Red meat intake is associated with early onset of rheumatoid arthritis: a cross-sectional study
Abstract Accumulating evidence has implicated dietary factors as important risks for rheumatoid arthritis (RA) development, but analyses of the effects of red meat consumption on RA have yielded diverging results. The aim of this study was to explore the association between red meat and RA in a larg...
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Nature Portfolio
2021
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oai:doaj.org-article:ee5ee77b621148619df8ae48fef051792021-12-02T11:37:27ZRed meat intake is associated with early onset of rheumatoid arthritis: a cross-sectional study10.1038/s41598-021-85035-62045-2322https://doaj.org/article/ee5ee77b621148619df8ae48fef051792021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85035-6https://doaj.org/toc/2045-2322Abstract Accumulating evidence has implicated dietary factors as important risks for rheumatoid arthritis (RA) development, but analyses of the effects of red meat consumption on RA have yielded diverging results. The aim of this study was to explore the association between red meat and RA in a large-scale, cross-sectional study. From June to December 2016, a total of 733 patients were investigated, from which 707 participants were included in the analysis. These patients were divided into two groups according to their consumption of red meat (< 100 g/day; ≥ 100 g/day). The intake of red meat was assessed via physician-administered questionnaire. Generalized linear models were used to analyze relationships between the red meat intake and RA, adjusting for potential confounders including demographic, clinical, laboratory, and other dietary factors. Compared with low-intake red meat RA patients, high-intake red meat patients had an earlier onset age (p = 0.02) and had higher BMI (p = 0.003). The age at disease onset for the high-intake patients was 6.46 years earlier than for low-intake patients, after adjustment for demographic and other possible confounders (β = − 6.46, 95% CI − 9.77, − 3.15; p = 0.0001). Further, stratified analyses showed that this inverse association of red meat intake with RA onset age was especially evident in smokers and overweight patients (BMI ≥ 24 kg/m2). In conclusion, high-intake red meat is associated with early onset of RA, especially in smokers or overweight patients. The findings indicate that eating less red meat could be a recommendation given to patients at risk for RA development.Jiayang JinJing LiYuzhou GanJiajia LiuXiaozhen ZhaoJiali ChenRuijun ZhangYan ZhongXiaomei ChenLijun WuXiaohong XiangYunshan ZhouJing HeJianping GuoXu LiuZhanguo LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021) |
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DOAJ |
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Medicine R Science Q |
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Medicine R Science Q Jiayang Jin Jing Li Yuzhou Gan Jiajia Liu Xiaozhen Zhao Jiali Chen Ruijun Zhang Yan Zhong Xiaomei Chen Lijun Wu Xiaohong Xiang Yunshan Zhou Jing He Jianping Guo Xu Liu Zhanguo Li Red meat intake is associated with early onset of rheumatoid arthritis: a cross-sectional study |
| description |
Abstract Accumulating evidence has implicated dietary factors as important risks for rheumatoid arthritis (RA) development, but analyses of the effects of red meat consumption on RA have yielded diverging results. The aim of this study was to explore the association between red meat and RA in a large-scale, cross-sectional study. From June to December 2016, a total of 733 patients were investigated, from which 707 participants were included in the analysis. These patients were divided into two groups according to their consumption of red meat (< 100 g/day; ≥ 100 g/day). The intake of red meat was assessed via physician-administered questionnaire. Generalized linear models were used to analyze relationships between the red meat intake and RA, adjusting for potential confounders including demographic, clinical, laboratory, and other dietary factors. Compared with low-intake red meat RA patients, high-intake red meat patients had an earlier onset age (p = 0.02) and had higher BMI (p = 0.003). The age at disease onset for the high-intake patients was 6.46 years earlier than for low-intake patients, after adjustment for demographic and other possible confounders (β = − 6.46, 95% CI − 9.77, − 3.15; p = 0.0001). Further, stratified analyses showed that this inverse association of red meat intake with RA onset age was especially evident in smokers and overweight patients (BMI ≥ 24 kg/m2). In conclusion, high-intake red meat is associated with early onset of RA, especially in smokers or overweight patients. The findings indicate that eating less red meat could be a recommendation given to patients at risk for RA development. |
| format |
article |
| author |
Jiayang Jin Jing Li Yuzhou Gan Jiajia Liu Xiaozhen Zhao Jiali Chen Ruijun Zhang Yan Zhong Xiaomei Chen Lijun Wu Xiaohong Xiang Yunshan Zhou Jing He Jianping Guo Xu Liu Zhanguo Li |
| author_facet |
Jiayang Jin Jing Li Yuzhou Gan Jiajia Liu Xiaozhen Zhao Jiali Chen Ruijun Zhang Yan Zhong Xiaomei Chen Lijun Wu Xiaohong Xiang Yunshan Zhou Jing He Jianping Guo Xu Liu Zhanguo Li |
| author_sort |
Jiayang Jin |
| title |
Red meat intake is associated with early onset of rheumatoid arthritis: a cross-sectional study |
| title_short |
Red meat intake is associated with early onset of rheumatoid arthritis: a cross-sectional study |
| title_full |
Red meat intake is associated with early onset of rheumatoid arthritis: a cross-sectional study |
| title_fullStr |
Red meat intake is associated with early onset of rheumatoid arthritis: a cross-sectional study |
| title_full_unstemmed |
Red meat intake is associated with early onset of rheumatoid arthritis: a cross-sectional study |
| title_sort |
red meat intake is associated with early onset of rheumatoid arthritis: a cross-sectional study |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/ee5ee77b621148619df8ae48fef05179 |
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