiao YangJian LiuXiaotao LiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xiaohong Tan
Lu Tong
Lin Li
Jinjin Xu
Shaofang Xie
Lei Ji
Junjiang Fu
Qingwu Liu
Shihui Shen
Yun Liu
Yanhui Xiao
Feiran Gao
Robb E. Moses
Nabeel Bardeesy
Yanxiao Wang
Jishuai Zhang
Longying Tang
Lei Li
Kwok-kin Wong
Dianwen Song
Xiao Yang
Jian Liu
Xiaotao Li
Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation
description The underlying mechanisms by which Smad4 loss-of-function accelerates lung cancer metastasis is unclear. Here, the authors show PAK3 as a downstream effector of Smad4 promoting metastatic signalling and suggest Smad4-PAK3 regulation as a point of potential therapy in metastatic lung cancer.
format article
author Xiaohong Tan
Lu Tong
Lin Li
Jinjin Xu
Shaofang Xie
Lei Ji
Junjiang Fu
Qingwu Liu
Shihui Shen
Yun Liu
Yanhui Xiao
Feiran Gao
Robb E. Moses
Nabeel Bardeesy
Yanxiao Wang
Jishuai Zhang
Longying Tang
Lei Li
Kwok-kin Wong
Dianwen Song
Xiao Yang
Jian Liu
Xiaotao Li
author_facet Xiaohong Tan
Lu Tong
Lin Li
Jinjin Xu
Shaofang Xie
Lei Ji
Junjiang Fu
Qingwu Liu
Shihui Shen
Yun Liu
Yanhui Xiao
Feiran Gao
Robb E. Moses
Nabeel Bardeesy
Yanxiao Wang
Jishuai Zhang
Longying Tang
Lei Li
Kwok-kin Wong
Dianwen Song
Xiao Yang
Jian Liu
Xiaotao Li
author_sort Xiaohong Tan
title Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation
title_short Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation
title_full Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation
title_fullStr Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation
title_full_unstemmed Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation
title_sort loss of smad4 promotes aggressive lung cancer metastasis by de-repression of pak3 via mirna regulation
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/ee5586f99b7446ffa59de5f264ead74c
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