Incidence of diabetes mellitus and associated risk factors in the adult population of the Basque country, Spain

Abstract The aim of this study was to estimate the incidence of diabetes mellitus in the Basque Country and the risk factors involved in the disease by reassessing an adult population after 7 years of follow-up. In the previous prevalence study, 847 people older than 18 years were randomly selected...

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Autores principales:	Inés Urrutia, Alicia Martín-Nieto, Rosa Martínez, J Oriol Casanovas-Marsal, Anibal Aguayo, Juan del Olmo, Eunate Arana, Elsa Fernandez-Rubio, Luis Castaño, Sonia Gaztambide, The Diabetes Epidemiology Group
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ee747fc8f94b4c69b730816d1dda7ae4
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spelling	oai:doaj.org-article:ee747fc8f94b4c69b730816d1dda7ae42021-12-02T14:06:57ZIncidence of diabetes mellitus and associated risk factors in the adult population of the Basque country, Spain10.1038/s41598-021-82548-y2045-2322https://doaj.org/article/ee747fc8f94b4c69b730816d1dda7ae42021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82548-yhttps://doaj.org/toc/2045-2322Abstract The aim of this study was to estimate the incidence of diabetes mellitus in the Basque Country and the risk factors involved in the disease by reassessing an adult population after 7 years of follow-up. In the previous prevalence study, 847 people older than 18 years were randomly selected from all over the Basque Country and were invited to answer a medical questionnaire, followed by a physical examination and an oral glucose tolerance test. In the reassessment, the same variables were collected and the resulting cohort comprised 517 individuals of whom 43 had diabetes at baseline. The cumulative incidence of diabetes was 4.64% in 7 years and the raw incidence rate was 6.56 cases/1000 person-years (95%CI: 4.11–9.93). Among the incident cases, 59% were undiagnosed. The most strongly associated markers by univariate analyses were age > 60 years, dyslipidaemia, prediabetes and insulin resistance. We also found association with hypertension, obesity, family history of diabetes and low education level. Multivariate analysis adjusted for age and sex showed that a set of risk factors assessed together (dyslipidaemia, waist-to-hip-ratio and family history of diabetes) had great predictive value (AUC-ROC = 0.899, 95%CI: 0.846–0.953, p = 0.942), which suggests the need for early intervention before the onset of prediabetes.Inés UrrutiaAlicia Martín-NietoRosa MartínezJ Oriol Casanovas-MarsalAnibal AguayoJuan del OlmoEunate AranaElsa Fernandez-RubioLuis CastañoSonia GaztambideThe Diabetes Epidemiology GroupNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Inés Urrutia Alicia Martín-Nieto Rosa Martínez J Oriol Casanovas-Marsal Anibal Aguayo Juan del Olmo Eunate Arana Elsa Fernandez-Rubio Luis Castaño Sonia Gaztambide The Diabetes Epidemiology Group Incidence of diabetes mellitus and associated risk factors in the adult population of the Basque country, Spain
description	Abstract The aim of this study was to estimate the incidence of diabetes mellitus in the Basque Country and the risk factors involved in the disease by reassessing an adult population after 7 years of follow-up. In the previous prevalence study, 847 people older than 18 years were randomly selected from all over the Basque Country and were invited to answer a medical questionnaire, followed by a physical examination and an oral glucose tolerance test. In the reassessment, the same variables were collected and the resulting cohort comprised 517 individuals of whom 43 had diabetes at baseline. The cumulative incidence of diabetes was 4.64% in 7 years and the raw incidence rate was 6.56 cases/1000 person-years (95%CI: 4.11–9.93). Among the incident cases, 59% were undiagnosed. The most strongly associated markers by univariate analyses were age > 60 years, dyslipidaemia, prediabetes and insulin resistance. We also found association with hypertension, obesity, family history of diabetes and low education level. Multivariate analysis adjusted for age and sex showed that a set of risk factors assessed together (dyslipidaemia, waist-to-hip-ratio and family history of diabetes) had great predictive value (AUC-ROC = 0.899, 95%CI: 0.846–0.953, p = 0.942), which suggests the need for early intervention before the onset of prediabetes.
format	article
author	Inés Urrutia Alicia Martín-Nieto Rosa Martínez J Oriol Casanovas-Marsal Anibal Aguayo Juan del Olmo Eunate Arana Elsa Fernandez-Rubio Luis Castaño Sonia Gaztambide The Diabetes Epidemiology Group
author_facet	Inés Urrutia Alicia Martín-Nieto Rosa Martínez J Oriol Casanovas-Marsal Anibal Aguayo Juan del Olmo Eunate Arana Elsa Fernandez-Rubio Luis Castaño Sonia Gaztambide The Diabetes Epidemiology Group
author_sort	Inés Urrutia
title	Incidence of diabetes mellitus and associated risk factors in the adult population of the Basque country, Spain
title_short	Incidence of diabetes mellitus and associated risk factors in the adult population of the Basque country, Spain
title_full	Incidence of diabetes mellitus and associated risk factors in the adult population of the Basque country, Spain
title_fullStr	Incidence of diabetes mellitus and associated risk factors in the adult population of the Basque country, Spain
title_full_unstemmed	Incidence of diabetes mellitus and associated risk factors in the adult population of the Basque country, Spain
title_sort	incidence of diabetes mellitus and associated risk factors in the adult population of the basque country, spain
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ee747fc8f94b4c69b730816d1dda7ae4
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Incidence of diabetes mellitus and associated risk factors in the adult population of the Basque country, Spain

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