Diaportones A–C: Three New Metabolites From Endophytic Fungus Diaporthe foeniculina BZM-15

Phytochemical investigation of Diaporthe foeniculina BZM-15 led to one new γ-butyrolactone derivative, diaportone A (1), one cyclopentenone derivative, diaportone B (3), and one monoterpene derivative, diaportone C (5), along with six known compounds (2, 4, and 6–9). Their structures as well as the...

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Autores principales:	Fenghua Kang, Xiuxiang Lu, Sha Zhang, Dekun Chen, Min Kuang, Weiwei Peng, Jianbing Tan, Kangping Xu, Zhenxing Zou, Haibo Tan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	endophytic fungus Diaporthe foeniculina Leptospermum brachyandrum diaportone structure elucidation cytotoxicity Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/ee63e30c8e224f488d0cd38e30f33ac9
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spelling	oai:doaj.org-article:ee63e30c8e224f488d0cd38e30f33ac92021-11-19T05:44:21ZDiaportones A–C: Three New Metabolites From Endophytic Fungus Diaporthe foeniculina BZM-152296-264610.3389/fchem.2021.755351https://doaj.org/article/ee63e30c8e224f488d0cd38e30f33ac92021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fchem.2021.755351/fullhttps://doaj.org/toc/2296-2646Phytochemical investigation of Diaporthe foeniculina BZM-15 led to one new γ-butyrolactone derivative, diaportone A (1), one cyclopentenone derivative, diaportone B (3), and one monoterpene derivative, diaportone C (5), along with six known compounds (2, 4, and 6–9). Their structures as well as the absolute configurations were characterized by means of NMR, HRESIMS, and ECD spectroscopy and quantum chemistry calculation, respectively. Furthermore, all compounds were evaluated for their cytotoxic activity and antibacterial activity, and compounds 7 and 8 displayed significant antiproliferative effects on three human cancer cell lines (SF-268, MCF-7, and HepG2) with IC50 values ranging from 3.6 to 15.8 μM.Fenghua KangFenghua KangXiuxiang LuSha ZhangSha ZhangDekun ChenDekun ChenMin KuangMin KuangWeiwei PengWeiwei PengJianbing TanJianbing TanKangping XuKangping XuZhenxing ZouZhenxing ZouHaibo TanHaibo TanHaibo TanFrontiers Media S.A.articleendophytic fungusDiaporthe foeniculinaLeptospermum brachyandrumdiaportonestructure elucidationcytotoxicityChemistryQD1-999ENFrontiers in Chemistry, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	endophytic fungus Diaporthe foeniculina Leptospermum brachyandrum diaportone structure elucidation cytotoxicity Chemistry QD1-999
spellingShingle	endophytic fungus Diaporthe foeniculina Leptospermum brachyandrum diaportone structure elucidation cytotoxicity Chemistry QD1-999 Fenghua Kang Fenghua Kang Xiuxiang Lu Sha Zhang Sha Zhang Dekun Chen Dekun Chen Min Kuang Min Kuang Weiwei Peng Weiwei Peng Jianbing Tan Jianbing Tan Kangping Xu Kangping Xu Zhenxing Zou Zhenxing Zou Haibo Tan Haibo Tan Haibo Tan Diaportones A–C: Three New Metabolites From Endophytic Fungus Diaporthe foeniculina BZM-15
description	Phytochemical investigation of Diaporthe foeniculina BZM-15 led to one new γ-butyrolactone derivative, diaportone A (1), one cyclopentenone derivative, diaportone B (3), and one monoterpene derivative, diaportone C (5), along with six known compounds (2, 4, and 6–9). Their structures as well as the absolute configurations were characterized by means of NMR, HRESIMS, and ECD spectroscopy and quantum chemistry calculation, respectively. Furthermore, all compounds were evaluated for their cytotoxic activity and antibacterial activity, and compounds 7 and 8 displayed significant antiproliferative effects on three human cancer cell lines (SF-268, MCF-7, and HepG2) with IC50 values ranging from 3.6 to 15.8 μM.
format	article
author	Fenghua Kang Fenghua Kang Xiuxiang Lu Sha Zhang Sha Zhang Dekun Chen Dekun Chen Min Kuang Min Kuang Weiwei Peng Weiwei Peng Jianbing Tan Jianbing Tan Kangping Xu Kangping Xu Zhenxing Zou Zhenxing Zou Haibo Tan Haibo Tan Haibo Tan
author_facet	Fenghua Kang Fenghua Kang Xiuxiang Lu Sha Zhang Sha Zhang Dekun Chen Dekun Chen Min Kuang Min Kuang Weiwei Peng Weiwei Peng Jianbing Tan Jianbing Tan Kangping Xu Kangping Xu Zhenxing Zou Zhenxing Zou Haibo Tan Haibo Tan Haibo Tan
author_sort	Fenghua Kang
title	Diaportones A–C: Three New Metabolites From Endophytic Fungus Diaporthe foeniculina BZM-15
title_short	Diaportones A–C: Three New Metabolites From Endophytic Fungus Diaporthe foeniculina BZM-15
title_full	Diaportones A–C: Three New Metabolites From Endophytic Fungus Diaporthe foeniculina BZM-15
title_fullStr	Diaportones A–C: Three New Metabolites From Endophytic Fungus Diaporthe foeniculina BZM-15
title_full_unstemmed	Diaportones A–C: Three New Metabolites From Endophytic Fungus Diaporthe foeniculina BZM-15
title_sort	diaportones a–c: three new metabolites from endophytic fungus diaporthe foeniculina bzm-15
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ee63e30c8e224f488d0cd38e30f33ac9
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Diaportones A–C: Three New Metabolites From Endophytic Fungus Diaporthe foeniculina BZM-15

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