Effect of modest caloric restriction on oxidative stress in women, a randomized trial.

<h4>Objectives</h4>It is not established to what extent caloric intake must be reduced to lower oxidative stress in humans. The aim of this study was to determine the effect of short-term, moderate caloric restriction on markers of oxidative stress and inflammation in overweight and obes...

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Autores principales:	Maciej S Buchowski, Nobuko Hongu, Sari Acra, Li Wang, Joshua Warolin, L Jackson Roberts
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ee5b90ab1cc14728990523ac23a1a160
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spelling	oai:doaj.org-article:ee5b90ab1cc14728990523ac23a1a1602021-11-18T08:13:00ZEffect of modest caloric restriction on oxidative stress in women, a randomized trial.1932-620310.1371/journal.pone.0047079https://doaj.org/article/ee5b90ab1cc14728990523ac23a1a1602012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23071718/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objectives</h4>It is not established to what extent caloric intake must be reduced to lower oxidative stress in humans. The aim of this study was to determine the effect of short-term, moderate caloric restriction on markers of oxidative stress and inflammation in overweight and obese premenopausal women.<h4>Materials/methods</h4>Randomized trial comparison of 25% caloric restriction (CR) or control diet in 40 overweight or obese women (body mass index 32±5.8 kg/m(2)) observed for 28 days and followed for the next 90 days. Weight, anthropometry, validated markers of oxidative stress (F(2)-isoprostane) and inflammation (C-reactive protein), adipokines, hormones, lipids, interleukins, and blood pressure were assessed at baseline, during the intervention, and at follow-up.<h4>Results</h4>Baseline median F(2)-isoprostane concentration (57.0, IQR = 40.5-79.5) in the CR group was 1.75-fold above average range for normal weight women (32.5 pg/ml). After starting of the caloric restriction diet, F(2)-isoprostane levels fell rapidly in the CR group, reaching statistical difference from the control group by day 5 (median 33.5, IQR = 26.0-48.0, P<0.001) and remained suppressed while continuing on the caloric restriction diet. Three months after resuming a habitual diet, concentrations of F(2)-isoprostane returned to baseline elevated levels in ∼80% of the women.<h4>Conclusions</h4>Oxidative stress can be rapidly reduced and sustained through a modest reduction in caloric intake suggesting potential health benefits in overweight and obese women.<h4>Trial registration</h4>Clinicaltrials.gov NCT00808275.Maciej S BuchowskiNobuko HonguSari AcraLi WangJoshua WarolinL Jackson RobertsPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e47079 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maciej S Buchowski Nobuko Hongu Sari Acra Li Wang Joshua Warolin L Jackson Roberts Effect of modest caloric restriction on oxidative stress in women, a randomized trial.
description	<h4>Objectives</h4>It is not established to what extent caloric intake must be reduced to lower oxidative stress in humans. The aim of this study was to determine the effect of short-term, moderate caloric restriction on markers of oxidative stress and inflammation in overweight and obese premenopausal women.<h4>Materials/methods</h4>Randomized trial comparison of 25% caloric restriction (CR) or control diet in 40 overweight or obese women (body mass index 32±5.8 kg/m(2)) observed for 28 days and followed for the next 90 days. Weight, anthropometry, validated markers of oxidative stress (F(2)-isoprostane) and inflammation (C-reactive protein), adipokines, hormones, lipids, interleukins, and blood pressure were assessed at baseline, during the intervention, and at follow-up.<h4>Results</h4>Baseline median F(2)-isoprostane concentration (57.0, IQR = 40.5-79.5) in the CR group was 1.75-fold above average range for normal weight women (32.5 pg/ml). After starting of the caloric restriction diet, F(2)-isoprostane levels fell rapidly in the CR group, reaching statistical difference from the control group by day 5 (median 33.5, IQR = 26.0-48.0, P<0.001) and remained suppressed while continuing on the caloric restriction diet. Three months after resuming a habitual diet, concentrations of F(2)-isoprostane returned to baseline elevated levels in ∼80% of the women.<h4>Conclusions</h4>Oxidative stress can be rapidly reduced and sustained through a modest reduction in caloric intake suggesting potential health benefits in overweight and obese women.<h4>Trial registration</h4>Clinicaltrials.gov NCT00808275.
format	article
author	Maciej S Buchowski Nobuko Hongu Sari Acra Li Wang Joshua Warolin L Jackson Roberts
author_facet	Maciej S Buchowski Nobuko Hongu Sari Acra Li Wang Joshua Warolin L Jackson Roberts
author_sort	Maciej S Buchowski
title	Effect of modest caloric restriction on oxidative stress in women, a randomized trial.
title_short	Effect of modest caloric restriction on oxidative stress in women, a randomized trial.
title_full	Effect of modest caloric restriction on oxidative stress in women, a randomized trial.
title_fullStr	Effect of modest caloric restriction on oxidative stress in women, a randomized trial.
title_full_unstemmed	Effect of modest caloric restriction on oxidative stress in women, a randomized trial.
title_sort	effect of modest caloric restriction on oxidative stress in women, a randomized trial.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/ee5b90ab1cc14728990523ac23a1a160
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Effect of modest caloric restriction on oxidative stress in women, a randomized trial.

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