Mechanical adaptation of trabecular bone morphology in the mammalian mandible

Abstract Alveolar bone, together with the underlying trabecular bone, fulfils an important role in providing structural support against masticatory forces. Diseases such as osteoporosis or periodontitis cause alveolar bone resorption which weakens this structural support and is a major cause of toot...

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Autores principales:	Peter J. Watson, Laura C. Fitton, Carlo Meloro, Michael J. Fagan, Flora Gröning
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ee93b7ffd5004b2f91d13cfb39f7ae6e
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spelling	oai:doaj.org-article:ee93b7ffd5004b2f91d13cfb39f7ae6e2021-12-02T11:41:03ZMechanical adaptation of trabecular bone morphology in the mammalian mandible10.1038/s41598-018-25597-02045-2322https://doaj.org/article/ee93b7ffd5004b2f91d13cfb39f7ae6e2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25597-0https://doaj.org/toc/2045-2322Abstract Alveolar bone, together with the underlying trabecular bone, fulfils an important role in providing structural support against masticatory forces. Diseases such as osteoporosis or periodontitis cause alveolar bone resorption which weakens this structural support and is a major cause of tooth loss. However, the functional relationship between alveolar bone remodelling within the molar region and masticatory forces is not well understood. This study investigated this relationship by comparing mammalian species with different diets and functional loading (Felis catus, Cercocebus atys, Homo sapiens, Sus scrofa, Oryctolagus cuniculus, Ovis aries). We performed histomorphometric analyses of trabecular bone morphology (bone volume fraction, trabecular thickness and trabecular spacing) and quantified the variation of bone and tooth root volumes along the tooth row. A principal component analysis and non-parametric MANOVA showed statistically significant differences in trabecular bone morphology between species with contrasting functional loading, but these differences were not seen in sub-adult specimens. Our results support a strong, but complex link between masticatory function and trabecular bone morphology. Further understanding of a potential functional relationship could aid the diagnosis and treatment of mandibular diseases causing alveolar bone resorption, and guide the design and evaluation of dental implants.Peter J. WatsonLaura C. FittonCarlo MeloroMichael J. FaganFlora GröningNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Peter J. Watson Laura C. Fitton Carlo Meloro Michael J. Fagan Flora Gröning Mechanical adaptation of trabecular bone morphology in the mammalian mandible
description	Abstract Alveolar bone, together with the underlying trabecular bone, fulfils an important role in providing structural support against masticatory forces. Diseases such as osteoporosis or periodontitis cause alveolar bone resorption which weakens this structural support and is a major cause of tooth loss. However, the functional relationship between alveolar bone remodelling within the molar region and masticatory forces is not well understood. This study investigated this relationship by comparing mammalian species with different diets and functional loading (Felis catus, Cercocebus atys, Homo sapiens, Sus scrofa, Oryctolagus cuniculus, Ovis aries). We performed histomorphometric analyses of trabecular bone morphology (bone volume fraction, trabecular thickness and trabecular spacing) and quantified the variation of bone and tooth root volumes along the tooth row. A principal component analysis and non-parametric MANOVA showed statistically significant differences in trabecular bone morphology between species with contrasting functional loading, but these differences were not seen in sub-adult specimens. Our results support a strong, but complex link between masticatory function and trabecular bone morphology. Further understanding of a potential functional relationship could aid the diagnosis and treatment of mandibular diseases causing alveolar bone resorption, and guide the design and evaluation of dental implants.
format	article
author	Peter J. Watson Laura C. Fitton Carlo Meloro Michael J. Fagan Flora Gröning
author_facet	Peter J. Watson Laura C. Fitton Carlo Meloro Michael J. Fagan Flora Gröning
author_sort	Peter J. Watson
title	Mechanical adaptation of trabecular bone morphology in the mammalian mandible
title_short	Mechanical adaptation of trabecular bone morphology in the mammalian mandible
title_full	Mechanical adaptation of trabecular bone morphology in the mammalian mandible
title_fullStr	Mechanical adaptation of trabecular bone morphology in the mammalian mandible
title_full_unstemmed	Mechanical adaptation of trabecular bone morphology in the mammalian mandible
title_sort	mechanical adaptation of trabecular bone morphology in the mammalian mandible
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ee93b7ffd5004b2f91d13cfb39f7ae6e
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_version_	1718395495021281280

Mechanical adaptation of trabecular bone morphology in the mammalian mandible

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