The rapid growth of fibroids during early pregnancy.

Several studies aimed to disentangle whether pregnancy influences the growth of uterine fibroids but results were inconsistent. In this study, we speculated that fibroid enlargement during pregnancy may not be linear and we hypothesized that this phenomenon may mainly occur during initial pregnancy....

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Autores principales:	Laura Benaglia, Lucia Cardellicchio, Francesca Filippi, Alessio Paffoni, Paolo Vercellini, Edgardo Somigliana, Luigi Fedele
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ee69162fd5d441e7bd19779e4114ab15
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spelling	oai:doaj.org-article:ee69162fd5d441e7bd19779e4114ab152021-11-18T08:37:13ZThe rapid growth of fibroids during early pregnancy.1932-620310.1371/journal.pone.0085933https://doaj.org/article/ee69162fd5d441e7bd19779e4114ab152014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24465797/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Several studies aimed to disentangle whether pregnancy influences the growth of uterine fibroids but results were inconsistent. In this study, we speculated that fibroid enlargement during pregnancy may not be linear and we hypothesized that this phenomenon may mainly occur during initial pregnancy. To test this hypothesis, we set up a prospective cohort study of women with fibroids undergoing IVF. Cases were women achieving a viable pregnancy. Controls were the subsequent women with fibroids but failing to become pregnant. Twenty-five cases and 25 controls were recruited. The total number of fibroids in the two groups was 46 and 41, respectively. The mean ± SD diameter of the fibroids was 17 ± 10 and 20 ± 11 mm, respectively (p = 0.18). A statistically significant enlargement emerged exclusively in pregnant women. The median (Interquartile Range) modification of the diameter of the lesions in cases and controls was +34% (+6%/+65%) and +2% (-6%/+12%), respectively (p<0.001). The median (Interquartile Range) modification of the volume of the lesions was +140% (+23%/+357%) and 0% (-18%/+37%), respectively (p<0.001). In pregnant women, we failed to document any significant correlation between the magnitude of the growth and ovarian responsiveness to hyper-stimulation, suggesting that steroids hormones are not the unique factors involved. In conclusion, fibroids undergo a rapid and remarkable growth during initial pregnancy. Reasons behind this phenomenon remain to be clarified. The early rise in steroids hormones during early pregnancy may not be sufficient to explain the process. Other pregnancy-related hormones and proteins may play also key roles.Laura BenagliaLucia CardellicchioFrancesca FilippiAlessio PaffoniPaolo VercelliniEdgardo SomiglianaLuigi FedelePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e85933 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Laura Benaglia Lucia Cardellicchio Francesca Filippi Alessio Paffoni Paolo Vercellini Edgardo Somigliana Luigi Fedele The rapid growth of fibroids during early pregnancy.
description	Several studies aimed to disentangle whether pregnancy influences the growth of uterine fibroids but results were inconsistent. In this study, we speculated that fibroid enlargement during pregnancy may not be linear and we hypothesized that this phenomenon may mainly occur during initial pregnancy. To test this hypothesis, we set up a prospective cohort study of women with fibroids undergoing IVF. Cases were women achieving a viable pregnancy. Controls were the subsequent women with fibroids but failing to become pregnant. Twenty-five cases and 25 controls were recruited. The total number of fibroids in the two groups was 46 and 41, respectively. The mean ± SD diameter of the fibroids was 17 ± 10 and 20 ± 11 mm, respectively (p = 0.18). A statistically significant enlargement emerged exclusively in pregnant women. The median (Interquartile Range) modification of the diameter of the lesions in cases and controls was +34% (+6%/+65%) and +2% (-6%/+12%), respectively (p<0.001). The median (Interquartile Range) modification of the volume of the lesions was +140% (+23%/+357%) and 0% (-18%/+37%), respectively (p<0.001). In pregnant women, we failed to document any significant correlation between the magnitude of the growth and ovarian responsiveness to hyper-stimulation, suggesting that steroids hormones are not the unique factors involved. In conclusion, fibroids undergo a rapid and remarkable growth during initial pregnancy. Reasons behind this phenomenon remain to be clarified. The early rise in steroids hormones during early pregnancy may not be sufficient to explain the process. Other pregnancy-related hormones and proteins may play also key roles.
format	article
author	Laura Benaglia Lucia Cardellicchio Francesca Filippi Alessio Paffoni Paolo Vercellini Edgardo Somigliana Luigi Fedele
author_facet	Laura Benaglia Lucia Cardellicchio Francesca Filippi Alessio Paffoni Paolo Vercellini Edgardo Somigliana Luigi Fedele
author_sort	Laura Benaglia
title	The rapid growth of fibroids during early pregnancy.
title_short	The rapid growth of fibroids during early pregnancy.
title_full	The rapid growth of fibroids during early pregnancy.
title_fullStr	The rapid growth of fibroids during early pregnancy.
title_full_unstemmed	The rapid growth of fibroids during early pregnancy.
title_sort	rapid growth of fibroids during early pregnancy.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/ee69162fd5d441e7bd19779e4114ab15
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The rapid growth of fibroids during early pregnancy.

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