Understanding fatigue in progressive supranuclear palsy

Abstract Fatigue is a common and disabling non-motor symptom (NMS) of Parkinson’s disease (PD); however, it has been poorly understood in patients with progressive supranuclear palsy (PSP). We investigated the association between fatigue, clinical features, and other NMS in patients with probable PS...

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Autores principales:	Jong Hyeon Ahn, Joomee Song, Dong Yeong Lee, Jinyoung Youn, Jin Whan Cho
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ee6f9c7322064933b5c2ff59677d35f7
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spelling	oai:doaj.org-article:ee6f9c7322064933b5c2ff59677d35f72021-12-02T17:08:44ZUnderstanding fatigue in progressive supranuclear palsy10.1038/s41598-021-96443-z2045-2322https://doaj.org/article/ee6f9c7322064933b5c2ff59677d35f72021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96443-zhttps://doaj.org/toc/2045-2322Abstract Fatigue is a common and disabling non-motor symptom (NMS) of Parkinson’s disease (PD); however, it has been poorly understood in patients with progressive supranuclear palsy (PSP). We investigated the association between fatigue, clinical features, and other NMS in patients with probable PSP. In 72 probable PSP patients, fatigue was investigated using the Parkinson Fatigue Scale (PFS). Further, all patients were evaluated using the PSP rating scale (PSPRS), Beck Depression Inventory (BDI), Mini-Mental State Examination (MMSE), Frontal Assessment Battery (FAB), PD Sleep Scale (PDSS), NMS scale (NMSS), PD Questionnaire-39 summary index (PDQ-39 SI), and Scale for outcomes in PD-Autonomic (SCOPA-AUT). The prevalence of fatigue assessed by PFS was 38.9% (28/72) in patients with PSP. The secondary fatigue was defined as fatigued patients with depression and/or sleep disturbances. We divided the patients into primary (n = 15), secondary (n = 13), and non-fatigue groups. There were no differences in age, sex, disease duration, and PSPRS, PDSS, MMSE, and FAB scores among the three groups. The primary fatigue group had higher scores in PDQ-39 SI compared to the non-fatigue group. The secondary fatigue group showed higher scores in NMSS, PDQ-39 SI, and SCOPA-AUT compared to the non-fatigue group. PFS was positively correlated with NMSS and PDQ-39 SI and SCOPA-AUT. Fatigue is common in patients with PSP and is associated with the NMS and the quality of life in these patients. The present study provides meaningful insight into fatigue in patients with PSP.Jong Hyeon AhnJoomee SongDong Yeong LeeJinyoung YounJin Whan ChoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jong Hyeon Ahn Joomee Song Dong Yeong Lee Jinyoung Youn Jin Whan Cho Understanding fatigue in progressive supranuclear palsy
description	Abstract Fatigue is a common and disabling non-motor symptom (NMS) of Parkinson’s disease (PD); however, it has been poorly understood in patients with progressive supranuclear palsy (PSP). We investigated the association between fatigue, clinical features, and other NMS in patients with probable PSP. In 72 probable PSP patients, fatigue was investigated using the Parkinson Fatigue Scale (PFS). Further, all patients were evaluated using the PSP rating scale (PSPRS), Beck Depression Inventory (BDI), Mini-Mental State Examination (MMSE), Frontal Assessment Battery (FAB), PD Sleep Scale (PDSS), NMS scale (NMSS), PD Questionnaire-39 summary index (PDQ-39 SI), and Scale for outcomes in PD-Autonomic (SCOPA-AUT). The prevalence of fatigue assessed by PFS was 38.9% (28/72) in patients with PSP. The secondary fatigue was defined as fatigued patients with depression and/or sleep disturbances. We divided the patients into primary (n = 15), secondary (n = 13), and non-fatigue groups. There were no differences in age, sex, disease duration, and PSPRS, PDSS, MMSE, and FAB scores among the three groups. The primary fatigue group had higher scores in PDQ-39 SI compared to the non-fatigue group. The secondary fatigue group showed higher scores in NMSS, PDQ-39 SI, and SCOPA-AUT compared to the non-fatigue group. PFS was positively correlated with NMSS and PDQ-39 SI and SCOPA-AUT. Fatigue is common in patients with PSP and is associated with the NMS and the quality of life in these patients. The present study provides meaningful insight into fatigue in patients with PSP.
format	article
author	Jong Hyeon Ahn Joomee Song Dong Yeong Lee Jinyoung Youn Jin Whan Cho
author_facet	Jong Hyeon Ahn Joomee Song Dong Yeong Lee Jinyoung Youn Jin Whan Cho
author_sort	Jong Hyeon Ahn
title	Understanding fatigue in progressive supranuclear palsy
title_short	Understanding fatigue in progressive supranuclear palsy
title_full	Understanding fatigue in progressive supranuclear palsy
title_fullStr	Understanding fatigue in progressive supranuclear palsy
title_full_unstemmed	Understanding fatigue in progressive supranuclear palsy
title_sort	understanding fatigue in progressive supranuclear palsy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ee6f9c7322064933b5c2ff59677d35f7
work_keys_str_mv	AT jonghyeonahn understandingfatigueinprogressivesupranuclearpalsy AT joomeesong understandingfatigueinprogressivesupranuclearpalsy AT dongyeonglee understandingfatigueinprogressivesupranuclearpalsy AT jinyoungyoun understandingfatigueinprogressivesupranuclearpalsy AT jinwhancho understandingfatigueinprogressivesupranuclearpalsy
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Understanding fatigue in progressive supranuclear palsy

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