Osteocrin ameliorates adriamycin nephropathy via p38 mitogen-activated protein kinase inhibition

Osteocrin ameliorates adriamycin nephropathy via p38 mitogen-activated protein kinase inhibition

Abstract Natriuretic peptides exert multiple effects by binding to natriuretic peptide receptors (NPRs). Osteocrin (OSTN) binds with high affinity to NPR-C, a clearance receptor for natriuretic peptides, and inhibits degradation of natriuretic peptides and consequently enhances guanylyl cyclase-A (G...

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Main Authors: Takaya Handa, Keita P. Mori, Akira Ishii, Shoko Ohno, Yugo Kanai, Haruko Watanabe-Takano, Akihiro Yasoda, Takashige Kuwabara, Nobuyuki Takahashi, Naoki Mochizuki, Masashi Mukoyama, Motoko Yanagita, Hideki Yokoi
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/ee6ea24a24204f86924bd4ac7c5ffbb8
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