GENETIC POLYMORPHISMS OF CD14, TNFα AND FCGR2A IN THE PATIENTS WITH INFLUENZA A H1N1 IN TRANSBAIKALIA REGION

Abstract. Relative frequencies of CD14 C-159T, TNFα G-308A and FCGR2A His166Arg genetic polymorphisms were studied in the patients with pandemic influenza A H1N1 in Transbaikalia Region. We have revealed that prevalences of allelic TNFα G-308A and CD14 C-159T variants were identical among...

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Autores principales:	V. V. Petrov, N. N. Strambovskaya, A. V. Govorin, Yu. A. Vitkovsky
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	keywords: cd14 tnfα fcgr2a gene polymorphism influenza а н1n1 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/ee7f80d245bf4416b0d738a0b90b8977
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spelling	oai:doaj.org-article:ee7f80d245bf4416b0d738a0b90b89772021-11-18T08:03:41ZGENETIC POLYMORPHISMS OF CD14, TNFα AND FCGR2A IN THE PATIENTS WITH INFLUENZA A H1N1 IN TRANSBAIKALIA REGION1563-06252313-741X10.15789/1563-0625-2011-1-83-86https://doaj.org/article/ee7f80d245bf4416b0d738a0b90b89772014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/403https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Relative frequencies of CD14 C-159T, TNFα G-308A and FCGR2A His166Arg genetic polymorphisms were studied in the patients with pandemic influenza A H1N1 in Transbaikalia Region. We have revealed that prevalences of allelic TNFα G-308A and CD14 C-159T variants were identical among the patients and in control group. With CD14 C-159T polymorphism, a C allele proved to be associated with severe and complicated clinical course of disease. The [CD14 (159СС); FCGR2A (166Arg/Arg)] haplotype regictered in two cases, was associated with fulminant course and fatal outcomes of the disease. (Med. Immunol., 2011, vol. 13, N 1, pp 83-86)V. V. PetrovN. N. StrambovskayaA. V. GovorinYu. A. VitkovskySPb RAACIarticlekeywords: cd14tnfαfcgr2agene polymorphisminfluenza а н1n1Immunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 1, Pp 83-86 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	keywords: cd14 tnfα fcgr2a gene polymorphism influenza а н1n1 Immunologic diseases. Allergy RC581-607
spellingShingle	keywords: cd14 tnfα fcgr2a gene polymorphism influenza а н1n1 Immunologic diseases. Allergy RC581-607 V. V. Petrov N. N. Strambovskaya A. V. Govorin Yu. A. Vitkovsky GENETIC POLYMORPHISMS OF CD14, TNFα AND FCGR2A IN THE PATIENTS WITH INFLUENZA A H1N1 IN TRANSBAIKALIA REGION
description	Abstract. Relative frequencies of CD14 C-159T, TNFα G-308A and FCGR2A His166Arg genetic polymorphisms were studied in the patients with pandemic influenza A H1N1 in Transbaikalia Region. We have revealed that prevalences of allelic TNFα G-308A and CD14 C-159T variants were identical among the patients and in control group. With CD14 C-159T polymorphism, a C allele proved to be associated with severe and complicated clinical course of disease. The [CD14 (159СС); FCGR2A (166Arg/Arg)] haplotype regictered in two cases, was associated with fulminant course and fatal outcomes of the disease. (Med. Immunol., 2011, vol. 13, N 1, pp 83-86)
format	article
author	V. V. Petrov N. N. Strambovskaya A. V. Govorin Yu. A. Vitkovsky
author_facet	V. V. Petrov N. N. Strambovskaya A. V. Govorin Yu. A. Vitkovsky
author_sort	V. V. Petrov
title	GENETIC POLYMORPHISMS OF CD14, TNFα AND FCGR2A IN THE PATIENTS WITH INFLUENZA A H1N1 IN TRANSBAIKALIA REGION
title_short	GENETIC POLYMORPHISMS OF CD14, TNFα AND FCGR2A IN THE PATIENTS WITH INFLUENZA A H1N1 IN TRANSBAIKALIA REGION
title_full	GENETIC POLYMORPHISMS OF CD14, TNFα AND FCGR2A IN THE PATIENTS WITH INFLUENZA A H1N1 IN TRANSBAIKALIA REGION
title_fullStr	GENETIC POLYMORPHISMS OF CD14, TNFα AND FCGR2A IN THE PATIENTS WITH INFLUENZA A H1N1 IN TRANSBAIKALIA REGION
title_full_unstemmed	GENETIC POLYMORPHISMS OF CD14, TNFα AND FCGR2A IN THE PATIENTS WITH INFLUENZA A H1N1 IN TRANSBAIKALIA REGION
title_sort	genetic polymorphisms of cd14, tnfα and fcgr2a in the patients with influenza a h1n1 in transbaikalia region
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/ee7f80d245bf4416b0d738a0b90b8977
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GENETIC POLYMORPHISMS OF CD14, TNFα AND FCGR2A IN THE PATIENTS WITH INFLUENZA A H1N1 IN TRANSBAIKALIA REGION

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