SARS-CoV-2 infection in central North Carolina: Protocol for a population-based longitudinal cohort study and preliminary participant results.

Public health surveillance systems likely underestimate the true prevalence and incidence of SARS-CoV-2 infection due to limited access to testing and the high proportion of subclinical infections in community-based settings. This ongoing prospective, observational study aimed to generate accurate e...

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Autores principales:	Elyse M Miller, Elle A Law, Rawan Ajeen, Jaclyn Karasik, Carmen Mendoza, Haley Abernathy, Haley Garrett, Elise King, John Wallace, Michael Zelek, Jessie K Edwards, Khou Xiong, Cherese Beatty, Aaron T Fleischauer, Emily J Ciccone, Bonnie E Shook-Sa, Allison E Aiello, Ross M Boyce
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ee6a3236f679499aa26b218c56f17aab
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spelling	oai:doaj.org-article:ee6a3236f679499aa26b218c56f17aab2021-12-02T20:07:46ZSARS-CoV-2 infection in central North Carolina: Protocol for a population-based longitudinal cohort study and preliminary participant results.1932-620310.1371/journal.pone.0259070https://doaj.org/article/ee6a3236f679499aa26b218c56f17aab2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0259070https://doaj.org/toc/1932-6203Public health surveillance systems likely underestimate the true prevalence and incidence of SARS-CoV-2 infection due to limited access to testing and the high proportion of subclinical infections in community-based settings. This ongoing prospective, observational study aimed to generate accurate estimates of the prevalence and incidence of, and risk factors for, SARS-CoV-2 infection among residents of a central North Carolina county. From this cohort, we collected survey data and nasal swabs every two weeks and venous blood specimens every month. Nasal swabs were tested for the presence of SARS-CoV-2 virus (evidence of active infection), and serum specimens for SARS-CoV-2-specific antibodies (evidence of prior infection). As of June 23, 2021, we have enrolled a total of 153 participants from a county with an estimated 76,285 total residents. The anticipated study duration is at least 24 months, pending the evolution of the pandemic. Study data are being shared on a monthly basis with North Carolina state health authorities and future analyses aim to compare study data to state-wide metrics over time. Overall, the use of a probability-based sampling design and a well-characterized cohort will enable collection of critical data that can be used in planning and policy decisions for North Carolina and may be informative for other states with similar demographic characteristics.Elyse M MillerElle A LawRawan AjeenJaclyn KarasikCarmen MendozaHaley AbernathyHaley GarrettElise KingJohn WallaceMichael ZelekJessie K EdwardsKhou XiongCherese BeattyAaron T FleischauerEmily J CicconeBonnie E Shook-SaAllison E AielloRoss M BoycePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0259070 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elyse M Miller Elle A Law Rawan Ajeen Jaclyn Karasik Carmen Mendoza Haley Abernathy Haley Garrett Elise King John Wallace Michael Zelek Jessie K Edwards Khou Xiong Cherese Beatty Aaron T Fleischauer Emily J Ciccone Bonnie E Shook-Sa Allison E Aiello Ross M Boyce SARS-CoV-2 infection in central North Carolina: Protocol for a population-based longitudinal cohort study and preliminary participant results.
description	Public health surveillance systems likely underestimate the true prevalence and incidence of SARS-CoV-2 infection due to limited access to testing and the high proportion of subclinical infections in community-based settings. This ongoing prospective, observational study aimed to generate accurate estimates of the prevalence and incidence of, and risk factors for, SARS-CoV-2 infection among residents of a central North Carolina county. From this cohort, we collected survey data and nasal swabs every two weeks and venous blood specimens every month. Nasal swabs were tested for the presence of SARS-CoV-2 virus (evidence of active infection), and serum specimens for SARS-CoV-2-specific antibodies (evidence of prior infection). As of June 23, 2021, we have enrolled a total of 153 participants from a county with an estimated 76,285 total residents. The anticipated study duration is at least 24 months, pending the evolution of the pandemic. Study data are being shared on a monthly basis with North Carolina state health authorities and future analyses aim to compare study data to state-wide metrics over time. Overall, the use of a probability-based sampling design and a well-characterized cohort will enable collection of critical data that can be used in planning and policy decisions for North Carolina and may be informative for other states with similar demographic characteristics.
format	article
author	Elyse M Miller Elle A Law Rawan Ajeen Jaclyn Karasik Carmen Mendoza Haley Abernathy Haley Garrett Elise King John Wallace Michael Zelek Jessie K Edwards Khou Xiong Cherese Beatty Aaron T Fleischauer Emily J Ciccone Bonnie E Shook-Sa Allison E Aiello Ross M Boyce
author_facet	Elyse M Miller Elle A Law Rawan Ajeen Jaclyn Karasik Carmen Mendoza Haley Abernathy Haley Garrett Elise King John Wallace Michael Zelek Jessie K Edwards Khou Xiong Cherese Beatty Aaron T Fleischauer Emily J Ciccone Bonnie E Shook-Sa Allison E Aiello Ross M Boyce
author_sort	Elyse M Miller
title	SARS-CoV-2 infection in central North Carolina: Protocol for a population-based longitudinal cohort study and preliminary participant results.
title_short	SARS-CoV-2 infection in central North Carolina: Protocol for a population-based longitudinal cohort study and preliminary participant results.
title_full	SARS-CoV-2 infection in central North Carolina: Protocol for a population-based longitudinal cohort study and preliminary participant results.
title_fullStr	SARS-CoV-2 infection in central North Carolina: Protocol for a population-based longitudinal cohort study and preliminary participant results.
title_full_unstemmed	SARS-CoV-2 infection in central North Carolina: Protocol for a population-based longitudinal cohort study and preliminary participant results.
title_sort	sars-cov-2 infection in central north carolina: protocol for a population-based longitudinal cohort study and preliminary participant results.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/ee6a3236f679499aa26b218c56f17aab
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SARS-CoV-2 infection in central North Carolina: Protocol for a population-based longitudinal cohort study and preliminary participant results.

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