Telomeric TART elements target the piRNA machinery in Drosophila.

Coevolution between transposable elements (TEs) and their hosts can be antagonistic, where TEs evolve to avoid silencing and the host responds by reestablishing TE suppression, or mutualistic, where TEs are co-opted to benefit their host. The TART-A TE functions as an important component of Drosophi...

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Autores principales:	Christopher E Ellison, Meenakshi S Kagda, Weihuan Cao
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2020
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ee5cf49cb66647c29b3621b92ae65864
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spelling	oai:doaj.org-article:ee5cf49cb66647c29b3621b92ae658642021-12-02T19:54:18ZTelomeric TART elements target the piRNA machinery in Drosophila.1544-91731545-788510.1371/journal.pbio.3000689https://doaj.org/article/ee5cf49cb66647c29b3621b92ae658642020-12-01T00:00:00Zhttps://doi.org/10.1371/journal.pbio.3000689https://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Coevolution between transposable elements (TEs) and their hosts can be antagonistic, where TEs evolve to avoid silencing and the host responds by reestablishing TE suppression, or mutualistic, where TEs are co-opted to benefit their host. The TART-A TE functions as an important component of Drosophila telomeres but has also reportedly inserted into the Drosophila melanogaster nuclear export factor gene nxf2. We find that, rather than inserting into nxf2, TART-A has actually captured a portion of nxf2 sequence. We show that TART-A produces abundant Piwi-interacting small RNAs (piRNAs), some of which are antisense to the nxf2 transcript, and that the TART-like region of nxf2 is evolving rapidly. Furthermore, in D. melanogaster, TART-A is present at higher copy numbers, and nxf2 shows reduced expression, compared to the closely related species Drosophila simulans. We propose that capturing nxf2 sequence allowed TART-A to target the nxf2 gene for piRNA-mediated repression and that these 2 elements are engaged in antagonistic coevolution despite the fact that TART-A is serving a critical role for its host genome.Christopher E EllisonMeenakshi S KagdaWeihuan CaoPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 18, Iss 12, p e3000689 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Christopher E Ellison Meenakshi S Kagda Weihuan Cao Telomeric TART elements target the piRNA machinery in Drosophila.
description	Coevolution between transposable elements (TEs) and their hosts can be antagonistic, where TEs evolve to avoid silencing and the host responds by reestablishing TE suppression, or mutualistic, where TEs are co-opted to benefit their host. The TART-A TE functions as an important component of Drosophila telomeres but has also reportedly inserted into the Drosophila melanogaster nuclear export factor gene nxf2. We find that, rather than inserting into nxf2, TART-A has actually captured a portion of nxf2 sequence. We show that TART-A produces abundant Piwi-interacting small RNAs (piRNAs), some of which are antisense to the nxf2 transcript, and that the TART-like region of nxf2 is evolving rapidly. Furthermore, in D. melanogaster, TART-A is present at higher copy numbers, and nxf2 shows reduced expression, compared to the closely related species Drosophila simulans. We propose that capturing nxf2 sequence allowed TART-A to target the nxf2 gene for piRNA-mediated repression and that these 2 elements are engaged in antagonistic coevolution despite the fact that TART-A is serving a critical role for its host genome.
format	article
author	Christopher E Ellison Meenakshi S Kagda Weihuan Cao
author_facet	Christopher E Ellison Meenakshi S Kagda Weihuan Cao
author_sort	Christopher E Ellison
title	Telomeric TART elements target the piRNA machinery in Drosophila.
title_short	Telomeric TART elements target the piRNA machinery in Drosophila.
title_full	Telomeric TART elements target the piRNA machinery in Drosophila.
title_fullStr	Telomeric TART elements target the piRNA machinery in Drosophila.
title_full_unstemmed	Telomeric TART elements target the piRNA machinery in Drosophila.
title_sort	telomeric tart elements target the pirna machinery in drosophila.
publisher	Public Library of Science (PLoS)
publishDate	2020
url	https://doaj.org/article/ee5cf49cb66647c29b3621b92ae65864
work_keys_str_mv	AT christophereellison telomerictartelementstargetthepirnamachineryindrosophila AT meenakshiskagda telomerictartelementstargetthepirnamachineryindrosophila AT weihuancao telomerictartelementstargetthepirnamachineryindrosophila
_version_	1718375937371799552

Telomeric TART elements target the piRNA machinery in Drosophila.

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