Pellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks

Occurrence of DNA double-strand break (DSB) repair is important for genome integrity. Here, the authors reveal that Pellino1 is a DSB-responsive ubiquitin ligase required for promoting the accumulation of ATM and MRN complex at DSB sites via NBS1 ubiquitination.

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Autores principales:	Geun-Hyoung Ha, Jae-Hoon Ji, Sunyoung Chae, Jihyun Park, Suhyeon Kim, Jin-Kwan Lee, Yonghyeon Kim, Sunwoo Min, Jeong-Min Park, Tae-Hong Kang, Ho Lee, Hyeseong Cho, Chang-Woo Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ee92c7e083594457b9d565bc9efb1942
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spelling	oai:doaj.org-article:ee92c7e083594457b9d565bc9efb19422021-12-02T16:57:22ZPellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks10.1038/s41467-019-09641-92041-1723https://doaj.org/article/ee92c7e083594457b9d565bc9efb19422019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09641-9https://doaj.org/toc/2041-1723Occurrence of DNA double-strand break (DSB) repair is important for genome integrity. Here, the authors reveal that Pellino1 is a DSB-responsive ubiquitin ligase required for promoting the accumulation of ATM and MRN complex at DSB sites via NBS1 ubiquitination.Geun-Hyoung HaJae-Hoon JiSunyoung ChaeJihyun ParkSuhyeon KimJin-Kwan LeeYonghyeon KimSunwoo MinJeong-Min ParkTae-Hong KangHo LeeHyeseong ChoChang-Woo LeeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Geun-Hyoung Ha Jae-Hoon Ji Sunyoung Chae Jihyun Park Suhyeon Kim Jin-Kwan Lee Yonghyeon Kim Sunwoo Min Jeong-Min Park Tae-Hong Kang Ho Lee Hyeseong Cho Chang-Woo Lee Pellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks
description	Occurrence of DNA double-strand break (DSB) repair is important for genome integrity. Here, the authors reveal that Pellino1 is a DSB-responsive ubiquitin ligase required for promoting the accumulation of ATM and MRN complex at DSB sites via NBS1 ubiquitination.
format	article
author	Geun-Hyoung Ha Jae-Hoon Ji Sunyoung Chae Jihyun Park Suhyeon Kim Jin-Kwan Lee Yonghyeon Kim Sunwoo Min Jeong-Min Park Tae-Hong Kang Ho Lee Hyeseong Cho Chang-Woo Lee
author_facet	Geun-Hyoung Ha Jae-Hoon Ji Sunyoung Chae Jihyun Park Suhyeon Kim Jin-Kwan Lee Yonghyeon Kim Sunwoo Min Jeong-Min Park Tae-Hong Kang Ho Lee Hyeseong Cho Chang-Woo Lee
author_sort	Geun-Hyoung Ha
title	Pellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks
title_short	Pellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks
title_full	Pellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks
title_fullStr	Pellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks
title_full_unstemmed	Pellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks
title_sort	pellino1 regulates reversible atm activation via nbs1 ubiquitination at dna double-strand breaks
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ee92c7e083594457b9d565bc9efb1942
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Pellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks

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