Issues with Intravitreal Administration of Anti-VEGF Drugs

Marc Schargus,1,2 Andreas Frings1,3 1Department of Ophthalmology, Heinrich Heine University, Duesseldorf, Germany; 2Department of Ophthalmology, Asklepios Hospital Nord-Heidberg, Hamburg, Germany; 3Augenarztpraxis Dr. Frings, Nuremberg, GermanyCorrespondence: Marc SchargusDepartment of Ophthalmology...

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Autores principales:	Schargus M, Frings A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	contamination intraocular pressure protein particles silicone oil syringes macular diseases Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/ee8212c44d6c45a1a1c529de79cc6ef3
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spelling	oai:doaj.org-article:ee8212c44d6c45a1a1c529de79cc6ef32021-12-02T15:29:52ZIssues with Intravitreal Administration of Anti-VEGF Drugs1177-5483https://doaj.org/article/ee8212c44d6c45a1a1c529de79cc6ef32020-03-01T00:00:00Zhttps://www.dovepress.com/issues-with-intravitreal-administration-of-anti-vegf-drugs-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Marc Schargus,1,2 Andreas Frings1,3 1Department of Ophthalmology, Heinrich Heine University, Duesseldorf, Germany; 2Department of Ophthalmology, Asklepios Hospital Nord-Heidberg, Hamburg, Germany; 3Augenarztpraxis Dr. Frings, Nuremberg, GermanyCorrespondence: Marc SchargusDepartment of Ophthalmology, Heinrich-Heine-University Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, GermanyTel +49-177-6272724Email marc.schargus@gmx.dePurpose: To provide an update of summary of risk factors and side effects of long-term use and contamination of intravitreal anti-VEGF injections.Methods: We reviewed relevant publications of the topic of contamination of anti-VEGF injections and long-term side effects due to this reason.Results: Due to the long-term use of anti-VEGF drugs and the higher number of injections worldwide, various studies have shown side effects in recent years, ranging from increased intraocular pressure to visual disturbing silicone oil vesicles in the vitreous cavity. Several studies have demonstrated that both the drug and the processing, storage, environmental factors and the material and design of the syringes have a decisive influence on these side effects.Conclusion: The risks of deposits from syringes in the eye can be significantly reduced by various optimizations in transport, storage and syringe and cannula selection.Keywords: contamination, intraocular pressure, protein particles, silicone oil, syringes, macular diseasesSchargus MFrings ADove Medical Pressarticlecontaminationintraocular pressureprotein particlessilicone oilsyringesmacular diseasesOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 897-904 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	contamination intraocular pressure protein particles silicone oil syringes macular diseases Ophthalmology RE1-994
spellingShingle	contamination intraocular pressure protein particles silicone oil syringes macular diseases Ophthalmology RE1-994 Schargus M Frings A Issues with Intravitreal Administration of Anti-VEGF Drugs
description	Marc Schargus,1,2 Andreas Frings1,3 1Department of Ophthalmology, Heinrich Heine University, Duesseldorf, Germany; 2Department of Ophthalmology, Asklepios Hospital Nord-Heidberg, Hamburg, Germany; 3Augenarztpraxis Dr. Frings, Nuremberg, GermanyCorrespondence: Marc SchargusDepartment of Ophthalmology, Heinrich-Heine-University Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, GermanyTel +49-177-6272724Email marc.schargus@gmx.dePurpose: To provide an update of summary of risk factors and side effects of long-term use and contamination of intravitreal anti-VEGF injections.Methods: We reviewed relevant publications of the topic of contamination of anti-VEGF injections and long-term side effects due to this reason.Results: Due to the long-term use of anti-VEGF drugs and the higher number of injections worldwide, various studies have shown side effects in recent years, ranging from increased intraocular pressure to visual disturbing silicone oil vesicles in the vitreous cavity. Several studies have demonstrated that both the drug and the processing, storage, environmental factors and the material and design of the syringes have a decisive influence on these side effects.Conclusion: The risks of deposits from syringes in the eye can be significantly reduced by various optimizations in transport, storage and syringe and cannula selection.Keywords: contamination, intraocular pressure, protein particles, silicone oil, syringes, macular diseases
format	article
author	Schargus M Frings A
author_facet	Schargus M Frings A
author_sort	Schargus M
title	Issues with Intravitreal Administration of Anti-VEGF Drugs
title_short	Issues with Intravitreal Administration of Anti-VEGF Drugs
title_full	Issues with Intravitreal Administration of Anti-VEGF Drugs
title_fullStr	Issues with Intravitreal Administration of Anti-VEGF Drugs
title_full_unstemmed	Issues with Intravitreal Administration of Anti-VEGF Drugs
title_sort	issues with intravitreal administration of anti-vegf drugs
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/ee8212c44d6c45a1a1c529de79cc6ef3
work_keys_str_mv	AT schargusm issueswithintravitrealadministrationofantivegfdrugs AT fringsa issueswithintravitrealadministrationofantivegfdrugs
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Issues with Intravitreal Administration of Anti-VEGF Drugs

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