Visit-to-visit Variability of Blood Pressure and Risk of Stroke: Results of the Kailuan Cohort Study

Abstract Uncertainty persists regarding the need to address blood pressure (BP) variability in the general population to reduce the heavy burden of stroke. In this cohort study, we prospectively recruited 57,927 participants from southeast of Beijing, who have completed all 3 health examinations bet...

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Autores principales:	Haijiang Dai, Yao Lu, Lu Song, Xiaohong Tang, Ying Li, Ruifang Chen, Aijing Luo, Hong Yuan, Shouling Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ee8ce5024b574138b45c6fd2c45deea9
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spelling	oai:doaj.org-article:ee8ce5024b574138b45c6fd2c45deea92021-12-02T15:05:19ZVisit-to-visit Variability of Blood Pressure and Risk of Stroke: Results of the Kailuan Cohort Study10.1038/s41598-017-00380-92045-2322https://doaj.org/article/ee8ce5024b574138b45c6fd2c45deea92017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00380-9https://doaj.org/toc/2045-2322Abstract Uncertainty persists regarding the need to address blood pressure (BP) variability in the general population to reduce the heavy burden of stroke. In this cohort study, we prospectively recruited 57,927 participants from southeast of Beijing, who have completed all 3 health examinations between 2006 and 2010. BP variability was defined as the coefficient of variation (CV) across these 3 visits. Over a median follow-up of 3.0 years, we identified 582 first stroke cases. Of these, 489 (84.0%) were ischemic strokes and 94 (16.2%) were hemorrhagic strokes. After multivariable adjustment, the hazard ratios (HR) (95% Confidence Intervals, CI) of comparing participants in the highest versus lowest quartile of CV of systolic blood pressure (SBP) was 1.44 (1.11, 1.87) for any stroke, 1.33 (1.00, 1.77) for ischemic stroke, and 2.17 (1.09, 4.35) for hemorrhagic stroke. Similar results were also observed when the CV of SBP was considered as a continuous exposure variable (per SD increase). Moreover, higher variability of diastolic blood pressure (DBP) was also significantly associated with the risk of any stroke and specifically with hemorrhagic stroke, but not with ischemic stroke. In conclusion, higher visit-to-visit BP variability might be an important target to reduce stroke risk, particularly for hemorrhagic stroke.Haijiang DaiYao LuLu SongXiaohong TangYing LiRuifang ChenAijing LuoHong YuanShouling WuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Haijiang Dai Yao Lu Lu Song Xiaohong Tang Ying Li Ruifang Chen Aijing Luo Hong Yuan Shouling Wu Visit-to-visit Variability of Blood Pressure and Risk of Stroke: Results of the Kailuan Cohort Study
description	Abstract Uncertainty persists regarding the need to address blood pressure (BP) variability in the general population to reduce the heavy burden of stroke. In this cohort study, we prospectively recruited 57,927 participants from southeast of Beijing, who have completed all 3 health examinations between 2006 and 2010. BP variability was defined as the coefficient of variation (CV) across these 3 visits. Over a median follow-up of 3.0 years, we identified 582 first stroke cases. Of these, 489 (84.0%) were ischemic strokes and 94 (16.2%) were hemorrhagic strokes. After multivariable adjustment, the hazard ratios (HR) (95% Confidence Intervals, CI) of comparing participants in the highest versus lowest quartile of CV of systolic blood pressure (SBP) was 1.44 (1.11, 1.87) for any stroke, 1.33 (1.00, 1.77) for ischemic stroke, and 2.17 (1.09, 4.35) for hemorrhagic stroke. Similar results were also observed when the CV of SBP was considered as a continuous exposure variable (per SD increase). Moreover, higher variability of diastolic blood pressure (DBP) was also significantly associated with the risk of any stroke and specifically with hemorrhagic stroke, but not with ischemic stroke. In conclusion, higher visit-to-visit BP variability might be an important target to reduce stroke risk, particularly for hemorrhagic stroke.
format	article
author	Haijiang Dai Yao Lu Lu Song Xiaohong Tang Ying Li Ruifang Chen Aijing Luo Hong Yuan Shouling Wu
author_facet	Haijiang Dai Yao Lu Lu Song Xiaohong Tang Ying Li Ruifang Chen Aijing Luo Hong Yuan Shouling Wu
author_sort	Haijiang Dai
title	Visit-to-visit Variability of Blood Pressure and Risk of Stroke: Results of the Kailuan Cohort Study
title_short	Visit-to-visit Variability of Blood Pressure and Risk of Stroke: Results of the Kailuan Cohort Study
title_full	Visit-to-visit Variability of Blood Pressure and Risk of Stroke: Results of the Kailuan Cohort Study
title_fullStr	Visit-to-visit Variability of Blood Pressure and Risk of Stroke: Results of the Kailuan Cohort Study
title_full_unstemmed	Visit-to-visit Variability of Blood Pressure and Risk of Stroke: Results of the Kailuan Cohort Study
title_sort	visit-to-visit variability of blood pressure and risk of stroke: results of the kailuan cohort study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ee8ce5024b574138b45c6fd2c45deea9
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Visit-to-visit Variability of Blood Pressure and Risk of Stroke: Results of the Kailuan Cohort Study

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