Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation

A chromatin remodelling factor Satb1 is essential for T cell lineage development in the thymus. Here the authors show that while Satb1 is dispensable for the differentiation of Th17 cells and their response to gut commensals, it plays a critical role in pathogenic Th17 effector function in EAE by di...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Keiko Yasuda, Yohko Kitagawa, Ryoji Kawakami, Yoshitaka Isaka, Hitomi Watanabe, Gen Kondoh, Terumi Kohwi-Shigematsu, Shimon Sakaguchi, Keiji Hirota
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ee8dcdc2a13e4bc2b13dd9a6f3c601fd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ee8dcdc2a13e4bc2b13dd9a6f3c601fd
record_format	dspace
spelling	oai:doaj.org-article:ee8dcdc2a13e4bc2b13dd9a6f3c601fd2021-12-02T17:32:40ZSatb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation10.1038/s41467-019-08404-w2041-1723https://doaj.org/article/ee8dcdc2a13e4bc2b13dd9a6f3c601fd2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08404-whttps://doaj.org/toc/2041-1723A chromatin remodelling factor Satb1 is essential for T cell lineage development in the thymus. Here the authors show that while Satb1 is dispensable for the differentiation of Th17 cells and their response to gut commensals, it plays a critical role in pathogenic Th17 effector function in EAE by directly activating Bhlhe40 and modulating PD-1.Keiko YasudaYohko KitagawaRyoji KawakamiYoshitaka IsakaHitomi WatanabeGen KondohTerumi Kohwi-ShigematsuShimon SakaguchiKeiji HirotaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Keiko Yasuda Yohko Kitagawa Ryoji Kawakami Yoshitaka Isaka Hitomi Watanabe Gen Kondoh Terumi Kohwi-Shigematsu Shimon Sakaguchi Keiji Hirota Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation
description	A chromatin remodelling factor Satb1 is essential for T cell lineage development in the thymus. Here the authors show that while Satb1 is dispensable for the differentiation of Th17 cells and their response to gut commensals, it plays a critical role in pathogenic Th17 effector function in EAE by directly activating Bhlhe40 and modulating PD-1.
format	article
author	Keiko Yasuda Yohko Kitagawa Ryoji Kawakami Yoshitaka Isaka Hitomi Watanabe Gen Kondoh Terumi Kohwi-Shigematsu Shimon Sakaguchi Keiji Hirota
author_facet	Keiko Yasuda Yohko Kitagawa Ryoji Kawakami Yoshitaka Isaka Hitomi Watanabe Gen Kondoh Terumi Kohwi-Shigematsu Shimon Sakaguchi Keiji Hirota
author_sort	Keiko Yasuda
title	Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation
title_short	Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation
title_full	Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation
title_fullStr	Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation
title_full_unstemmed	Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation
title_sort	satb1 regulates the effector program of encephalitogenic tissue th17 cells in chronic inflammation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ee8dcdc2a13e4bc2b13dd9a6f3c601fd
work_keys_str_mv	AT keikoyasuda satb1regulatestheeffectorprogramofencephalitogenictissueth17cellsinchronicinflammation AT yohkokitagawa satb1regulatestheeffectorprogramofencephalitogenictissueth17cellsinchronicinflammation AT ryojikawakami satb1regulatestheeffectorprogramofencephalitogenictissueth17cellsinchronicinflammation AT yoshitakaisaka satb1regulatestheeffectorprogramofencephalitogenictissueth17cellsinchronicinflammation AT hitomiwatanabe satb1regulatestheeffectorprogramofencephalitogenictissueth17cellsinchronicinflammation AT genkondoh satb1regulatestheeffectorprogramofencephalitogenictissueth17cellsinchronicinflammation AT terumikohwishigematsu satb1regulatestheeffectorprogramofencephalitogenictissueth17cellsinchronicinflammation AT shimonsakaguchi satb1regulatestheeffectorprogramofencephalitogenictissueth17cellsinchronicinflammation AT keijihirota satb1regulatestheeffectorprogramofencephalitogenictissueth17cellsinchronicinflammation
_version_	1718380220485992448

Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation

Ejemplares similares