Pellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks

Pellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks

Occurrence of DNA double-strand break (DSB) repair is important for genome integrity. Here, the authors reveal that Pellino1 is a DSB-responsive ubiquitin ligase required for promoting the accumulation of ATM and MRN complex at DSB sites via NBS1 ubiquitination.

Guardado en:
Detalles Bibliográficos
Autores principales: Geun-Hyoung Ha, Jae-Hoon Ji, Sunyoung Chae, Jihyun Park, Suhyeon Kim, Jin-Kwan Lee, Yonghyeon Kim, Sunwoo Min, Jeong-Min Park, Tae-Hong Kang, Ho Lee, Hyeseong Cho, Chang-Woo Lee
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/ee92c7e083594457b9d565bc9efb1942
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

Ejemplares similares