Potent inhibitors of toxic alpha-synuclein identified via cellular time-resolved FRET biosensors

Abstract We have developed a high-throughput drug discovery platform, measuring fluorescence resonance energy transfer (FRET) with fluorescent alpha-synuclein (αSN) biosensors, to detect spontaneous pre-fibrillar oligomers in living cells. Our two αSN FRET biosensors provide complementary insight in...

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Auteurs principaux:	Anthony R. Braun, Elly E. Liao, Mian Horvath, Prakriti Kalra, Karen Acosta, Malaney C. Young, Noah Nathan Kochen, Chih Hung Lo, Roland Brown, Michael D. Evans, William C. K. Pomerantz, Elizabeth Rhoades, Kelvin Luk, Razvan L. Cornea, David D. Thomas, Jonathan N. Sachs
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Neurology. Diseases of the nervous system RC346-429
Accès en ligne:	https://doaj.org/article/ee6b8563f73c49f68804418a48d07270
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Potent inhibitors of toxic alpha-synuclein identified via cellular time-resolved FRET biosensors

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