Structural and biochemical evidence supporting poly ADP-ribosylation in the bacterium Deinococcus radiodurans

Poly-ADP-ribosylation (PARylation) is a well-known regulatory event in eukaryotes but has not yet been observed in bacteria. Here, the authors solve the structure of a bacterial PAR-glycohydrolase and provide evidence for a prokaryotic PARylation machinery involved in the response to genotoxic stres...

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Autores principales:	Chao-Cheng Cho, Chia-Yu Chien, Yi-Chih Chiu, Meng-Hsuan Lin, Chun-Hua Hsu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ee938e1dfa4b4d808584c20cfe83a6c4
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spelling	oai:doaj.org-article:ee938e1dfa4b4d808584c20cfe83a6c42021-12-02T17:02:16ZStructural and biochemical evidence supporting poly ADP-ribosylation in the bacterium Deinococcus radiodurans10.1038/s41467-019-09153-62041-1723https://doaj.org/article/ee938e1dfa4b4d808584c20cfe83a6c42019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09153-6https://doaj.org/toc/2041-1723Poly-ADP-ribosylation (PARylation) is a well-known regulatory event in eukaryotes but has not yet been observed in bacteria. Here, the authors solve the structure of a bacterial PAR-glycohydrolase and provide evidence for a prokaryotic PARylation machinery involved in the response to genotoxic stress.Chao-Cheng ChoChia-Yu ChienYi-Chih ChiuMeng-Hsuan LinChun-Hua HsuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chao-Cheng Cho Chia-Yu Chien Yi-Chih Chiu Meng-Hsuan Lin Chun-Hua Hsu Structural and biochemical evidence supporting poly ADP-ribosylation in the bacterium Deinococcus radiodurans
description	Poly-ADP-ribosylation (PARylation) is a well-known regulatory event in eukaryotes but has not yet been observed in bacteria. Here, the authors solve the structure of a bacterial PAR-glycohydrolase and provide evidence for a prokaryotic PARylation machinery involved in the response to genotoxic stress.
format	article
author	Chao-Cheng Cho Chia-Yu Chien Yi-Chih Chiu Meng-Hsuan Lin Chun-Hua Hsu
author_facet	Chao-Cheng Cho Chia-Yu Chien Yi-Chih Chiu Meng-Hsuan Lin Chun-Hua Hsu
author_sort	Chao-Cheng Cho
title	Structural and biochemical evidence supporting poly ADP-ribosylation in the bacterium Deinococcus radiodurans
title_short	Structural and biochemical evidence supporting poly ADP-ribosylation in the bacterium Deinococcus radiodurans
title_full	Structural and biochemical evidence supporting poly ADP-ribosylation in the bacterium Deinococcus radiodurans
title_fullStr	Structural and biochemical evidence supporting poly ADP-ribosylation in the bacterium Deinococcus radiodurans
title_full_unstemmed	Structural and biochemical evidence supporting poly ADP-ribosylation in the bacterium Deinococcus radiodurans
title_sort	structural and biochemical evidence supporting poly adp-ribosylation in the bacterium deinococcus radiodurans
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ee938e1dfa4b4d808584c20cfe83a6c4
work_keys_str_mv	AT chaochengcho structuralandbiochemicalevidencesupportingpolyadpribosylationinthebacteriumdeinococcusradiodurans AT chiayuchien structuralandbiochemicalevidencesupportingpolyadpribosylationinthebacteriumdeinococcusradiodurans AT yichihchiu structuralandbiochemicalevidencesupportingpolyadpribosylationinthebacteriumdeinococcusradiodurans AT menghsuanlin structuralandbiochemicalevidencesupportingpolyadpribosylationinthebacteriumdeinococcusradiodurans AT chunhuahsu structuralandbiochemicalevidencesupportingpolyadpribosylationinthebacteriumdeinococcusradiodurans
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Structural and biochemical evidence supporting poly ADP-ribosylation in the bacterium Deinococcus radiodurans

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