Potent inhibitors of toxic alpha-synuclein identified via cellular time-resolved FRET biosensors

Potent inhibitors of toxic alpha-synuclein identified via cellular time-resolved FRET biosensors

Abstract We have developed a high-throughput drug discovery platform, measuring fluorescence resonance energy transfer (FRET) with fluorescent alpha-synuclein (αSN) biosensors, to detect spontaneous pre-fibrillar oligomers in living cells. Our two αSN FRET biosensors provide complementary insight in...

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Bibliographic Details
Main Authors: Anthony R. Braun, Elly E. Liao, Mian Horvath, Prakriti Kalra, Karen Acosta, Malaney C. Young, Noah Nathan Kochen, Chih Hung Lo, Roland Brown, Michael D. Evans, William C. K. Pomerantz, Elizabeth Rhoades, Kelvin Luk, Razvan L. Cornea, David D. Thomas, Jonathan N. Sachs
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Neurology. Diseases of the nervous system
RC346-429
Online Access:https://doaj.org/article/ee6b8563f73c49f68804418a48d07270
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