GENETIC POLYMORPHISMS OF CD14, TNFα AND FCGR2A IN THE PATIENTS WITH INFLUENZA A H1N1 IN TRANSBAIKALIA REGION
Abstract. Relative frequencies of CD14 C-159T, TNFα G-308A and FCGR2A His166Arg genetic polymorphisms were studied in the patients with pandemic influenza A H1N1 in Transbaikalia Region. We have revealed that prevalences of allelic TNFα G-308A and CD14 C-159T variants were identical among...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | article |
| Language: | RU |
| Published: |
SPb RAACI
2014
|
| Subjects: | |
| Online Access: | https://doaj.org/article/ee7f80d245bf4416b0d738a0b90b8977 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Abstract. Relative frequencies of CD14 C-159T, TNFα G-308A and FCGR2A His166Arg genetic polymorphisms were studied in the patients with pandemic influenza A H1N1 in Transbaikalia Region. We have revealed that prevalences of allelic TNFα G-308A and CD14 C-159T variants were identical among the patients and in control group. With CD14 C-159T polymorphism, a C allele proved to be associated with severe and complicated clinical course of disease. The [CD14 (159СС); FCGR2A (166Arg/Arg)] haplotype regictered in two cases, was associated with fulminant course and fatal outcomes of the disease. (Med. Immunol., 2011, vol. 13, N 1, pp 83-86) |
|---|