Anaplastic thyroid carcinoma - current issues of today (according to NCCN Guidelines)

Aim.To consider the current state of the problem of treatment patients with anaplastic thyroid carcinoma. Material and Methods. Twenty-one cases of anaplastic thyroid carcinoma were analyzed in patients from the Lviv Regional Clinical Hospital (n=9) and Lviv Regional Treatment and Diagnostical Ca...

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Autores principales:	O.O. Halay, B.T. Bilynsky, O.R. Duda, R.R. Slipetsky, M.R. Schmidt
Formato:	article
Lenguaje:	EN UK
Publicado:	Danylo Halytsky Lviv National Medical University 2019
Materias:	anaplastic thyroid carcinoma, nccn guidelines Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ee613ccb4ecc4aeab7723a3fa2f88304
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spelling	oai:doaj.org-article:ee613ccb4ecc4aeab7723a3fa2f883042021-11-10T19:49:51ZAnaplastic thyroid carcinoma - current issues of today (according to NCCN Guidelines)1029-42442415-330310.25040/aml2019.01.076https://doaj.org/article/ee613ccb4ecc4aeab7723a3fa2f883042019-02-01T00:00:00Zhttps://amljournal.com/index.php/journal/article/view/78https://doaj.org/toc/1029-4244https://doaj.org/toc/2415-3303Aim.To consider the current state of the problem of treatment patients with anaplastic thyroid carcinoma. Material and Methods. Twenty-one cases of anaplastic thyroid carcinoma were analyzed in patients from the Lviv Regional Clinical Hospital (n=9) and Lviv Regional Treatment and Diagnostical Cancer Center (n = 12) from 2004 to 2017. The approaches to treatment of anaplastic thyroid carcinoma on the basis of NCCN Guidelines over the year of 2018 are shown. Results and Discussion. Anaplastic thyroid carcinoma was more common in women - 15 cases (71,4%) than in men - 6 cases (28,6%). A diagnosis of anaplastic thyroid carcinoma was established as a result of core-biopsy in 12 (57,1%) patients; in 9 (42,9%) cases the verification was obtained after surgery. The average age of patients at the time of diagnosis was 70,9±7,5 years. Radical thyroidectomy was performed in 5 (23,8%) patients. Palliative radiation therapy was used in 3 (14,3%) patients; 4 patients had combined treatment - thyroidectomy and postoperative course of radiation therapy. Remaining 9 (42,9%) cases had symptomatic therapy; out of those, in 2 cases tracheostomy was performed due to a compression of the upper respiratory tract by the tumor. In general, there was no relationship between the type of performed treatment and the overall survival rate of the patients (р>0,05). In our study, the average of survival time was 4,2±3,9 months, and the one-year survival rate was 9,5% (n = 2). Conclusions. The results of treatment for patients with anaplastic thyroid carcinoma are currently unsatisfactory - median overall survival is only 3 months, although these data are consistent with world literature. Factors provoking this disease are not detected, and the mechanisms leading to transformation of differentiated cancer to anaplastic are not defined. All these facts require further study and clinical research.O.O. HalayB.T. BilynskyO.R. DudaR.R. SlipetskyM.R. SchmidtDanylo Halytsky Lviv National Medical Universityarticleanaplastic thyroid carcinoma, nccn guidelinesMedicine (General)R5-920ENUKActa Medica Leopoliensia, Vol 25, Iss 1, Pp 76-81 (2019)
institution	DOAJ
collection	DOAJ
language	EN UK
topic	anaplastic thyroid carcinoma, nccn guidelines Medicine (General) R5-920
spellingShingle	anaplastic thyroid carcinoma, nccn guidelines Medicine (General) R5-920 O.O. Halay B.T. Bilynsky O.R. Duda R.R. Slipetsky M.R. Schmidt Anaplastic thyroid carcinoma - current issues of today (according to NCCN Guidelines)
description	Aim.To consider the current state of the problem of treatment patients with anaplastic thyroid carcinoma. Material and Methods. Twenty-one cases of anaplastic thyroid carcinoma were analyzed in patients from the Lviv Regional Clinical Hospital (n=9) and Lviv Regional Treatment and Diagnostical Cancer Center (n = 12) from 2004 to 2017. The approaches to treatment of anaplastic thyroid carcinoma on the basis of NCCN Guidelines over the year of 2018 are shown. Results and Discussion. Anaplastic thyroid carcinoma was more common in women - 15 cases (71,4%) than in men - 6 cases (28,6%). A diagnosis of anaplastic thyroid carcinoma was established as a result of core-biopsy in 12 (57,1%) patients; in 9 (42,9%) cases the verification was obtained after surgery. The average age of patients at the time of diagnosis was 70,9±7,5 years. Radical thyroidectomy was performed in 5 (23,8%) patients. Palliative radiation therapy was used in 3 (14,3%) patients; 4 patients had combined treatment - thyroidectomy and postoperative course of radiation therapy. Remaining 9 (42,9%) cases had symptomatic therapy; out of those, in 2 cases tracheostomy was performed due to a compression of the upper respiratory tract by the tumor. In general, there was no relationship between the type of performed treatment and the overall survival rate of the patients (р>0,05). In our study, the average of survival time was 4,2±3,9 months, and the one-year survival rate was 9,5% (n = 2). Conclusions. The results of treatment for patients with anaplastic thyroid carcinoma are currently unsatisfactory - median overall survival is only 3 months, although these data are consistent with world literature. Factors provoking this disease are not detected, and the mechanisms leading to transformation of differentiated cancer to anaplastic are not defined. All these facts require further study and clinical research.
format	article
author	O.O. Halay B.T. Bilynsky O.R. Duda R.R. Slipetsky M.R. Schmidt
author_facet	O.O. Halay B.T. Bilynsky O.R. Duda R.R. Slipetsky M.R. Schmidt
author_sort	O.O. Halay
title	Anaplastic thyroid carcinoma - current issues of today (according to NCCN Guidelines)
title_short	Anaplastic thyroid carcinoma - current issues of today (according to NCCN Guidelines)
title_full	Anaplastic thyroid carcinoma - current issues of today (according to NCCN Guidelines)
title_fullStr	Anaplastic thyroid carcinoma - current issues of today (according to NCCN Guidelines)
title_full_unstemmed	Anaplastic thyroid carcinoma - current issues of today (according to NCCN Guidelines)
title_sort	anaplastic thyroid carcinoma - current issues of today (according to nccn guidelines)
publisher	Danylo Halytsky Lviv National Medical University
publishDate	2019
url	https://doaj.org/article/ee613ccb4ecc4aeab7723a3fa2f88304
work_keys_str_mv	AT oohalay anaplasticthyroidcarcinomacurrentissuesoftodayaccordingtonccnguidelines AT btbilynsky anaplasticthyroidcarcinomacurrentissuesoftodayaccordingtonccnguidelines AT orduda anaplasticthyroidcarcinomacurrentissuesoftodayaccordingtonccnguidelines AT rrslipetsky anaplasticthyroidcarcinomacurrentissuesoftodayaccordingtonccnguidelines AT mrschmidt anaplasticthyroidcarcinomacurrentissuesoftodayaccordingtonccnguidelines
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Anaplastic thyroid carcinoma - current issues of today (according to NCCN Guidelines)

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