Design principles of collateral sensitivity-based dosing strategies

Collateral sensitivity-based antibiotic treatments may have the potential to limit the emergence of antimicrobial resistance. Here, the authors use mathematical modelling to study the effects of pathogen- and drug-specific characteristics for different treatment designs on bacterial population dynam...

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Auteurs principaux:	Linda B. S. Aulin, Apostolos Liakopoulos, Piet H. van der Graaf, Daniel E. Rozen, J. G. Coen van Hasselt
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/ee7918032aae4ee5bbcb1a37493613bc
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spelling	oai:doaj.org-article:ee7918032aae4ee5bbcb1a37493613bc2021-12-02T17:37:13ZDesign principles of collateral sensitivity-based dosing strategies10.1038/s41467-021-25927-32041-1723https://doaj.org/article/ee7918032aae4ee5bbcb1a37493613bc2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25927-3https://doaj.org/toc/2041-1723Collateral sensitivity-based antibiotic treatments may have the potential to limit the emergence of antimicrobial resistance. Here, the authors use mathematical modelling to study the effects of pathogen- and drug-specific characteristics for different treatment designs on bacterial population dynamics and resistance evolution.Linda B. S. AulinApostolos LiakopoulosPiet H. van der GraafDaniel E. RozenJ. G. Coen van HasseltNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Linda B. S. Aulin Apostolos Liakopoulos Piet H. van der Graaf Daniel E. Rozen J. G. Coen van Hasselt Design principles of collateral sensitivity-based dosing strategies
description	Collateral sensitivity-based antibiotic treatments may have the potential to limit the emergence of antimicrobial resistance. Here, the authors use mathematical modelling to study the effects of pathogen- and drug-specific characteristics for different treatment designs on bacterial population dynamics and resistance evolution.
format	article
author	Linda B. S. Aulin Apostolos Liakopoulos Piet H. van der Graaf Daniel E. Rozen J. G. Coen van Hasselt
author_facet	Linda B. S. Aulin Apostolos Liakopoulos Piet H. van der Graaf Daniel E. Rozen J. G. Coen van Hasselt
author_sort	Linda B. S. Aulin
title	Design principles of collateral sensitivity-based dosing strategies
title_short	Design principles of collateral sensitivity-based dosing strategies
title_full	Design principles of collateral sensitivity-based dosing strategies
title_fullStr	Design principles of collateral sensitivity-based dosing strategies
title_full_unstemmed	Design principles of collateral sensitivity-based dosing strategies
title_sort	design principles of collateral sensitivity-based dosing strategies
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ee7918032aae4ee5bbcb1a37493613bc
work_keys_str_mv	AT lindabsaulin designprinciplesofcollateralsensitivitybaseddosingstrategies AT apostolosliakopoulos designprinciplesofcollateralsensitivitybaseddosingstrategies AT piethvandergraaf designprinciplesofcollateralsensitivitybaseddosingstrategies AT danielerozen designprinciplesofcollateralsensitivitybaseddosingstrategies AT jgcoenvanhasselt designprinciplesofcollateralsensitivitybaseddosingstrategies
_version_	1718379916495421440

Design principles of collateral sensitivity-based dosing strategies

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