Effects of tumor necrosis factor-β (TNF-β) 252A>G polymorphism on the development of migraine: a meta-analysis.

<h4>Background and objective</h4>Genetic factors including TNF-β have been considered as important components in the aetiology of migraine. Many studies have investigated the association between TNF-β 252A>G polymorphism and migraine risk, with debatable results. This study was design...

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Autores principales:	Ruozhuo Liu, Minghui Ma, Mingyu Cui, Zhao Dong, Xiaolin Wang, Wei Zhang, Minghui Yang, Shengyuan Yu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ee6c1350bf3b4c7b940e5cfd145f51f4
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spelling	oai:doaj.org-article:ee6c1350bf3b4c7b940e5cfd145f51f42021-11-11T08:21:49ZEffects of tumor necrosis factor-β (TNF-β) 252A>G polymorphism on the development of migraine: a meta-analysis.1932-620310.1371/journal.pone.0100189https://doaj.org/article/ee6c1350bf3b4c7b940e5cfd145f51f42014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24959879/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background and objective</h4>Genetic factors including TNF-β have been considered as important components in the aetiology of migraine. Many studies have investigated the association between TNF-β 252A>G polymorphism and migraine risk, with debatable results. This study was designed to examine whether the TNF-β 252A>G polymorphism confers genetic susceptibility to migraine in diverse populations.<h4>Method</h4>Studies eligible for this meta-analysis were searched in the PubMed, Embase, and CNKI by using the keywords "tumor necrosis factor", "TNF", "252A>G", "rs909253", "polymorphism", "polymorphisms", "variant", "SNP", combined with "migraine" or "migraine with aura (MA)" or "migraine without aura (MO)". Pooled ORs and 95% CI were appropriately calculated using the fixed-effect model.<h4>Results</h4>We finally included a total of seven studies, providing 5 557 migraineurs and 20 543 unrelated healthy controls. Meta-analysis results showed no statistical evidence of a significant association between TNF-β 252A>G polymorphism and overall migraine risk. Stratified analyses by type of migraine and gender revealed similar results. Interestingly, an OR with 95% CI representing an increased migraine risk was indicated in Asians under the recessive model (GG vs. AG + AA: OR, 1.38; 95%CI, 1.04-1.84; P for heterogeneity, 0.665).<h4>Conclusions</h4>Our findings appear to support the hypothesis that genetic variability of 252A>G polymorphism in TNF region may modulate risk of migraine in the population of Asian ancestry.Ruozhuo LiuMinghui MaMingyu CuiZhao DongXiaolin WangWei ZhangMinghui YangShengyuan YuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e100189 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ruozhuo Liu Minghui Ma Mingyu Cui Zhao Dong Xiaolin Wang Wei Zhang Minghui Yang Shengyuan Yu Effects of tumor necrosis factor-β (TNF-β) 252A>G polymorphism on the development of migraine: a meta-analysis.
description	<h4>Background and objective</h4>Genetic factors including TNF-β have been considered as important components in the aetiology of migraine. Many studies have investigated the association between TNF-β 252A>G polymorphism and migraine risk, with debatable results. This study was designed to examine whether the TNF-β 252A>G polymorphism confers genetic susceptibility to migraine in diverse populations.<h4>Method</h4>Studies eligible for this meta-analysis were searched in the PubMed, Embase, and CNKI by using the keywords "tumor necrosis factor", "TNF", "252A>G", "rs909253", "polymorphism", "polymorphisms", "variant", "SNP", combined with "migraine" or "migraine with aura (MA)" or "migraine without aura (MO)". Pooled ORs and 95% CI were appropriately calculated using the fixed-effect model.<h4>Results</h4>We finally included a total of seven studies, providing 5 557 migraineurs and 20 543 unrelated healthy controls. Meta-analysis results showed no statistical evidence of a significant association between TNF-β 252A>G polymorphism and overall migraine risk. Stratified analyses by type of migraine and gender revealed similar results. Interestingly, an OR with 95% CI representing an increased migraine risk was indicated in Asians under the recessive model (GG vs. AG + AA: OR, 1.38; 95%CI, 1.04-1.84; P for heterogeneity, 0.665).<h4>Conclusions</h4>Our findings appear to support the hypothesis that genetic variability of 252A>G polymorphism in TNF region may modulate risk of migraine in the population of Asian ancestry.
format	article
author	Ruozhuo Liu Minghui Ma Mingyu Cui Zhao Dong Xiaolin Wang Wei Zhang Minghui Yang Shengyuan Yu
author_facet	Ruozhuo Liu Minghui Ma Mingyu Cui Zhao Dong Xiaolin Wang Wei Zhang Minghui Yang Shengyuan Yu
author_sort	Ruozhuo Liu
title	Effects of tumor necrosis factor-β (TNF-β) 252A>G polymorphism on the development of migraine: a meta-analysis.
title_short	Effects of tumor necrosis factor-β (TNF-β) 252A>G polymorphism on the development of migraine: a meta-analysis.
title_full	Effects of tumor necrosis factor-β (TNF-β) 252A>G polymorphism on the development of migraine: a meta-analysis.
title_fullStr	Effects of tumor necrosis factor-β (TNF-β) 252A>G polymorphism on the development of migraine: a meta-analysis.
title_full_unstemmed	Effects of tumor necrosis factor-β (TNF-β) 252A>G polymorphism on the development of migraine: a meta-analysis.
title_sort	effects of tumor necrosis factor-β (tnf-β) 252a>g polymorphism on the development of migraine: a meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/ee6c1350bf3b4c7b940e5cfd145f51f4
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Effects of tumor necrosis factor-β (TNF-β) 252A>G polymorphism on the development of migraine: a meta-analysis.

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