Inflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers

Preeclampsia is both a vascular and inflammatory disorder. Since the placenta is a conduit for fetal development, preeclampsia should be a presumed cause of adverse infant outcomes. Yet, the relationship of placental pathology, inflammation and neurological outcomes after preeclampsia are understudi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alexandra Sotiros, Dianne Thornhill, Miriam D. Post, Virginia D. Winn, Jennifer Armstrong
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ee8649ec665345b59a9aea6cb1c43e03
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ee8649ec665345b59a9aea6cb1c43e03
record_format	dspace
spelling	oai:doaj.org-article:ee8649ec665345b59a9aea6cb1c43e032021-11-25T05:54:26ZInflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers1932-6203https://doaj.org/article/ee8649ec665345b59a9aea6cb1c43e032021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592443/?tool=EBIhttps://doaj.org/toc/1932-6203Preeclampsia is both a vascular and inflammatory disorder. Since the placenta is a conduit for fetal development, preeclampsia should be a presumed cause of adverse infant outcomes. Yet, the relationship of placental pathology, inflammation and neurological outcomes after preeclampsia are understudied. We prospectively examined a cohort of maternal-infant dyads with preeclampsia for maternal inflammatory cytokines at time of preeclampsia diagnosis and delivery, and fetal cord blood cytokines (IL-1β, IL-6, IL-8, and TNF-α). Placentas were analyzed for inflammatory and vascular pathologies. Neurodevelopmental assessment of infants utilizing the Pediatric Stroke Outcome Measure (PSOM) was conducted at 6-month corrected gestational age. Eighty-one maternal-newborn dyads were examined. Worse neurological outcomes were not associated with elevated maternal / fetal cytokines. Early preterm birth (gestational age ≤ 32 weeks) was associated with worse neurological outcomes at 6-months regardless of maternal/ fetal cytokine levels, placental pathology, or cranial ultrasound findings (OR 1.70, [1.16–2.48], p = 0.006). When correcting for gestational age, elevated IL-6 approached significance as a predictor for worse developmental outcome (OR 1.025 [0.985–1.066], p = 0.221). Pathological evidence of maternal malperfusion and worse outcomes were noted in early preterm, although our sample size was small. Our study did not demonstrate an obvious association of inflammation and placental pathology in preeclampsia and adverse neurodevelopmental outcome at 6-month corrected age but does suggest maternal malperfusion at earlier gestational age may be a risk factor for worse outcome.Alexandra SotirosDianne ThornhillMiriam D. PostVirginia D. WinnJennifer ArmstrongPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alexandra Sotiros Dianne Thornhill Miriam D. Post Virginia D. Winn Jennifer Armstrong Inflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers
description	Preeclampsia is both a vascular and inflammatory disorder. Since the placenta is a conduit for fetal development, preeclampsia should be a presumed cause of adverse infant outcomes. Yet, the relationship of placental pathology, inflammation and neurological outcomes after preeclampsia are understudied. We prospectively examined a cohort of maternal-infant dyads with preeclampsia for maternal inflammatory cytokines at time of preeclampsia diagnosis and delivery, and fetal cord blood cytokines (IL-1β, IL-6, IL-8, and TNF-α). Placentas were analyzed for inflammatory and vascular pathologies. Neurodevelopmental assessment of infants utilizing the Pediatric Stroke Outcome Measure (PSOM) was conducted at 6-month corrected gestational age. Eighty-one maternal-newborn dyads were examined. Worse neurological outcomes were not associated with elevated maternal / fetal cytokines. Early preterm birth (gestational age ≤ 32 weeks) was associated with worse neurological outcomes at 6-months regardless of maternal/ fetal cytokine levels, placental pathology, or cranial ultrasound findings (OR 1.70, [1.16–2.48], p = 0.006). When correcting for gestational age, elevated IL-6 approached significance as a predictor for worse developmental outcome (OR 1.025 [0.985–1.066], p = 0.221). Pathological evidence of maternal malperfusion and worse outcomes were noted in early preterm, although our sample size was small. Our study did not demonstrate an obvious association of inflammation and placental pathology in preeclampsia and adverse neurodevelopmental outcome at 6-month corrected age but does suggest maternal malperfusion at earlier gestational age may be a risk factor for worse outcome.
format	article
author	Alexandra Sotiros Dianne Thornhill Miriam D. Post Virginia D. Winn Jennifer Armstrong
author_facet	Alexandra Sotiros Dianne Thornhill Miriam D. Post Virginia D. Winn Jennifer Armstrong
author_sort	Alexandra Sotiros
title	Inflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers
title_short	Inflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers
title_full	Inflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers
title_fullStr	Inflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers
title_full_unstemmed	Inflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers
title_sort	inflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/ee8649ec665345b59a9aea6cb1c43e03
work_keys_str_mv	AT alexandrasotiros inflammatorycytokinesplacentalpathologyandneurologicaloutcomesininfantsborntopretermpreeclampticmothers AT diannethornhill inflammatorycytokinesplacentalpathologyandneurologicaloutcomesininfantsborntopretermpreeclampticmothers AT miriamdpost inflammatorycytokinesplacentalpathologyandneurologicaloutcomesininfantsborntopretermpreeclampticmothers AT virginiadwinn inflammatorycytokinesplacentalpathologyandneurologicaloutcomesininfantsborntopretermpreeclampticmothers AT jenniferarmstrong inflammatorycytokinesplacentalpathologyandneurologicaloutcomesininfantsborntopretermpreeclampticmothers
_version_	1718414435054256128

Inflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers

Ejemplares similares