Pharmacodynamics of the Orotomides against <italic toggle="yes">Aspergillus fumigatus</italic>: New Opportunities for Treatment of Multidrug-Resistant Fungal Disease

Pharmacodynamics of the Orotomides against <italic toggle="yes">Aspergillus fumigatus</italic>: New Opportunities for Treatment of Multidrug-Resistant Fungal Disease

ABSTRACT F901318 is an antifungal agent with a novel mechanism of action and potent activity against Aspergillus spp. An understanding of the pharmacodynamics (PD) of F901318 is required for selection of effective regimens for study in phase II and III clinical trials. Neutropenic murine and rabbit...

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Bibliographic Details
Main Authors: William W. Hope, Laura McEntee, Joanne Livermore, Sarah Whalley, Adam Johnson, Nicola Farrington, Ruwanthi Kolamunnage-Dona, Julie Schwartz, Anthony Kennedy, Derek Law, Michael Birch, John H. Rex
Format: article
Language:EN
Published: American Society for Microbiology 2017
Subjects:
Aspergillus fumigatus
antifungal agents
antifungal resistance
antifungal susceptibility testing
drug discovery
laboratory animals
Microbiology
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Online Access:https://doaj.org/article/ee5b4c0c99644111aad9e0e94bbbb141
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https://doaj.org/article/ee5b4c0c99644111aad9e0e94bbbb141

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