Mitochondrial DNA editing in mice with DddA-TALE fusion deaminases

Mitochondrial DNA editing in mice with DddA-TALE fusion deaminases

Split DddA-derived base editors fused to TALEs enable mitochondrial DNA editing. Here the authors demonstrate their use in mouse embryos with germline transmission.

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Autores principales: Hyunji Lee, Seonghyun Lee, Gayoung Baek, Annie Kim, Beum-Chang Kang, Huiyun Seo, Jin-Soo Kim
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Q
Acceso en línea:https://doaj.org/article/ee5911a6b2f44fcc9054d499322a52a3
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spelling oai:doaj.org-article:ee5911a6b2f44fcc9054d499322a52a32021-12-02T12:11:16ZMitochondrial DNA editing in mice with DddA-TALE fusion deaminases10.1038/s41467-021-21464-12041-1723https://doaj.org/article/ee5911a6b2f44fcc9054d499322a52a32021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21464-1https://doaj.org/toc/2041-1723Split DddA-derived base editors fused to TALEs enable mitochondrial DNA editing. Here the authors demonstrate their use in mouse embryos with germline transmission.Hyunji LeeSeonghyun LeeGayoung BaekAnnie KimBeum-Chang KangHuiyun SeoJin-Soo KimNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-6 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hyunji Lee
Seonghyun Lee
Gayoung Baek
Annie Kim
Beum-Chang Kang
Huiyun Seo
Jin-Soo Kim
Mitochondrial DNA editing in mice with DddA-TALE fusion deaminases
description Split DddA-derived base editors fused to TALEs enable mitochondrial DNA editing. Here the authors demonstrate their use in mouse embryos with germline transmission.
format article
author Hyunji Lee
Seonghyun Lee
Gayoung Baek
Annie Kim
Beum-Chang Kang
Huiyun Seo
Jin-Soo Kim
author_facet Hyunji Lee
Seonghyun Lee
Gayoung Baek
Annie Kim
Beum-Chang Kang
Huiyun Seo
Jin-Soo Kim
author_sort Hyunji Lee
title Mitochondrial DNA editing in mice with DddA-TALE fusion deaminases
title_short Mitochondrial DNA editing in mice with DddA-TALE fusion deaminases
title_full Mitochondrial DNA editing in mice with DddA-TALE fusion deaminases
title_fullStr Mitochondrial DNA editing in mice with DddA-TALE fusion deaminases
title_full_unstemmed Mitochondrial DNA editing in mice with DddA-TALE fusion deaminases
title_sort mitochondrial dna editing in mice with ddda-tale fusion deaminases
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/ee5911a6b2f44fcc9054d499322a52a3
work_keys_str_mv AT hyunjilee mitochondrialdnaeditinginmicewithdddatalefusiondeaminases
AT seonghyunlee mitochondrialdnaeditinginmicewithdddatalefusiondeaminases
AT gayoungbaek mitochondrialdnaeditinginmicewithdddatalefusiondeaminases
AT anniekim mitochondrialdnaeditinginmicewithdddatalefusiondeaminases
AT beumchangkang mitochondrialdnaeditinginmicewithdddatalefusiondeaminases
AT huiyunseo mitochondrialdnaeditinginmicewithdddatalefusiondeaminases
AT jinsookim mitochondrialdnaeditinginmicewithdddatalefusiondeaminases
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