A family of unconventional deubiquitinases with modular chain specificity determinants

Deubiquitinating enzymes (DUBs) are essential to modulate ubiquitin signaling. While known DUBs can be grouped into six families, the authors here present biochemical and structural evidence for a seventh DUB family, defining determinants of substrate specificity for two representative enzymes.

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Autores principales:	Thomas Hermanns, Christian Pichlo, Ilka Woiwode, Karsten Klopffleisch, Katharina F. Witting, Huib Ovaa, Ulrich Baumann, Kay Hofmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ee7d765deef64ba6a8f81356743f0721
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spelling	oai:doaj.org-article:ee7d765deef64ba6a8f81356743f07212021-12-02T15:33:43ZA family of unconventional deubiquitinases with modular chain specificity determinants10.1038/s41467-018-03148-52041-1723https://doaj.org/article/ee7d765deef64ba6a8f81356743f07212018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03148-5https://doaj.org/toc/2041-1723Deubiquitinating enzymes (DUBs) are essential to modulate ubiquitin signaling. While known DUBs can be grouped into six families, the authors here present biochemical and structural evidence for a seventh DUB family, defining determinants of substrate specificity for two representative enzymes.Thomas HermannsChristian PichloIlka WoiwodeKarsten KlopffleischKatharina F. WittingHuib OvaaUlrich BaumannKay HofmannNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thomas Hermanns Christian Pichlo Ilka Woiwode Karsten Klopffleisch Katharina F. Witting Huib Ovaa Ulrich Baumann Kay Hofmann A family of unconventional deubiquitinases with modular chain specificity determinants
description	Deubiquitinating enzymes (DUBs) are essential to modulate ubiquitin signaling. While known DUBs can be grouped into six families, the authors here present biochemical and structural evidence for a seventh DUB family, defining determinants of substrate specificity for two representative enzymes.
format	article
author	Thomas Hermanns Christian Pichlo Ilka Woiwode Karsten Klopffleisch Katharina F. Witting Huib Ovaa Ulrich Baumann Kay Hofmann
author_facet	Thomas Hermanns Christian Pichlo Ilka Woiwode Karsten Klopffleisch Katharina F. Witting Huib Ovaa Ulrich Baumann Kay Hofmann
author_sort	Thomas Hermanns
title	A family of unconventional deubiquitinases with modular chain specificity determinants
title_short	A family of unconventional deubiquitinases with modular chain specificity determinants
title_full	A family of unconventional deubiquitinases with modular chain specificity determinants
title_fullStr	A family of unconventional deubiquitinases with modular chain specificity determinants
title_full_unstemmed	A family of unconventional deubiquitinases with modular chain specificity determinants
title_sort	family of unconventional deubiquitinases with modular chain specificity determinants
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ee7d765deef64ba6a8f81356743f0721
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A family of unconventional deubiquitinases with modular chain specificity determinants

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