High degree of heterogeneity in Alzheimer's disease progression patterns.

There have been several reports on the varying rates of progression among Alzheimer's Disease (AD) patients; however, there has been no quantitative study of the amount of heterogeneity in AD. Obtaining a reliable quantitative measure of AD progression rates and their variances among the patien...

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Autores principales:	Natalia L Komarova, Craig J Thalhauser
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ee8f51759d4c43a1b7b743d170433e8a
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spelling	oai:doaj.org-article:ee8f51759d4c43a1b7b743d170433e8a2021-11-18T05:51:49ZHigh degree of heterogeneity in Alzheimer's disease progression patterns.1553-734X1553-735810.1371/journal.pcbi.1002251https://doaj.org/article/ee8f51759d4c43a1b7b743d170433e8a2011-11-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22072952/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358There have been several reports on the varying rates of progression among Alzheimer's Disease (AD) patients; however, there has been no quantitative study of the amount of heterogeneity in AD. Obtaining a reliable quantitative measure of AD progression rates and their variances among the patients for each stage of AD is essential for evaluating results of any clinical study. The Global Deterioration Scale (GDS) and Functional Assessment Staging procedure (FAST) characterize seven stages in the course of AD from normal aging to severe dementia. Each GDS/FAST stage has a published mean duration, but the variance is unknown. We use statistical analysis to reconstruct GDS/FAST stage durations in a cohort of 648 AD patients with an average follow-up time of 4.78 years. Calculations for GDS/FAST stages 4-6 reveal that the standard deviations for stage durations are comparable with their mean values, indicating the presence of large variations in the AD progression among patients. Such amount of heterogeneity in the course of progression of AD is consistent with the existence of several sub-groups of AD patients, which differ by their patterns of decline.Natalia L KomarovaCraig J ThalhauserPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 7, Iss 11, p e1002251 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Natalia L Komarova Craig J Thalhauser High degree of heterogeneity in Alzheimer's disease progression patterns.
description	There have been several reports on the varying rates of progression among Alzheimer's Disease (AD) patients; however, there has been no quantitative study of the amount of heterogeneity in AD. Obtaining a reliable quantitative measure of AD progression rates and their variances among the patients for each stage of AD is essential for evaluating results of any clinical study. The Global Deterioration Scale (GDS) and Functional Assessment Staging procedure (FAST) characterize seven stages in the course of AD from normal aging to severe dementia. Each GDS/FAST stage has a published mean duration, but the variance is unknown. We use statistical analysis to reconstruct GDS/FAST stage durations in a cohort of 648 AD patients with an average follow-up time of 4.78 years. Calculations for GDS/FAST stages 4-6 reveal that the standard deviations for stage durations are comparable with their mean values, indicating the presence of large variations in the AD progression among patients. Such amount of heterogeneity in the course of progression of AD is consistent with the existence of several sub-groups of AD patients, which differ by their patterns of decline.
format	article
author	Natalia L Komarova Craig J Thalhauser
author_facet	Natalia L Komarova Craig J Thalhauser
author_sort	Natalia L Komarova
title	High degree of heterogeneity in Alzheimer's disease progression patterns.
title_short	High degree of heterogeneity in Alzheimer's disease progression patterns.
title_full	High degree of heterogeneity in Alzheimer's disease progression patterns.
title_fullStr	High degree of heterogeneity in Alzheimer's disease progression patterns.
title_full_unstemmed	High degree of heterogeneity in Alzheimer's disease progression patterns.
title_sort	high degree of heterogeneity in alzheimer's disease progression patterns.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/ee8f51759d4c43a1b7b743d170433e8a
work_keys_str_mv	AT natalialkomarova highdegreeofheterogeneityinalzheimersdiseaseprogressionpatterns AT craigjthalhauser highdegreeofheterogeneityinalzheimersdiseaseprogressionpatterns
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High degree of heterogeneity in Alzheimer's disease progression patterns.

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