Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres

Mammalian shelterin proteins POT1 and TPP1 form a stable heterodimer that protects telomere ends. The authors exploit the observation that mice have two POT1 paralogs, enabling functional dissections to shed important light on the mechanistic basis for human POT1 functions.

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Autores principales:	Peili Gu, Shuting Jia, Taylor Takasugi, Valerie M. Tesmer, Jayakrishnan Nandakumar, Yong Chen, Sandy Chang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ee90eb3691bd47059ac051ce7d98f252
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spelling	oai:doaj.org-article:ee90eb3691bd47059ac051ce7d98f2522021-12-02T15:15:41ZDistinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres10.1038/s41467-021-25799-72041-1723https://doaj.org/article/ee90eb3691bd47059ac051ce7d98f2522021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25799-7https://doaj.org/toc/2041-1723Mammalian shelterin proteins POT1 and TPP1 form a stable heterodimer that protects telomere ends. The authors exploit the observation that mice have two POT1 paralogs, enabling functional dissections to shed important light on the mechanistic basis for human POT1 functions.Peili GuShuting JiaTaylor TakasugiValerie M. TesmerJayakrishnan NandakumarYong ChenSandy ChangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Peili Gu Shuting Jia Taylor Takasugi Valerie M. Tesmer Jayakrishnan Nandakumar Yong Chen Sandy Chang Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres
description	Mammalian shelterin proteins POT1 and TPP1 form a stable heterodimer that protects telomere ends. The authors exploit the observation that mice have two POT1 paralogs, enabling functional dissections to shed important light on the mechanistic basis for human POT1 functions.
format	article
author	Peili Gu Shuting Jia Taylor Takasugi Valerie M. Tesmer Jayakrishnan Nandakumar Yong Chen Sandy Chang
author_facet	Peili Gu Shuting Jia Taylor Takasugi Valerie M. Tesmer Jayakrishnan Nandakumar Yong Chen Sandy Chang
author_sort	Peili Gu
title	Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres
title_short	Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres
title_full	Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres
title_fullStr	Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres
title_full_unstemmed	Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres
title_sort	distinct functions of pot1 proteins contribute to the regulation of telomerase recruitment to telomeres
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ee90eb3691bd47059ac051ce7d98f252
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Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres

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