UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation

Hyperphosphorylated Tau accumulation promotes neurodegeneration in Alzheimer’s disease. Here, the authors screen a miRNA library in Drosophila and identify a conserved ubiquitin ligase that directs Tau for autophagic degradation, uncovering a potential target to treat Tau-mediated neurodegeneration....

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Autores principales:	Manivannan Subramanian, Seung Jae Hyeon, Tanuza Das, Yoon Seok Suh, Yun Kyung Kim, Jeong-Soo Lee, Eun Joo Song, Hoon Ryu, Kweon Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ee8a7f6a151f4e33bd0f9accda17a866
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spelling	oai:doaj.org-article:ee8a7f6a151f4e33bd0f9accda17a8662021-12-02T17:51:19ZUBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation10.1038/s41467-021-23597-92041-1723https://doaj.org/article/ee8a7f6a151f4e33bd0f9accda17a8662021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23597-9https://doaj.org/toc/2041-1723Hyperphosphorylated Tau accumulation promotes neurodegeneration in Alzheimer’s disease. Here, the authors screen a miRNA library in Drosophila and identify a conserved ubiquitin ligase that directs Tau for autophagic degradation, uncovering a potential target to treat Tau-mediated neurodegeneration.Manivannan SubramanianSeung Jae HyeonTanuza DasYoon Seok SuhYun Kyung KimJeong-Soo LeeEun Joo SongHoon RyuKweon YuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Manivannan Subramanian Seung Jae Hyeon Tanuza Das Yoon Seok Suh Yun Kyung Kim Jeong-Soo Lee Eun Joo Song Hoon Ryu Kweon Yu UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation
description	Hyperphosphorylated Tau accumulation promotes neurodegeneration in Alzheimer’s disease. Here, the authors screen a miRNA library in Drosophila and identify a conserved ubiquitin ligase that directs Tau for autophagic degradation, uncovering a potential target to treat Tau-mediated neurodegeneration.
format	article
author	Manivannan Subramanian Seung Jae Hyeon Tanuza Das Yoon Seok Suh Yun Kyung Kim Jeong-Soo Lee Eun Joo Song Hoon Ryu Kweon Yu
author_facet	Manivannan Subramanian Seung Jae Hyeon Tanuza Das Yoon Seok Suh Yun Kyung Kim Jeong-Soo Lee Eun Joo Song Hoon Ryu Kweon Yu
author_sort	Manivannan Subramanian
title	UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation
title_short	UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation
title_full	UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation
title_fullStr	UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation
title_full_unstemmed	UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation
title_sort	ube4b, a microrna-9 target gene, promotes autophagy-mediated tau degradation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ee8a7f6a151f4e33bd0f9accda17a866
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UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation

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