Widespread attenuating changes in brain connectivity associated with the general factor of psychopathology in 9- and 10-year olds

Abstract Convergent research identifies a general factor (“P factor”) that confers transdiagnostic risk for psychopathology. Large-scale networks are key organizational units of the human brain. However, studies of altered network connectivity patterns associated with the P factor are limited, espec...

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Autores principales:	Chandra Sripada, Mike Angstadt, Aman Taxali, Daniel Kessler, Tristan Greathouse, Saige Rutherford, D. Angus Clark, Luke W. Hyde, Alex Weigard, Sarah J. Brislin, Brian Hicks, Mary Heitzeg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/ee8cd0f40693439696ddc38b551fb466
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spelling	oai:doaj.org-article:ee8cd0f40693439696ddc38b551fb4662021-11-14T12:11:29ZWidespread attenuating changes in brain connectivity associated with the general factor of psychopathology in 9- and 10-year olds10.1038/s41398-021-01708-w2158-3188https://doaj.org/article/ee8cd0f40693439696ddc38b551fb4662021-11-01T00:00:00Zhttps://doi.org/10.1038/s41398-021-01708-whttps://doaj.org/toc/2158-3188Abstract Convergent research identifies a general factor (“P factor”) that confers transdiagnostic risk for psychopathology. Large-scale networks are key organizational units of the human brain. However, studies of altered network connectivity patterns associated with the P factor are limited, especially in early adolescence when most mental disorders are first emerging. We studied 11,875 9- and 10-year olds from the Adolescent Brain and Cognitive Development (ABCD) study, of whom 6593 had high-quality resting-state scans. Network contingency analysis was used to identify altered interconnections associated with the P factor among 16 large-scale networks. These connectivity changes were then further characterized with quadrant analysis that quantified the directionality of P factor effects in relation to neurotypical patterns of positive versus negative connectivity across connections. The results showed that the P factor was associated with altered connectivity across 28 network cells (i.e., sets of connections linking pairs of networks); p PERMUTATION values < 0.05 FDR-corrected for multiple comparisons. Higher P factor scores were associated with hypoconnectivity within default network and hyperconnectivity between default network and multiple control networks. Among connections within these 28 significant cells, the P factor was predominantly associated with “attenuating” effects (67%; p PERMUTATION < 0.0002), i.e., reduced connectivity at neurotypically positive connections and increased connectivity at neurotypically negative connections. These results demonstrate that the general factor of psychopathology produces attenuating changes across multiple networks including default network, involved in spontaneous responses, and control networks involved in cognitive control. Moreover, they clarify mechanisms of transdiagnostic risk for psychopathology and invite further research into developmental causes of distributed attenuated connectivity.Chandra SripadaMike AngstadtAman TaxaliDaniel KesslerTristan GreathouseSaige RutherfordD. Angus ClarkLuke W. HydeAlex WeigardSarah J. BrislinBrian HicksMary HeitzegNature Publishing GrouparticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Psychiatry, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Chandra Sripada Mike Angstadt Aman Taxali Daniel Kessler Tristan Greathouse Saige Rutherford D. Angus Clark Luke W. Hyde Alex Weigard Sarah J. Brislin Brian Hicks Mary Heitzeg Widespread attenuating changes in brain connectivity associated with the general factor of psychopathology in 9- and 10-year olds
description	Abstract Convergent research identifies a general factor (“P factor”) that confers transdiagnostic risk for psychopathology. Large-scale networks are key organizational units of the human brain. However, studies of altered network connectivity patterns associated with the P factor are limited, especially in early adolescence when most mental disorders are first emerging. We studied 11,875 9- and 10-year olds from the Adolescent Brain and Cognitive Development (ABCD) study, of whom 6593 had high-quality resting-state scans. Network contingency analysis was used to identify altered interconnections associated with the P factor among 16 large-scale networks. These connectivity changes were then further characterized with quadrant analysis that quantified the directionality of P factor effects in relation to neurotypical patterns of positive versus negative connectivity across connections. The results showed that the P factor was associated with altered connectivity across 28 network cells (i.e., sets of connections linking pairs of networks); p PERMUTATION values < 0.05 FDR-corrected for multiple comparisons. Higher P factor scores were associated with hypoconnectivity within default network and hyperconnectivity between default network and multiple control networks. Among connections within these 28 significant cells, the P factor was predominantly associated with “attenuating” effects (67%; p PERMUTATION < 0.0002), i.e., reduced connectivity at neurotypically positive connections and increased connectivity at neurotypically negative connections. These results demonstrate that the general factor of psychopathology produces attenuating changes across multiple networks including default network, involved in spontaneous responses, and control networks involved in cognitive control. Moreover, they clarify mechanisms of transdiagnostic risk for psychopathology and invite further research into developmental causes of distributed attenuated connectivity.
format	article
author	Chandra Sripada Mike Angstadt Aman Taxali Daniel Kessler Tristan Greathouse Saige Rutherford D. Angus Clark Luke W. Hyde Alex Weigard Sarah J. Brislin Brian Hicks Mary Heitzeg
author_facet	Chandra Sripada Mike Angstadt Aman Taxali Daniel Kessler Tristan Greathouse Saige Rutherford D. Angus Clark Luke W. Hyde Alex Weigard Sarah J. Brislin Brian Hicks Mary Heitzeg
author_sort	Chandra Sripada
title	Widespread attenuating changes in brain connectivity associated with the general factor of psychopathology in 9- and 10-year olds
title_short	Widespread attenuating changes in brain connectivity associated with the general factor of psychopathology in 9- and 10-year olds
title_full	Widespread attenuating changes in brain connectivity associated with the general factor of psychopathology in 9- and 10-year olds
title_fullStr	Widespread attenuating changes in brain connectivity associated with the general factor of psychopathology in 9- and 10-year olds
title_full_unstemmed	Widespread attenuating changes in brain connectivity associated with the general factor of psychopathology in 9- and 10-year olds
title_sort	widespread attenuating changes in brain connectivity associated with the general factor of psychopathology in 9- and 10-year olds
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/ee8cd0f40693439696ddc38b551fb466
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Widespread attenuating changes in brain connectivity associated with the general factor of psychopathology in 9- and 10-year olds

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