RARα supports the development of Langerhans cells and langerin-expressing conventional dendritic cells

Langerhans cells (LC) and langerin-expressing conventional dendritic cells are made from distinct progenitors and enriched in the distinct microenvironments of the skin. Here the authors show that these immune cells are regulated by retinoic acid receptor alpha (RARα) via simultaneous induction of L...

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Autores principales:	Seika Hashimoto-Hill, Leon Friesen, Sungtae Park, Suji Im, Mark H. Kaplan, Chang H. Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ee73c86e5bb4416fa97b0ac484838d96
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spelling	oai:doaj.org-article:ee73c86e5bb4416fa97b0ac484838d962021-12-02T14:40:04ZRARα supports the development of Langerhans cells and langerin-expressing conventional dendritic cells10.1038/s41467-018-06341-82041-1723https://doaj.org/article/ee73c86e5bb4416fa97b0ac484838d962018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06341-8https://doaj.org/toc/2041-1723Langerhans cells (LC) and langerin-expressing conventional dendritic cells are made from distinct progenitors and enriched in the distinct microenvironments of the skin. Here the authors show that these immune cells are regulated by retinoic acid receptor alpha (RARα) via simultaneous induction of LC-promoting Runx3 and repression of LC-inhibiting C/EBPβ.Seika Hashimoto-HillLeon FriesenSungtae ParkSuji ImMark H. KaplanChang H. KimNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Seika Hashimoto-Hill Leon Friesen Sungtae Park Suji Im Mark H. Kaplan Chang H. Kim RARα supports the development of Langerhans cells and langerin-expressing conventional dendritic cells
description	Langerhans cells (LC) and langerin-expressing conventional dendritic cells are made from distinct progenitors and enriched in the distinct microenvironments of the skin. Here the authors show that these immune cells are regulated by retinoic acid receptor alpha (RARα) via simultaneous induction of LC-promoting Runx3 and repression of LC-inhibiting C/EBPβ.
format	article
author	Seika Hashimoto-Hill Leon Friesen Sungtae Park Suji Im Mark H. Kaplan Chang H. Kim
author_facet	Seika Hashimoto-Hill Leon Friesen Sungtae Park Suji Im Mark H. Kaplan Chang H. Kim
author_sort	Seika Hashimoto-Hill
title	RARα supports the development of Langerhans cells and langerin-expressing conventional dendritic cells
title_short	RARα supports the development of Langerhans cells and langerin-expressing conventional dendritic cells
title_full	RARα supports the development of Langerhans cells and langerin-expressing conventional dendritic cells
title_fullStr	RARα supports the development of Langerhans cells and langerin-expressing conventional dendritic cells
title_full_unstemmed	RARα supports the development of Langerhans cells and langerin-expressing conventional dendritic cells
title_sort	rarα supports the development of langerhans cells and langerin-expressing conventional dendritic cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ee73c86e5bb4416fa97b0ac484838d96
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RARα supports the development of Langerhans cells and langerin-expressing conventional dendritic cells

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